His homer soared over the visitors' bullpen, landing several rows into the bleachers.
"He backspun it and it went about as far as I've seen a ball go in this stadium, probably nine, 10 rows back," said interim manager Torey Lovullo. "It was a beautiful swing, it was a great finish, and it was a typical David moment."
Ortiz came to bat again with the bases loaded in the second inning and drove a sacrifice fly to the warning track in center field. His right calf tightened up on the play, and he was replaced by pinch-hitter Allen Craig in the fifth.
"We're trying to figure out how he did it, whether it was during the swing or whether it was when he was running the bases," Lovullo said. "We thought it was the best thing to take him off the field and reevaluate him [Monday] morning."
Ortiz was not available for comment after the game. He is considered day to day.
With his latest long drive, Ortiz became the fourth player in Red Sox history to hit 200 homers at Fenway. He joined Ted Williams (248), Carl Yastrzemski (237) and Jim Rice (208) on that list.
The dinger was also Ortiz's 31st of the season. On Saturday, he hit No. 30 to set a franchise record with nine career 30-homer campaigns. Williams had eight. Since the All-Star break, Otiz has gone deep 16 times in 42 games