Rookie Christian Colon made his fourth start at second base in the series opener against the Twins.
"Omar's been playing with it for two weeks, but we feel Colon can fill in for a couple days, let him get back to where it's manageable," Yost said. "Two or three days, we'll look at it and see how he feels."
Infante had both a sore shoulder and a sore elbow during Spring Training this year. Earlier in the season, he was struck in the face by a pitch, but he missed only two games.
Yost also had Jarrod Dyson leading off for the third time in four games instead of Nori Aoki, who was stuck in an 0-for-17 skid.