Cubs Roster & Staff
Transactions
| Date | Transaction |
| 03/31/21 | Chicago Cubs sent 2B Ildemaro Vargas outright to Cubs Alternate Training Site. |
| 03/31/21 | Chicago Cubs designated P James Norwood for assignment. |
| 03/31/21 | Chicago Cubs signed free agent C Tony Wolters. |
| 03/29/21 | Chicago Cubs signed free agent SS Andrew Romine. |
| 03/29/21 | P Ryan Meisinger assigned to Chicago Cubs . |
| 03/29/21 | CF Cameron Maybin assigned to Chicago Cubs . |
| 03/29/21 | CF Cameron Maybin assigned to Chicago Cubs . |
| 03/29/21 | P Ryan Meisinger assigned to Chicago Cubs . |
| 03/28/21 | Chicago Cubs selected the contract of P Rex Brothers. |
| 03/28/21 | Chicago Cubs selected the contract of 2B Eric Sogard. |
| 03/28/21 | Chicago Cubs designated 2B Ildemaro Vargas for assignment. |
| 03/28/21 | Chicago Cubs selected the contract of 2B Eric Sogard from Iowa Cubs. |
| 03/28/21 | Chicago Cubs selected the contract of 3B Matt Duffy from Iowa Cubs. |
| 03/28/21 | Chicago Cubs selected the contract of 2B Eric Sogard. |
| 03/28/21 | Chicago Cubs selected the contract of LHP Rex Brothers. |
| 03/28/21 | Chicago Cubs selected the contract of P Rex Brothers from Iowa Cubs. |
| 03/28/21 | Chicago Cubs released P Jerry Vasto. |
| 03/27/21 | Chicago Cubs optioned SS Nico Hoerner to Iowa Cubs. |
| 03/27/21 | P Ben Holmes assigned to Chicago Cubs . |
| 03/27/21 | Chicago Cubs released CF Cameron Maybin. |
| 03/27/21 | Chicago Cubs optioned P Brad Wieck to Iowa Cubs. |
| 03/27/21 | Chicago Cubs signed free agent C Erick Castillo. |
| 03/27/21 | P Ben Holmes assigned to Chicago Cubs . |
| 03/26/21 | Chicago Cubs optioned P Brad Wieck to Iowa Cubs. |
| 03/23/21 | Chicago Cubs placed P Tyson Miller on the 10 day disabled list. |
| 03/20/21 | P Pedro Strop assigned to Chicago Cubs . |
| 03/20/21 | P Pedro Strop assigned to Chicago Cubs . |
| 03/19/21 | Chicago Cubs optioned P Brailyn Marquez to Tennessee Smokies. |
| 03/19/21 | Chicago Cubs optioned P Justin Steele to Iowa Cubs. |
| 03/19/21 | Chicago Cubs optioned P James Norwood to Iowa Cubs. |
| 03/19/21 | Chicago Cubs optioned P Kyle Ryan to Iowa Cubs. |
| 03/15/21 | Chicago Cubs optioned P Keegan Thompson to Iowa Cubs. |
| 03/12/21 | Chicago Cubs optioned P Kohl Stewart to Iowa Cubs. |
| 03/12/21 | Chicago Cubs optioned P Manuel Rodriguez to Tennessee Smokies. |
| 03/12/21 | Chicago Cubs optioned C Miguel Amaya to Tennessee Smokies. |
| 03/12/21 | P Gray Fenter returned to Baltimore Orioles from Chicago Cubs. |
| 03/12/21 | Chicago Cubs optioned P Tyson Miller to Iowa Cubs. |
| 03/12/21 | Chicago Cubs optioned P Cory Abbott to Iowa Cubs. |
| 03/12/21 | Chicago Cubs optioned SS Christopher Morel to Tennessee Smokies. |
| 03/07/21 | Pittsburgh Pirates traded 1B Shendrik Apostel to Chicago Cubs for P Duane Underwood Jr.. |
| 03/07/21 | P Robert Stock assigned to Chicago Cubs . |
| 03/07/21 | Pittsburgh Pirates traded 1B Shendrik Apostel to Chicago Cubs for P Duane Underwood Jr.. |
| 03/07/21 | P Robert Stock assigned to Chicago Cubs . |
| 03/05/21 | Chicago Cubs signed free agent 2B Eric Sogard. |
| 03/05/21 | Chicago Cubs signed free agent 2B Eric Sogard. |
| 03/02/21 | Chicago Cubs signed free agent P Ryan Tepera. |
| 03/02/21 | Chicago Cubs signed free agent RHP Ryan Tepera. |
| 03/02/21 | Chicago Cubs sent P Robert Stock outright to Iowa Cubs. |
| 03/02/21 | Chicago Cubs designated P Duane Underwood Jr. for assignment. |
| 03/01/21 | CF Cameron Maybin assigned to Chicago Cubs . |
| 03/01/21 | C Tyler Payne assigned to Chicago Cubs . |
| 03/01/21 | 2B Andy Weber assigned to Chicago Cubs . |
| 03/01/21 | C Tyler Payne assigned to Chicago Cubs . |
| 03/01/21 | OF Brennen Davis assigned to Chicago Cubs . |
| 03/01/21 | 2B Chase Strumpf assigned to Chicago Cubs . |
| 03/01/21 | 2B Andy Weber assigned to Chicago Cubs . |
| 03/01/21 | Chicago Cubs signed free agent P Ryan Meisinger. |
| 03/01/21 | 2B Chase Strumpf assigned to Chicago Cubs . |
| 03/01/21 | OF Brennen Davis assigned to Chicago Cubs . |