Cubs Roster & Staff
Transactions
| Date | Transaction |
| 09/30/25 | 1B Carlos Santana roster status changed by Chicago Cubs. |
| 09/30/25 | RF Owen Caissie roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Cade Horton roster status changed by Chicago Cubs. |
| 09/30/25 | C Miguel Amaya roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Porter Hodge roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Javier Assad roster status changed by Chicago Cubs. |
| 09/30/25 | LHP Luke Little roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Jack Neely roster status changed by Chicago Cubs. |
| 09/30/25 | LHP Jordan Wicks roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Eli Morgan roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Gavin Hollowell roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Ryan Brasier roster status changed by Chicago Cubs. |
| 09/30/25 | RHP Ethan Roberts roster status changed by Chicago Cubs. |
| 09/29/25 | Chicago Cubs activated C Miguel Amaya from the 10-day injured list. |
| 09/29/25 | Chicago Cubs activated RHP Cade Horton from the 15-day injured list. |
| 09/29/25 | Chicago Cubs activated RF Owen Caissie from the 7-day injured list. |
| 09/29/25 | Chicago Cubs activated RHP Ryan Brasier from the 15-day injured list. |
| 09/29/25 | Chicago Cubs recalled LHP Luke Little from Iowa Cubs. |
| 09/29/25 | Chicago Cubs recalled RHP Porter Hodge from Iowa Cubs. |
| 09/29/25 | Chicago Cubs recalled RHP Jack Neely from Iowa Cubs. |
| 09/29/25 | Chicago Cubs recalled RHP Ethan Roberts from Iowa Cubs. |
| 09/29/25 | Chicago Cubs recalled RHP Eli Morgan from Iowa Cubs. |
| 09/29/25 | Chicago Cubs recalled 1B Carlos Santana from ACL Cubs. |
| 09/29/25 | Chicago Cubs recalled RHP Gavin Hollowell from Iowa Cubs. |
| 09/27/25 | Chicago Cubs placed RHP Cade Horton on the 15-day injured list retroactive to September 25, 2025. Right rib fracture. |
| 09/27/25 | Chicago Cubs recalled LHP Jordan Wicks from ACL Cubs. |
| 09/26/25 | Chicago Cubs activated RF Kyle Tucker from the 10-day injured list. |
| 09/26/25 | Chicago Cubs optioned 1B Carlos Santana to ACL Cubs. |
| 09/24/25 | Chicago Cubs activated RHP Daniel Palencia from the 15-day injured list. |
| 09/24/25 | Chicago Cubs optioned LHP Jordan Wicks to ACL Cubs. |
| 09/21/25 | Chicago Cubs released RHP Nate Pearson. |
| 09/20/25 | Chicago Cubs designated RHP Nate Pearson for assignment. |
| 09/20/25 | Chicago Cubs sent RHP Daniel Palencia on a rehab assignment to Iowa Cubs. |
| 09/20/25 | Chicago Cubs activated RHP Eli Morgan from the 60-day injured list. |
| 09/20/25 | Chicago Cubs recalled LHP Jordan Wicks from Iowa Cubs. |
| 09/20/25 | Chicago Cubs optioned RHP Porter Hodge to Iowa Cubs. |
| 09/20/25 | Chicago Cubs optioned RHP Eli Morgan to Iowa Cubs. |
| 09/16/25 | Chicago Cubs sent C Miguel Amaya on a rehab assignment to Iowa Cubs. |
| 09/16/25 | 1B Justin Turner changed number to 3. |
| 09/16/25 | LF Willi Castro changed number to 1. |
| 09/15/25 | 1B Justin Turner changed number to 21. |
| 09/15/25 | Chicago Cubs activated RHP Michael Soroka from the 15-day injured list. |
| 09/15/25 | LF Willi Castro changed number to 21. |
| 09/15/25 | Chicago Cubs optioned RHP Ben Brown to Iowa Cubs. |
| 09/14/25 | Chicago Cubs recalled RF Kevin Alcántara from Iowa Cubs. |
| 09/13/25 | 1B Anthony Rizzo retired. |
| 09/13/25 | Chicago Cubs placed RF Owen Caissie on the 7-day injured list. Convussion. |
| 09/13/25 | Chicago Cubs optioned RF Kevin Alcántara to Iowa Cubs. |
| 09/13/25 | Chicago Cubs recalled RF Owen Caissie from Iowa Cubs. |
| 09/11/25 | Chicago Cubs sent RHP Michael Soroka on a rehab assignment to Iowa Cubs. |
| 09/10/25 | Chicago Cubs activated RHP Jameson Taillon from the 15-day injured list. |
| 09/10/25 | Chicago Cubs optioned RHP Ethan Roberts to Iowa Cubs. |
| 09/09/25 | Chicago Cubs placed RF Kyle Tucker on the 10-day injured list retroactive to September 6, 2025. Left calf strain. |
| 09/09/25 | Chicago Cubs recalled C Moisés Ballesteros from Iowa Cubs. |
| 09/08/25 | Chicago Cubs placed RHP Daniel Palencia on the 15-day injured list. Right shoulder strain. |
| 09/08/25 | Chicago Cubs recalled RHP Ethan Roberts from Iowa Cubs. |
| 09/05/25 | Chicago Cubs sent RHP Ryan Brasier on a rehab assignment to Iowa Cubs. |
| 09/05/25 | Chicago Cubs sent RHP Ryan Brasier on a rehab assignment to Iowa Cubs. |
| 09/04/25 | Chicago Cubs sent RHP Jameson Taillon on a rehab assignment to Iowa Cubs. |
| 09/03/25 | Chicago White Sox claimed 3B Ben Cowles off waivers from Chicago Cubs. |
| 09/03/25 | Chicago Cubs sent LHP Tom Cosgrove outright to Iowa Cubs. |
| 09/01/25 | RHP Michael Soroka changed number to 99. |
| 09/01/25 | Chicago Cubs signed free agent RHP Joe Ross to a minor league contract. |
| 09/01/25 | Chicago Cubs designated 3B Ben Cowles for assignment. |
| 09/01/25 | Chicago Cubs activated RHP Aaron Civale. |
| 09/01/25 | Chicago Cubs signed free agent 1B Carlos Santana. |
| 09/01/25 | Chicago Cubs recalled RF Kevin Alcántara from Iowa Cubs. |
| 09/01/25 | Chicago Cubs optioned RF Owen Caissie to Iowa Cubs. |