Wright threw a pitch to Victor Martinez, who singled, and pitching coach Dave Wallace and manager Buck Showalter came out immediately with head athletic trainer Richie Bancells. Wright walked off the mound after several minutes and was replaced by Mychal Givens.
"Initially, we thought it was a cramp. He said it felt a lot better after two-thirds of an inning when he came in," Showalter said. "And then he went back out and I noticed he looked a little gingerly going back out there between innings."
Wright said he had a cramp in his calf during his last outing for Triple-A Norfolk but felt fine afterward.
"The next couple of days I felt fine," Wright said. "I threw a bullpen yesterday and felt perfectly fine, and then today, the throw down from [Matt] Wieters, I felt it grab pretty good."
Both Givens and Wright -- ranked among the Orioles' top prospects -- were added to the roster on Friday in the wake of the O's trading of Tommy Hunter and designating Bud Norris.