Manuel is in his sixth season in the Cubs organization following three seasons in the Mexican League (2014-16)... Made his major league debut July 30, 2021 in Washington, tossing 1.0 perfect inning with two strikeouts... Appeared in the 2021 SiriusXM All-Star Futures Game, pitching 1.0 scoreless inning for the N.L... Was selected to the Cubs' 40-man roster Nov. 20, 2019... Is 6-9 with a 4.45 ERA (68 ER/137.2 IP) over 103 career minor league games, all in relief... Has struck out 194 batters over 137.2 career minor league innings, good for a 12.7 SO/9 IP rate... Earned Northwest League Pitcher of the Week honors July 9, 2017, after tossing 6.0 hitless and scoreless innings with nine strikeouts over two relief outings during the week... Was signed by the Cubs as a non-drafted free agent, July 21, 2016... In three seasons with Leones de Yucatán in the Mexican League from 2014-16, went 5-1 with a 2.93 ERA (22 ER/67.2 IP) in 72 relief outings... Was named a mid-season All-Star and Rookie of the Year in 2015.
In 2021, Manuel made his major league debut, appearing in 20 games out of the bullpen for Chicago, going 3-3 with a 6.11 ERA (12 ER/17.2 IP)... Pitched for the N.L. in the SiriusXM All-Star Futures Game, tossing 1.0 scoreless inning... Was recalled from Triple-A Iowa on July 30 ... made his major league debut the same night in Washington (1.0 IP, 0 H, 0 R/ ER, 0 BB, 2 SO)... Earned his first career save Aug. 4 at Colorado... Recorded his first career win Aug. 18 in Cincinnati (0 ER/2.0 IP)... Pitched to a 0.75 ERA (1 ER/12.0 IP) over 11 appearances from Aug. 10-Sept. 5, including 7.0 consecutive scoreless innings from Aug. 10-23... Was placed on the injured list Sept. 17 and missed the rest of the season with right shoulder inflammation... Went 1-1 with a 1.31 ERA (3 ER/20.2 IP) and five saves over 20 outings between Double-A Tennessee and Iowa.
Manuel suffered a right bicep strain during a Spring Training game, March 1, and missed the season...was recalled from Double-A Tennessee and placed on the 45-day injured list, September 25.
Manuel went 1-3 with two saves and a 3.45 ERA (18 ER/47.0 IP) in 35 relief appearances with Single-A Myrtle Beach...struck out 65 batters and walked only 17 in 47.0 innings, an average of 12.4 strikeouts and 3.2 walks per 9.0 innings, while limiting foes to a .242 batting average...Posted a 1.96 ERA (5 ER/23.0 IP) in 17 outings after the All-Star Break, holding opponents to a .212 average while posting a 1.04 WHIP in that span...On injured list, June 14-27, with a right shoulder inpingement.
Manuel appeared in 32 games with Single-A South Bend, going 3-5 with three saves and a 7.59 ERA (34 ER/40.1 IP)...Struck out 64 batters in 40.1 innings, including a season-high tying four strikeouts in four games...On disabled list, May 30-July 3, with right biceps tendinitis.
In his first season in the Cubs organization, he went a combined 1-0 with two saves and a 3.94 ERA (13 ER/29.2 IP) between Single-A Eugene and Single-A South Bend...Was named Northwest League Pitcher of the Week, July 3-9...struck out nine batters in 6.0-hitless and scoreless innings over two relief outings.