Cubs Roster & Staff
Transactions
| Date | Transaction |
| 03/31/12 | Chicago Cubs released 2B Bobby Scales. |
| 03/31/12 | OF Michael Burgess assigned to Chicago Cubs. |
| 03/29/12 | Chicago Cubs optioned Casey Coleman to Iowa Cubs. |
| 03/29/12 | LHP Casey Harman assigned to Chicago Cubs. |
| 03/29/12 | 1B Justin Bour assigned to Chicago Cubs. |
| 03/29/12 | Chicago Cubs optioned Randy Wells to Iowa Cubs. |
| 03/29/12 | Chicago Cubs optioned LHP Travis Wood to Iowa Cubs. |
| 03/29/12 | Chicago Cubs optioned Welington Castillo to Iowa Cubs. |
| 03/29/12 | Chicago Cubs optioned Scott Maine to Iowa Cubs. |
| 03/29/12 | Chicago Cubs optioned Dave Sappelt to Iowa Cubs. |
| 03/27/12 | OF John Andreoli assigned to Chicago Cubs. |
| 03/27/12 | Chicago Cubs released C Jason Jaramillo. |
| 03/27/12 | SS Arismendy Alcantara assigned to Chicago Cubs. |
| 03/27/12 | 2B Wes Darvill assigned to Chicago Cubs. |
| 03/26/12 | C Wilfredo Petit assigned to Chicago Cubs. |
| 03/26/12 | RF Nelson Perez assigned to Chicago Cubs. |
| 03/26/12 | IF Zeke DeVoss assigned to Chicago Cubs. |
| 03/26/12 | OF Trey Martin assigned to Chicago Cubs. |
| 03/26/12 | OF Eduardo Gonzalez assigned to Chicago Cubs. |
| 03/26/12 | SS Marco Hernandez assigned to Chicago Cubs. |
| 03/26/12 | Chicago Cubs signed free agent RHP Shawn Camp to a minor league contract and invited him to spring training. |
| 03/26/12 | Chicago Cubs released LHP Trever Miller. |
| 03/25/12 | 2B Ronald Torreyes assigned to Chicago Cubs. |
| 03/24/12 | Alberto Cabrera assigned to Chicago Cubs. |
| 03/24/12 | C Rafael Lopez assigned to Chicago Cubs. |
| 03/24/12 | Marco Antonio Carrillo assigned to Chicago Cubs. |
| 03/24/12 | RHP Andy Sonnanstine elected free agency. |
| 03/23/12 | LHP Jeffry Antigua assigned to Chicago Cubs. |
| 03/23/12 | Chicago Cubs optioned Adrian Cardenas to Iowa Cubs. |
| 03/23/12 | Chicago Cubs optioned Anthony Rizzo to Iowa Cubs. |
| 03/22/12 | Chicago Cubs sent Andy Sonnanstine outright to Iowa Cubs. |
| 03/20/12 | C Sergio Burruel assigned to Chicago Cubs. |
| 03/20/12 | OF Taiwan Easterling assigned to Chicago Cubs. |
| 03/20/12 | OF Abner Abreu assigned to Chicago Cubs. |
| 03/20/12 | 3B Marquez Smith assigned to Chicago Cubs. |
| 03/20/12 | C Chad Noble assigned to Chicago Cubs. |
| 03/20/12 | RHP Matt Loosen assigned to Chicago Cubs. |
| 03/20/12 | LHP Austin Kirk assigned to Chicago Cubs. |
| 03/20/12 | RHP Brett Wallach assigned to Chicago Cubs. |
| 03/20/12 | 1B Greg Rohan assigned to Chicago Cubs. |
| 03/19/12 | OF Elieser Bonne assigned to Chicago Cubs. |
| 03/18/12 | 2B Logan Watkins assigned to Chicago Cubs. |
| 03/17/12 | OF Rubi Silva assigned to Chicago Cubs. |
| 03/17/12 | RHP Casey Weathers assigned to Chicago Cubs. |
| 03/17/12 | OF Oliver Zapata assigned to Chicago Cubs. |
| 03/17/12 | RHP Frank Batista assigned to Chicago Cubs. |
| 03/16/12 | Chicago Cubs claimed Frankie De La Cruz off waivers from Milwaukee Brewers. |
| 03/15/12 | Chicago Cubs optioned SS Junior Lake to Tennessee Smokies. |
| 03/15/12 | Chicago Cubs optioned Matt Szczur to Tennessee Smokies. |
| 03/15/12 | Chicago Cubs optioned Josh Vitters to Iowa Cubs. |
| 03/15/12 | Chicago Cubs optioned Alberto Cabrera to Iowa Cubs. |
| 03/15/12 | Chicago Cubs optioned LHP Jeff Beliveau to Iowa Cubs. |
| 03/15/12 | Chicago Cubs optioned LHP John Gaub to Iowa Cubs. |
| 03/15/12 | LF Ty Wright assigned to Chicago Cubs. |
| 03/15/12 | SS Elliot Soto assigned to Chicago Cubs. |
| 03/15/12 | RHP Juan Serrano assigned to Chicago Cubs. |
| 03/15/12 | IF Pin-Chieh Chen assigned to Chicago Cubs. |
| 03/15/12 | OF Reggie Golden assigned to Chicago Cubs. |
| 03/15/12 | 3B Matt Cerda assigned to Chicago Cubs. |
| 03/15/12 | 3B Nate Samson assigned to Chicago Cubs. |
| 03/15/12 | RHP Daniel Berlind assigned to Chicago Cubs. |
| 03/15/12 | RHP Marcus Hatley assigned to Chicago Cubs. |
| 03/15/12 | RHP Oswaldo Martinez assigned to Chicago Cubs. |
| 03/11/12 | Chicago Cubs signed free agent Gerardo Concepcion. |
| 03/11/12 | Chicago Cubs sent Casey Weathers outright to Iowa Cubs. |
| 03/11/12 | LHP Andrew McKirahan assigned to Chicago Cubs. |
| 03/11/12 | RHP Ryan Searle assigned to Chicago Cubs. |
| 03/05/12 | RHP Kevin Rhoderick assigned to Chicago Cubs. |
| 03/05/12 | RHP Tony Zych assigned to Chicago Cubs. |
| 03/04/12 | Chicago Cubs signed free agent C Nathan Maldonado to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent C Carlos Ramirez to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent RHP Jonathan Bautista to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent SS Bryant Flete to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent RHP Jeffry Hernandez to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent RHP Hendry Mercado to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent SS Dalfis Ortiz to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent OF Shamil Ubiera to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent OF Jose Paniagua to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent RHP Jesus Pereyra to a minor league contract. |
| 03/02/12 | Chicago Cubs signed free agent 3B Miguel Rico to a minor league contract. |
| 03/01/12 | Chicago Cubs signed free agent RHP Carlos Llano to a minor league contract. |
| 03/01/12 | Chicago Cubs signed free agent RHP Greyfer Eregua to a minor league contract. |