Cubs Roster & Staff
Transactions
| Date | Transaction |
| 03/29/25 | Chicago Cubs traded RHP Cody Poteet to Baltimore Orioles for cash. |
| 03/27/25 | Chicago Cubs designated RHP Cody Poteet for assignment. |
| 03/27/25 | Chicago Cubs selected the contract of RHP Brad Keller from Iowa Cubs. |
| 03/26/25 | Chicago Cubs placed SS Vidal Bruján on the 10-day injured list retroactive to March 23, 2025. Right elbow sprain. |
| 03/26/25 | Chicago Cubs placed RHP Ryan Brasier on the 15-day injured list retroactive to March 25, 2025. Left groin strain. |
| 03/25/25 | RF Rafael Morel assigned to Chicago Cubs. |
| 03/25/25 | C Carter Trice assigned to Chicago Cubs. |
| 03/25/25 | SS Pedro Ramirez assigned to Chicago Cubs. |
| 03/25/25 | Chicago Cubs placed RHP Tyson Miller on the 15-day injured list retroactive to March 21, 2025. Left hip impingement. |
| 03/25/25 | Chicago Cubs sent RHP Keegan Thompson outright to Iowa Cubs. |
| 03/24/25 | RHP Ben Johnson assigned to Chicago Cubs. |
| 03/24/25 | 1B William Simoneit assigned to Chicago Cubs. |
| 03/24/25 | RHP Ben Johnson roster status changed by Chicago Cubs. |
| 03/23/25 | RHP Joe Nahas assigned to Chicago Cubs. |
| 03/23/25 | LHP Chase Watkins assigned to Chicago Cubs. |
| 03/21/25 | Chicago Cubs optioned LHP Jordan Wicks to Iowa Cubs. |
| 03/17/25 | Chicago Cubs designated RHP Keegan Thompson for assignment. |
| 03/17/25 | Chicago Cubs placed RHP Javier Assad on the 15-day injured list. Left oblique strain. |
| 03/17/25 | Chicago Cubs selected the contract of 2B Matt Shaw from Iowa Cubs. |
| 03/17/25 | Chicago Cubs optioned RHP Daniel Palencia to Iowa Cubs. |
| 03/12/25 | Chicago Cubs released CF Travis Jankowski. |
| 03/12/25 | Chicago Cubs optioned RF Kevin Alcántara to Iowa Cubs. |
| 03/11/25 | RHP Carlo Reyes assigned to Chicago Cubs. |
| 03/11/25 | RHP Yenrri Rojas assigned to Chicago Cubs. |
| 03/11/25 | C Caleb Knight assigned to Chicago Cubs. |
| 03/10/25 | RF Darius Hill assigned to Chicago Cubs. |
| 03/09/25 | Chicago Cubs optioned 3B Ben Cowles to Iowa Cubs. |
| 03/07/25 | Chicago Cubs optioned LHP Luke Little to Iowa Cubs. |
| 03/07/25 | Chicago Cubs optioned RHP Ethan Roberts to Iowa Cubs. |
| 03/06/25 | RHP Sam Thoresen assigned to Chicago Cubs. |
| 03/05/25 | Chicago Cubs signed free agent RHP Jackson Kirkpatrick to a minor league contract. |
| 03/05/25 | Chicago Cubs signed free agent RHP Ethan Bell to a minor league contract. |
| 03/04/25 | Chicago Cubs signed free agent RHP Yency Almonte to a minor league contract. |
| 03/03/25 | Chicago Cubs released LHP Jeff Belge. |
| 03/01/25 | SS Ed Howard assigned to Chicago Cubs. |
| 03/01/25 | SS Yahil Melendez assigned to Chicago Cubs. |
| 03/01/25 | LF Joan Delgado assigned to Chicago Cubs. |
| 03/01/25 | LHP Jeff Belge assigned to Chicago Cubs. |
| 03/01/25 | SS Ty Southisene assigned to Chicago Cubs. |
| 03/01/25 | OF Felix Stevens assigned to Chicago Cubs. |
| 03/01/25 | LF Andy Garriola assigned to Chicago Cubs. |
| 03/01/25 | Chicago Cubs optioned RHP Caleb Kilian to Iowa Cubs. |
| 03/01/25 | Chicago Cubs optioned RHP Cody Poteet to Iowa Cubs. |
| 03/01/25 | Chicago Cubs optioned RHP Jack Neely to Iowa Cubs. |
| 03/01/25 | Chicago Cubs optioned RHP Gavin Hollowell to Iowa Cubs. |