Chris Heisey replaced Bruce in right field and batted in the cleanup spot.
The move was announced about two hours prior to Cincinnati's home game against Milwaukee, a contest the Reds won in extra innings, 4-3. Bruce was able to pinch-hit in the seventh, swinging and missing at three pitches from Milwaukee reliever Will Smith.
Bruce is batting .216 with three home runs and 14 RBIs in 102 at-bats and was 1-for-4 in Saturday's 6-2 Reds win over the Brewers. His next RBI will be the 500th of his career.