Pedroia, who is out with a right hamstring strain, is eligible to return from the disabled list on Friday.
"Yesterday was a good day for him where the intensity to his running started to increase more. We'll get a clearer view on this as we get through to the Miami series," said manager John Farrell. "What we're going to come down to is what's the risk/reward for activating him for the final series this week, on this homestand, or do we take advantage of those four days? The next four days will give us more clarity to that."