Left-hander Jose Quintana allowed three solo home runs as the White Sox dropped their seventh consecutive game with a 3-1 loss to the Orioles.
The White Sox are just 24-49 on the road (.3287), the second lowest winning percentage in the Major Leagues behind Miami (23-47, .3285) . Also, 107 of Chicago's 139 games (77 percent) have been decided by three runs or fewer.
"It's frustrating," White Sox manager Robin Ventura said. "You just keep going. There is nothing else you can do."
Despite the long balls, Quintana allowed just three runs on seven hits with four strikeouts and one walk over seven innings. He lost for the second time in less than a week after allowing just one run in one inning in a rain-shortened start Monday against the Yankees.
"[I] was trying to stop our losing streak today," Quintana said through a translator. "It didn't happen. It was a tough game. Home runs can come and go. Today, there were three of them. It happens."
Left fielder Dayan Viciedo had two of the White Sox five hits.
Orioles right-hander Miguel Gonzalez got his first win since July 20, allowing just one run on four hits with six strikeouts and one walk over seven innings.
Adam Jones picked up his 30th home run and 100th RBI for Baltimore, while Brian Roberts got his fourth homer. J.J. Hardy also went deep for the Orioles and became just the fourth active player to have three or more seasons of 25 homers as a shortstop.
The White Sox have lost 15 of their past 24 games at Camden Yards.
"It's definitely a good way to start the homestand," Hardy said. "You say it's not a must win, but I think it's kind of that point. Our backs are kind of against the wall, and we need to win. We need to get on a streak, and this is a good start."
Jones provided a 1-0 lead for the Orioles, who are in the mix for an American League Wild Card, in the first with a towering homer to left field. The White Sox tied the game in the third when Alejandro De Aza hit into a double play with the bases loaded that allowed Conor Gillaspie to score from third.
"That was our spot," Ventura said. "Gonzalez pitched well. He really pitched from behind well. We got him in that situation and he gets a double play to really get out of it."
Hardy broke the deadlock with a homer to lead off the fifth, and Roberts provided a two-run cushion with another shot three batters later off Quintana.
"He gave up three solo home runs and he pitched well otherwise," said White Sox first baseman Paul Konerko, who was 0-for-4. "Another tough loss for him. He's pitched real well for us this year and we haven't got wins for him."