Pujols was noticeably in a lot of pain after getting plunked in the top of the fourth, but he stayed in the game, ran the bases and played the next half-inning on defense. In the top of the fifth, though, Marc Krauss pinch-hit for him -- then drove a two-run double two innings later, leading the Angels to a 4-3 win.
Pujols left Rogers Centre early to undergo further examination.
"It didn't sound good," Angels center fielder Mike Trout said after the win. "I was on first base and at first I thought it hit the knob. But after the replay, I heard everybody saying it hit the wrist. I just hope everything's all right. He's a big guy in our lineup."
Pujols entered Wednesday's game batting .232 with seven homers and 15 RBIs, but was nonetheless a crucial piece to an offense that had been limited to three runs or less in 22 of the previous 39 games.
The 35-year-old first baseman fractured his left wrist while with the Cardinals in June 2011, banging it against a runner while trying to field a one-hop throw up the first-base line. The injury forced him to miss two weeks, far less than what was initially expected.
"I don't know if there's anything residual from when he fractured it in St. Louis," said Angels manager Mike Scioscia, who wasn't aware of the severity of Pujols' latest injury immediately after the game.