"I hoped [with] the off-day [Monday] it would kind of go away," Myers said. "But I felt it today in the cage and during BP. I took BP and felt that was kind of it."
Myers said the wrist pains him most on the follow-through of his swing.
San Diego manager Bud Black said Myers initially hurt the wrist sliding into a base and when he placed his left hand on the ground during the slide.
Myers, who is hitting .291 with five home runs and 19 RBIs, has had issues with his wrists in the past, but this isn't the right wrist he broke in an outfield collision last May while with the Rays.
Myers did jam his left wrist four games into the season in 2014, but that eventually healed.
Myers entered the game with the most hits (34) and runs (28) on the team. He would have started his fourth consecutive game at first base on Tuesday, after moving from center field after Yonder Alonso landed on the disabled list over the weekend.