Entering Monday night's game, Gomes had been immaculate since being selected from Triple-A Durham when veteran Grant Balfour was designated for assignment.
Gomes had made four scoreless appearances, allowing two hits and a walk while striking out six in 5 2/3 innings. Included in his run was a strikeout of Hanley Ramirez on Thursday at a critical juncture against the Red Sox to help the Rays escape a jam.
Gomes said he "battled" with his fastball throughout his one-inning stint.
"Poor command with my fastball," Gomes said. "That's why I walked Gardner and that's the reason I gave up the home run to McCann. ... My other stuff was actually pretty good. But everybody pitches off their fastball, and if they're not commanding that, you can run into some problems."
Gomes took the loss while seeing his ERA rise to 2.70.
"I'll just go back out there the next time I have that opportunity and get right back at it," Gomes said. "This is the first time all year, between Spring Training, Triple-A and here, where I felt like I actually didn't throw the ball well. ... Next time, if I'm feeling like my fastball command is not great, I'm just going to make a quicker adjustment."