Pirates Roster & Staff
Pirates
| Date | Transaction |
| 09/19/21 | Pittsburgh Pirates recalled RHP Max Kranick from Indianapolis Indians. |
| 09/19/21 | Pittsburgh Pirates placed RHP Bryse Wilson on the 10-day injured list. Left hamstring strain. |
| 09/16/21 | Pittsburgh Pirates sent 2B Michael Chavis on a rehab assignment to Indianapolis Indians. |
| 09/14/21 | Pittsburgh Pirates recalled RHP Enyel De Los Santos from Indianapolis Indians. |
| 09/14/21 | Pittsburgh Pirates placed RHP David Bednar on the 10-day injured list. Right oblique strain. |
| 09/13/21 | Pittsburgh Pirates claimed RHP Enyel De Los Santos off waivers. |
| 09/13/21 | Pittsburgh Pirates claimed RHP Enyel De Los Santos off waivers. |
| 09/13/21 | Pittsburgh Pirates placed LHP Steven Brault on the 60-day injured list. Recurring left lat strain. |
| 09/13/21 | Pittsburgh Pirates placed LHP Steven Brault on the 60-day injured list. Recurring left lat strain. |
| 09/13/21 | Pittsburgh Pirates claimed RHP Enyel De Los Santos off waivers from Philadelphia Phillies. |
| 09/13/21 | Pittsburgh Pirates placed LHP Steven Brault on the 60-day injured list. Recurring left lat strain. |
| 09/11/21 | Pittsburgh Pirates recalled RHP Connor Overton. |
| 09/11/21 | Pittsburgh Pirates recalled RHP Connor Overton. |
| 09/11/21 | Pittsburgh Pirates recalled RHP Connor Overton from Indianapolis Indians. |
| 09/11/21 | Pittsburgh Pirates placed LHP Steven Brault on the 10-day injured list. Recurring left lat strain. |
| 09/07/21 | Pittsburgh Pirates optioned RHP Shea Spitzbarth to Indianapolis Indians. |
| 09/07/21 | Pittsburgh Pirates activated LHP Dillon Peters from the 10-day injured list. |
| 09/07/21 | Pittsburgh Pirates recalled RHP Shea Spitzbarth. |
| 09/07/21 | Pittsburgh Pirates recalled RHP Shea Spitzbarth. |
| 09/07/21 | Pittsburgh Pirates activated LHP Dillon Peters from the 10-day injured list. |
| 09/07/21 | Pittsburgh Pirates activated LHP Dillon Peters from the 10-day injured list. |
| 09/06/21 | Pittsburgh Pirates placed RHP Duane Underwood Jr. on the 60-day injured list. Right shoulder inflammation. |
| 09/06/21 | Pittsburgh Pirates recalled 3B Phillip Evans. |
| 09/06/21 | Pittsburgh Pirates recalled RHP Cody Ponce. |
| 09/06/21 | Pittsburgh Pirates placed RHP Duane Underwood Jr. on the 60-day injured list. Right shoulder inflammation. |
| 09/06/21 | Pittsburgh Pirates placed RHP Duane Underwood Jr. on the 60-day injured list. Right shoulder inflammation. |
| 09/06/21 | Pittsburgh Pirates claimed RHP Connor Overton off waivers from Toronto Blue Jays. |
| 09/06/21 | Pittsburgh Pirates recalled RHP Cody Ponce from Indianapolis Indians. |
| 09/06/21 | Pittsburgh Pirates recalled RHP Cody Ponce. |
| 09/06/21 | Pittsburgh Pirates recalled 3B Phillip Evans. |
| 09/06/21 | Pittsburgh Pirates optioned 3B Phillip Evans to Indianapolis Indians. |
| 09/06/21 | Pittsburgh Pirates optioned RHP Connor Overton to Indianapolis Indians. |
| 09/05/21 | Pittsburgh Pirates recalled RHP Kyle Keller. |
| 09/05/21 | Pittsburgh Pirates recalled RHP Kyle Keller from Indianapolis Indians. |
| 09/05/21 | Pittsburgh Pirates placed RHP JT Brubaker on the 10-day injured list. Right shoulder inflammation. |
| 09/05/21 | Pittsburgh Pirates recalled RHP Shea Spitzbarth from Indianapolis Indians. |
| 09/05/21 | Pittsburgh Pirates recalled RHP Kyle Keller. |
| 09/05/21 | Pittsburgh Pirates placed RHP Duane Underwood Jr. on the 10-day injured list. Right shoulder inflammation. |
| 09/05/21 | Pittsburgh Pirates placed RHP JT Brubaker on the 10-day injured list. Right shoulder inflammation. |
| 09/05/21 | Pittsburgh Pirates placed RHP JT Brubaker on the 10-day injured list. Right shoulder inflammation. |
| 09/04/21 | Pittsburgh Pirates activated RHP JT Brubaker from the 10-day injured list. |
| 09/04/21 | Pittsburgh Pirates optioned RHP Kyle Keller to Indianapolis Indians. |
| 09/02/21 | Pittsburgh Pirates optioned RHP Max Kranick to Indianapolis Indians. |
| 09/02/21 | Pittsburgh Pirates recalled RHP Max Kranick. |
| 09/02/21 | Pittsburgh Pirates recalled RHP Max Kranick. |
| 09/02/21 | Pittsburgh Pirates recalled 3B Phillip Evans from Indianapolis Indians. |
| 09/01/21 | Pittsburgh Pirates selected the contract of RHP Shelby Miller. |
| 09/01/21 | Pittsburgh Pirates selected the contract of RHP Shelby Miller. |
| 09/01/21 | Pittsburgh Pirates recalled RHP Max Kranick from Indianapolis Indians. |
| 09/01/21 | Pittsburgh Pirates selected the contract of RHP Shelby Miller from Indianapolis Indians. |
