Pirates Roster & Staff
Transactions
| Date | Transaction |
| 11/30/21 | LHP Steven Brault elected free agency. |
| 11/30/21 | RHP Chad Kuhl elected free agency. |
| 11/30/21 | 3B Colin Moran elected free agency. |
| 11/29/21 | Pittsburgh Pirates activated RHP Zach Thompson. |
| 11/29/21 | Pittsburgh Pirates activated RHP Zach Thompson. |
| 11/29/21 | Pittsburgh Pirates activated LHP Jose Quintana. |
| 11/29/21 | Pittsburgh Pirates activated LHP Jose Quintana. |
| 11/29/21 | Pittsburgh Pirates signed free agent LF Yoshi Tsutsugo. |
| 11/29/21 | Pittsburgh Pirates designated 3B Colin Moran for assignment. |
| 11/29/21 | Pittsburgh Pirates released RHP Cody Ponce. |
| 11/29/21 | Pittsburgh Pirates signed free agent LHP Jose Quintana. |
| 11/29/21 | Pittsburgh Pirates designated LHP Steven Brault for assignment. |
| 11/29/21 | Pittsburgh Pirates traded C Jacob Stallings to Miami Marlins for RHP Zach Thompson, RHP Kyle Nicolas and OF Connor Scott. |
| 11/29/21 | Pittsburgh Pirates traded C Jacob Stallings to Miami Marlins for RHP Zach Thompson, RHP Kyle Nicolas and OF Connor Scott. |
| 11/29/21 | Pittsburgh Pirates traded C Jacob Stallings to Miami Marlins for RHP Zach Thompson, RHP Kyle Nicolas and OF Connor Scott. |
| 11/29/21 | Pittsburgh Pirates traded C Jacob Stallings to Miami Marlins for RHP Zach Thompson, RHP Kyle Nicolas and OF Connor Scott. |
| 11/28/21 | Pittsburgh Pirates signed free agent RHP Jerad Eickhoff to a minor league contract. |
| 11/28/21 | Pittsburgh Pirates signed free agent C Jamie Ritchie to a minor league contract. |
| 11/24/21 | Pittsburgh Pirates sent C Michael Perez outright to Indianapolis Indians. |
| 11/19/21 | Pittsburgh Pirates designated C Michael Perez for assignment. |
| 11/19/21 | Pittsburgh Pirates selected the contract of SS Liover Peguero from Greensboro Grasshoppers. |
| 11/19/21 | Pittsburgh Pirates selected the contract of CF Canaan Smith-Njigba from Indianapolis Indians. |
| 11/19/21 | Pittsburgh Pirates selected the contract of CF Jack Suwinski from Altoona Curve. |
| 11/19/21 | Pittsburgh Pirates selected the contract of OF Travis Swaggerty from Indianapolis Indians. |
| 11/16/21 | Pittsburgh Pirates released 3B Taylor Davis. |
| 11/14/21 | RHP Jose Soriano returned to Los Angeles Angels from Pittsburgh Pirates. |
| 11/08/21 | Pittsburgh Pirates signed free agent LHP Nathan Kirby to a minor league contract. |
| 11/07/21 | Pittsburgh Pirates activated SS Diego Castillo. |
| 11/07/21 | Pittsburgh Pirates activated SS Diego Castillo. |
| 11/07/21 | Pittsburgh Pirates designated RHP Jose Soriano for assignment. |
| 11/07/21 | Pittsburgh Pirates selected the contract of SS Diego Castillo from Indianapolis Indians. |
| 11/06/21 | Pittsburgh Pirates activated RHP Jose Soriano. |
| 11/06/21 | Pittsburgh Pirates activated RHP Duane Underwood Jr. from the 60-day injured list. |
| 11/06/21 | Pittsburgh Pirates activated RHP Blake Cederlind from the 60-day injured list. |
| 11/06/21 | Pittsburgh Pirates activated RHP Bryse Wilson from the 60-day injured list. |
| 11/06/21 | Pittsburgh Pirates activated LHP Steven Brault from the 60-day injured list. |
| 11/06/21 | Pittsburgh Pirates activated LHP Dillon Peters from the 60-day injured list. |
| 11/05/21 | Pittsburgh Pirates sent RHP Enyel De Los Santos outright to Indianapolis Indians. |
| 11/05/21 | Pittsburgh Pirates sent RHP Kyle Keller outright to Indianapolis Indians. |
| 11/05/21 | Pittsburgh Pirates sent RHP Connor Overton outright to Indianapolis Indians. |
| 11/05/21 | Pittsburgh Pirates sent RHP Chase De Jong outright to Indianapolis Indians. |
| 11/05/21 | Pittsburgh Pirates sent RHP Shea Spitzbarth outright to Indianapolis Indians. |
| 11/05/21 | Pittsburgh Pirates claimed CF Greg Allen off waivers from New York Yankees. |
| 11/05/21 | LHP Chasen Shreve elected free agency. |
| 11/05/21 | Pittsburgh Pirates sent 2B Wilmer Difo outright to Indianapolis Indians. |
| 11/03/21 | RHP Trevor Cahill elected free agency. |
| 11/03/21 | RHP Shelby Miller elected free agency. |
| 11/03/21 | Pittsburgh Pirates claimed RHP Eric Hanhold off waivers from Baltimore Orioles. |
| 11/03/21 | LF Yoshi Tsutsugo elected free agency. |