DENVER -- It was all set up to be yet another “Troutani” game with superstars Shohei Ohtani and Mike Trout connecting on back-to-back 434-foot blasts to give the Angels a two-run lead over the Rockies in the fifth inning.

The Halos had been 6-0 in games in which both stars homered this season, but that perfect record came to a close in a frustrating way during a 7-4 loss on Friday night in the series opener at Coors Field.

The Angels went 0-for-8 with runners in scoring position and they made several sloppy plays defensively, especially on a potential double-play ball in the eighth inning. The costly error set up a go-ahead grand slam from catcher Elias Díaz.

“You just can’t leave them on base in this park, that’s just the way it is, and we did that a few times,” manager Phil Nevin said. “You have to add on runs here, and we certainly didn’t score enough runs to win in this park.”

With the Angels clinging to a one-run lead in the eighth, they turned to reliever Jacob Webb, but he was removed after recording one out and yielding two singles. Chris Devenski was brought in and he induced a grounder to first base from Ryan McMahon, but Jared Walsh’s throw to shortstop Andrew Velazquez was low and he couldn’t handle it.

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Velazquez was charged with an error that loaded the bases and Díaz made them pay with the go-ahead slam. Walsh, though, took the blame for the feed to second.

“I threw a low cutter and it needs to be a better throw,” Walsh said. “I think if I do that, we could have a double play and the game is totally different. That one is on me.”

It spoiled the Major League-leading 25th homer for Ohtani and the 16th blast for Trout. It also marked the ninth time that Ohtani and Trout had hit consecutive homers, which is tied for the most in franchise history, along with Trout and Albert Pujols.

The duo also has homered in the same game 29 times, which is tied for the second most in Angels history behind only Trout and Pujols, who went deep in the same game 48 times.

Ohtani, who was officially named an All-Star for a third straight year on Thursday after being the leading vote-getter in the American League, had a huge game at the plate, falling just a triple shy of the cycle. He went 3-for-5 and came up to the plate in the eighth looking for that elusive triple, but he struck out on a 3-2 curveball from reliever Pierce Johnson.

It marked the fifth time this season that Ohtani has fallen just one hit short of the cycle.

“He just keeps putting the barrel on the ball,” Nevin said. “He’s hitting every pitch right now and using all fields. He’s obviously somebody we’d like to see up there more and more times.”

Ohtani started his night by lacing a double in the first inning off lefty Kyle Freeland that left the bat at 115.5 mph, but he was stranded there after Trout struck out and Brandon Drury grounded out.

The Angels tallied two runs in the second, keyed by a double from Kevin Padlo, but the Rockies tied it with a run in the second after Jurickson Profar’s leadoff homer in the bottom of the first.

Ohtani, though, gave the Angels the lead with his solo blast off Freeland to open the fifth. Ohtani crushed a 2-1 changeup that was several inches inside, as he was still able to bring his hands in and drive it a Statcast-projected 434 feet over the right-field fence.

"The pitch that Ohtani hit,” Freeland said. “There's only one human being on this planet that has any business swinging at that pitch, and it's him."

It was Ohtani’s 10th homer over his past 16 games and the 200th professional homer of his career (152 in MLB, 48 in Nippon Professional Baseball Organization).

“I'm going to try my best to hit 201 combined homers between the U.S. and Japan tomorrow,” Ohtani said in a statement.

Just four pitches later, Trout jumped all over a 2-1 changeup on the outer half of the zone and drove it a projected 434 feet to center field. It was Trout’s second homer over his past four games, as he’s been trying to shake off an uncharacteristic slump.

But it wasn’t enough, as the bullpen couldn’t hold the lead after lefty Patrick Sandoval gave up three runs on 10 hits and one walk to go with three strikeouts over five-plus innings.

“I trust our bullpen to get things done,” Nevin said. “It just didn’t happen tonight.”