Cubs Roster & Staff
Transactions
| Date | Transaction |
| 12/29/21 | Chicago Cubs signed free agent 2B Dixon Machado to a minor league contract. |
| 12/15/21 | Chicago Cubs signed free agent RHP Mark Leiter Jr. to a minor league contract. |
| 12/03/21 | Chicago Cubs signed free agent LHP Stephen Gonsalves to a minor league contract. |
| 12/01/21 | Chicago Cubs activated RF Michael Hermosillo. |
| 12/01/21 | Chicago Cubs activated LF Clint Frazier. |
| 12/01/21 | Chicago Cubs activated RF Michael Hermosillo. |
| 12/01/21 | Chicago Cubs activated RHP Marcus Stroman. |
| 12/01/21 | Chicago Cubs activated C Yan Gomes. |
| 12/01/21 | Chicago Cubs signed free agent C Yan Gomes. |
| 12/01/21 | Chicago Cubs activated C Yan Gomes. |
| 12/01/21 | Chicago Cubs signed free agent LF Clint Frazier. |
| 12/01/21 | Chicago Cubs activated LF Clint Frazier. |
| 12/01/21 | Chicago Cubs activated RHP Marcus Stroman. |
| 12/01/21 | Chicago Cubs signed free agent RHP Diego Dugarte to a minor league contract. |
| 12/01/21 | Chicago Cubs signed free agent RHP Marcus Stroman. |
| 12/01/21 | Chicago Cubs signed free agent RF Michael Hermosillo. |