Cubs Roster & Staff
Transactions
| Date | Transaction |
| 04/30/22 | Chicago Cubs recalled LHP Locke St. John from Iowa Cubs. |
| 04/30/22 | Chicago Cubs optioned RHP Mark Leiter Jr. to Iowa Cubs. |
| 04/23/22 | Chicago Cubs sent RHP Alec Mills on a rehab assignment to Iowa Cubs. |
| 04/22/22 | Chicago Cubs placed LF Clint Frazier on the 10-day injured list retroactive to April 20, 2022. Appendicitis. |
| 04/22/22 | Chicago Cubs signed free agent C Dilver Gomez to a minor league contract. |
| 04/22/22 | Chicago Cubs signed free agent C Yoanis Aleksandrov to a minor league contract. |
| 04/22/22 | Chicago Cubs sent 1B Greg Deichmann outright to Iowa Cubs. |
| 04/22/22 | Chicago Cubs recalled 1B Alfonso Rivas from Iowa Cubs. |
| 04/21/22 | Chicago Cubs signed free agent RHP Wilber Rodriguez to a minor league contract. |
| 04/21/22 | Chicago Cubs signed free agent OF Joan Delgado to a minor league contract. |
| 04/21/22 | Atlanta Braves traded LHP Sean Newcomb to Chicago Cubs for RHP Jesse Chavez and cash. |
| 04/21/22 | Chicago Cubs traded RHP Cory Abbott to San Francisco Giants. |
| 04/21/22 | Atlanta Braves traded LHP Sean Newcomb to Chicago Cubs for RHP Jesse Chavez and cash. |
| 04/20/22 | Chicago Cubs signed OF Andres Bonolis. |
| 04/19/22 | Chicago Cubs signed free agent RHP Irving Vazquez to a minor league contract. |
| 04/17/22 | Chicago Cubs placed RHP Keegan Thompson on the 15-day injured list. Low back tightness. |
| 04/17/22 | Chicago Cubs activated RHP Keegan Thompson. |
| 04/16/22 | Chicago Cubs designated 1B Greg Deichmann for assignment. |
| 04/16/22 | Chicago Cubs designated RHP Cory Abbott for assignment. |
| 04/16/22 | Chicago Cubs selected the contract of LHP Locke St. John from Iowa Cubs. |
| 04/16/22 | Chicago Cubs optioned 1B Alfonso Rivas to Iowa Cubs. |
| 04/16/22 | Chicago Cubs selected the contract of RHP Mark Leiter Jr. from Iowa Cubs. |
| 04/15/22 | RHP Keegan Thompson roster status changed by Chicago Cubs. |
| 04/15/22 | RHP Keegan Thompson roster status changed by Chicago Cubs. |
| 04/15/22 | RHP Keegan Thompson roster status changed by Chicago Cubs. |
| 04/13/22 | Chicago Cubs signed free agent 2B Elizaul Chalas to a minor league contract. |
| 04/13/22 | Chicago Cubs signed free agent LHP Melvyn Amador to a minor league contract. |
| 04/13/22 | Chicago Cubs signed free agent RHP Wilme Mora to a minor league contract. |
| 04/11/22 | Chicago Cubs activated 1B Alfonso Rivas. |
| 04/07/22 | Chicago Cubs activated RHP Ethan Roberts. |
| 04/05/22 | RHP Samuel Reyes and assigned to Chicago Cubs. |
| 04/05/22 | OF Cole Roederer assigned to Chicago Cubs. |
| 04/05/22 | RHP Gregori Montano roster status changed by Chicago Cubs. |
| 04/05/22 | OF Cole Roederer roster status changed by Chicago Cubs. |
| 04/05/22 | C Ronnier Quintero and assigned to Chicago Cubs. |
| 04/05/22 | RHP Angel Gonzalez and assigned to Chicago Cubs. |
| 04/05/22 | RHP Gregori Montano assigned to Chicago Cubs. |
| 04/05/22 | SS Cristian Hernandez and assigned to Chicago Cubs. |
| 04/05/22 | RHP Luis A. Reyes and assigned to Chicago Cubs. |
| 04/05/22 | 2B Bryan Serra assigned to Chicago Cubs. |
| 04/05/22 | RHP Danis Correa assigned to Chicago Cubs. |
| 04/05/22 | 2B Bryan Serra roster status changed by Chicago Cubs. |
| 04/05/22 | RHP Danis Correa roster status changed by Chicago Cubs. |
| 04/04/22 | Chicago Cubs placed SS Andrelton Simmons on the 10-day injured list. Right shoulder inflammation. |
| 04/04/22 | Chicago Cubs placed RHP Alec Mills on the 10-day injured list. Low back strain. |
| 04/04/22 | Chicago Cubs placed LHP Wade Miley on the 10-day injured list. Left elbow inflammation. |
| 04/04/22 | SS Jake Slaughter roster status changed by Chicago Cubs. |
| 04/04/22 | SS Jake Slaughter assigned to Chicago Cubs. |
| 04/03/22 | CF Kevin Alcantara assigned to Chicago Cubs. |
| 04/03/22 | CF Ismael Mena assigned to Chicago Cubs. |
| 04/03/22 | CF Ismael Mena roster status changed by Chicago Cubs. |
| 04/03/22 | CF Kevin Alcantara roster status changed by Chicago Cubs. |
| 04/03/22 | SS Luis Vazquez and assigned to Chicago Cubs. |
| 04/03/22 | Chicago Cubs optioned RHP Manuel Rodriguez to Iowa Cubs. |
| 04/02/22 | Chicago Cubs activated RHP Jesse Chavez. |
| 04/02/22 | Chicago Cubs activated RHP Jesse Chavez. |
| 04/02/22 | Chicago Cubs selected the contract of RHP Jesse Chavez from Iowa Cubs. |
| 04/01/22 | SS Christian Olivo and assigned to Chicago Cubs. |
| 04/01/22 | OF Nelson Velazquez assigned to Chicago Cubs. |
| 04/01/22 | SS Pedro Ramirez and assigned to Chicago Cubs. |
| 04/01/22 | SS Christopher Morel assigned to Chicago Cubs. |
| 04/01/22 | LHP Dalton Stambaugh and assigned to Chicago Cubs. |