Cubs Roster & Staff
Transactions
| Date | Transaction |
| 05/31/22 | Chicago Cubs signed free agent RHP Adrian Sampson to a minor league contract. |
| 05/31/22 | Chicago Cubs activated 2B Nick Madrigal. |
| 05/31/22 | Chicago Cubs optioned RHP Anderson Espinoza to Iowa Cubs. |
| 05/30/22 | Chicago Cubs designated RHP Robert Gsellman for assignment. |
| 05/30/22 | Chicago Cubs placed SS Jonathan Villar on the 10-day injured list retroactive to May 27, 2022. Mouth injury. |
| 05/30/22 | Chicago Cubs transferred RHP Ethan Roberts from the 10-day injured list to the 60-day injured list. Right shoulder inflammation. |
| 05/30/22 | Chicago Cubs selected the contract of RHP Matt Swarmer from Iowa Cubs. |
| 05/30/22 | Chicago Cubs selected the contract of CF Brandon Hughes from Iowa Cubs. |
| 05/30/22 | Chicago Cubs recalled OF Nelson Velazquez from Iowa Cubs. |
| 05/30/22 | Chicago Cubs recalled RHP Anderson Espinoza from Tennessee Smokies. |
| 05/29/22 | Chicago Cubs placed RHP Chris Martin on the bereavement list. |
| 05/29/22 | Chicago Cubs recalled RHP Mark Leiter Jr. from Iowa Cubs. |
| 05/28/22 | Chicago Cubs sent RHP Michael Rucker on a rehab assignment to Iowa Cubs. |
| 05/28/22 | Chicago Cubs activated LF Clint Frazier. |
| 05/28/22 | Chicago Cubs sent 2B Nick Madrigal on a rehab assignment to Iowa Cubs. |
| 05/28/22 | Chicago Cubs optioned CF Brandon Hughes to Iowa Cubs. |
| 05/27/22 | Chicago Cubs placed OF Seiya Suzuki on the 10-day injured list. Left ring finger sprain. |
| 05/26/22 | 2B Ildemaro Vargas elected free agency. |
| 05/25/22 | Chicago Cubs activated 2B Nico Hoerner from the 10-day injured list. |
| 05/25/22 | Chicago Cubs placed C Yan Gomes on the 10-day injured list retroactive to May 24, 2022. Left oblique strain. |
| 05/24/22 | Chicago Cubs sent LHP Sean Newcomb on a rehab assignment to Iowa Cubs. |
| 05/22/22 | Chicago Cubs designated 2B Ildemaro Vargas for assignment. |
| 05/22/22 | Chicago Cubs activated C P.J. Higgins. |
| 05/22/22 | Chicago Cubs selected the contract of C P.J. Higgins from Iowa Cubs. |
| 05/19/22 | Chicago Cubs sent 2B David Bote on a rehab assignment to Iowa Cubs. |
| 05/19/22 | Chicago Cubs activated RHP Marcus Stroman from the 10-day injured list. |
| 05/19/22 | Chicago Cubs placed RHP Michael Rucker on the 15-day injured list retroactive to May 17, 2022. Left turf toe. |
| 05/19/22 | Chicago Cubs placed RHP Alec Mills on the 60-day injured list. Right quadriceps strain. |
| 05/19/22 | Chicago Cubs sent 2B David Bote on a rehab assignment to Iowa Cubs. |
| 05/18/22 | Chicago Cubs activated RHP David Robertson from the 10-day injured list. |
| 05/18/22 | Chicago Cubs signed free agent RHP Alfredo Romero. |
| 05/18/22 | Chicago Cubs signed free agent OF Erbin Jaque to a minor league contract. |
| 05/18/22 | Chicago Cubs optioned RHP Mark Leiter Jr. to Iowa Cubs. |
| 05/17/22 | Chicago Cubs placed RF Jason Heyward on the 10-day injured list. |
| 05/17/22 | Chicago Cubs sent LF Clint Frazier on a rehab assignment to Iowa Cubs. |
| 05/17/22 | Chicago Cubs activated SS Christopher Morel. |
| 05/17/22 | Chicago Cubs selected the contract of CF Brandon Hughes from Iowa Cubs. |
| 05/17/22 | Chicago Cubs optioned LHP Conner Menez to Iowa Cubs. |
| 05/17/22 | Chicago Cubs recalled SS Christopher Morel from Tennessee Smokies. |
| 05/15/22 | Chicago Cubs placed 2B Nico Hoerner on the 10-day injured list retroactive to May 12, 2022. Right ankle sprain. |
| 05/15/22 | Chicago Cubs activated SS Andrelton Simmons. |
| 05/13/22 | Seattle Mariners claimed RHP Adrian Sampson off waivers from Chicago Cubs. |
| 05/11/22 | Chicago Cubs placed LHP Sean Newcomb on the 15-day injured list retroactive to May 8, 2022. Left ankle sprain. |
| 05/11/22 | Chicago Cubs recalled RHP Mark Leiter Jr. from Iowa Cubs. |
| 05/10/22 | Chicago Cubs placed LHP Wade Miley on the 15-day injured list. Left shoulder strain. |
| 05/10/22 | Chicago Cubs activated LHP Wade Miley. |
| 05/10/22 | Chicago Cubs designated RHP Adrian Sampson for assignment. |
| 05/10/22 | Chicago Cubs placed 2B Nick Madrigal on the 10-day injured list. Low back strain. |
| 05/10/22 | Chicago Cubs selected the contract of 2B Ildemaro Vargas from Iowa Cubs. |
| 05/10/22 | New York Mets claimed LHP Locke St. John off waivers from Chicago Cubs. |
| 05/09/22 | Chicago Cubs placed 1B Frank Schwindel on the 10-day injured list. Lower back strain. |
| 05/09/22 | Chicago Cubs activated 1B Frank Schwindel. |
| 05/09/22 | Chicago Cubs placed RHP David Robertson on the 10-day injured list. |
| 05/09/22 | Chicago Cubs selected the contract of LHP Conner Menez from Iowa Cubs. |
| 05/09/22 | Chicago Cubs recalled 1B Frank Schwindel from Iowa Cubs. |
| 05/09/22 | Chicago Cubs optioned RHP Adrian Sampson to Iowa Cubs. |
| 05/08/22 | Chicago Cubs placed RHP Marcus Stroman on the 10-day injured list. |
| 05/08/22 | Chicago Cubs placed RF Michael Hermosillo on the 10-day injured list. Left quadriceps strain. |
| 05/08/22 | Chicago Cubs signed free agent RHP Luke Farrell to a minor league contract. |
| 05/08/22 | Chicago Cubs optioned 1B Frank Schwindel to Iowa Cubs. |
| 05/08/22 | Chicago Cubs selected the contract of RHP Adrian Sampson from Iowa Cubs. |
| 05/07/22 | Chicago Cubs sent SS Andrelton Simmons on a rehab assignment to Iowa Cubs. |
| 05/07/22 | Chicago Cubs activated LHP Drew Smyly from the bereavement list. |
| 05/05/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to Iowa Cubs. |
| 05/03/22 | Chicago Cubs placed LHP Drew Smyly on the bereavement list. |
| 05/03/22 | Chicago Cubs designated LHP Locke St. John for assignment. |
| 05/03/22 | Chicago Cubs selected the contract of RHP Robert Gsellman from Iowa Cubs. |
| 05/02/22 | Chicago Cubs placed RHP Ethan Roberts on the 10-day injured list retroactive to April 30, 2022. Right shoulder inflammation. |
| 05/02/22 | Chicago Cubs signed free agent RHP Yoendris Gonzalez to a minor league contract. |
| 05/02/22 | Chicago Cubs optioned LHP Locke St. John to Iowa Cubs. |