Cubs Roster & Staff
Transactions
| Date | Transaction |
| 06/30/22 | Chicago Cubs placed RF Jason Heyward on the 10-day injured list retroactive to June 27, 2022. Right knee inflammation. |
| 06/30/22 | Chicago Cubs transferred RF Michael Hermosillo from the 10-day injured list to the 60-day injured list. |
| 06/30/22 | Chicago Cubs sent OF Seiya Suzuki on a rehab assignment to Iowa Cubs. |
| 06/28/22 | Chicago Cubs released SS Jonathan Villar. |
| 06/24/22 | Chicago Cubs activated 2B David Bote. |
| 06/24/22 | Chicago Cubs designated SS Jonathan Villar for assignment. |
| 06/23/22 | Chicago Cubs placed LHP Daniel Norris on the 15-day injured list. Left index finger strain. |
| 06/23/22 | Chicago Cubs recalled RHP Adrian Sampson from Iowa Cubs. |
| 06/21/22 | Chicago Cubs traded LHP Eric Stout to Pittsburgh Pirates for cash. |
| 06/21/22 | Chicago Cubs optioned RHP Caleb Kilian to Iowa Cubs. |
| 06/21/22 | Chicago Cubs recalled RHP Mark Leiter Jr. from Iowa Cubs. |
| 06/20/22 | Chicago Cubs optioned RHP Adrian Sampson to Iowa Cubs. |
| 06/20/22 | Chicago Cubs recalled OF Nelson Velazquez, , , and from Iowa Cubs. |
| 06/20/22 | Chicago Cubs sent LHP Sean Newcomb outright to Iowa Cubs. |
| 06/19/22 | Chicago Cubs sent RHP Ethan Roberts on a rehab assignment to Iowa Cubs. |
| 06/18/22 | Chicago Cubs placed 1B Frank Schwindel on the 10-day injured list. Low back strain. |
| 06/18/22 | Chicago Cubs recalled 1B Alfonso Rivas from Iowa Cubs. |
| 06/17/22 | Chicago Cubs sent 2B David Bote on a rehab assignment to Iowa Cubs. |
| 06/17/22 | Chicago Cubs sent LF Clint Frazier outright to Iowa Cubs. |
| 06/16/22 | Chicago Cubs designated LHP Eric Stout for assignment. |
| 06/16/22 | Chicago Cubs selected the contract of RHP Adrian Sampson from Iowa Cubs. |
| 06/15/22 | Chicago Cubs placed 2B Nick Madrigal on the 10-day injured list retroactive to June 12, 2022. Left groin strain. |
| 06/15/22 | Chicago Cubs recalled RHP Caleb Kilian from Iowa Cubs. |
| 06/13/22 | Chicago Cubs designated LHP Sean Newcomb for assignment. |
| 06/13/22 | Chicago Cubs selected the contract of LHP Eric Stout from Iowa Cubs. |
| 06/12/22 | Chicago Cubs activated LHP Sean Newcomb. |
| 06/12/22 | Chicago Cubs optioned RHP Michael Rucker to Iowa Cubs. |
| 06/11/22 | Chicago Cubs recalled RHP Michael Rucker from Iowa Cubs. |
| 06/10/22 | Chicago Cubs designated LF Clint Frazier for assignment. |
| 06/10/22 | Chicago Cubs activated C Yan Gomes from the 10-day injured list. |
| 06/10/22 | Chicago Cubs activated LHP Wade Miley from the 15-day injured list. |
| 06/10/22 | Chicago Cubs activated RHP Chris Martin from the restricted list. |
| 06/10/22 | Chicago Cubs activated SS Jonathan Villar from the 10-day injured list. |
| 06/10/22 | Chicago Cubs placed RHP Marcus Stroman on the 15-day injured list retroactive to June 7, 2022. Right shoulder inflammation. |
| 06/10/22 | Chicago Cubs optioned RHP Michael Rucker to Iowa Cubs. |
| 06/10/22 | Chicago Cubs optioned 1B Alfonso Rivas to Iowa Cubs. |
| 06/07/22 | Chicago Cubs activated RHP Alec Mills from the 60-day injured list. |
| 06/07/22 | Chicago Cubs optioned RHP Anderson Espinoza to Tennessee Smokies. |
| 06/06/22 | Chicago Cubs sent LHP Conner Menez outright to Iowa Cubs. |
| 06/05/22 | Chicago Cubs placed RHP Chris Martin on the restricted list. |
| 06/05/22 | Chicago Cubs optioned RHP Caleb Kilian to Iowa Cubs. |
| 06/04/22 | Chicago Cubs designated LHP Conner Menez for assignment. |
| 06/04/22 | Chicago Cubs optioned RHP Mark Leiter Jr. to Iowa Cubs. |
| 06/04/22 | Chicago Cubs recalled RHP Anderson Espinoza from Tennessee Smokies. |
| 06/04/22 | Chicago Cubs selected the contract of RHP Caleb Kilian from Iowa Cubs. |
| 06/03/22 | Chicago Cubs signed free agent RHP Fraimin Marte to a minor league contract. |
| 06/03/22 | Chicago Cubs signed free agent RHP Stanley Guzman to a minor league contract. |
| 06/03/22 | Chicago Cubs signed free agent RHP Abel Moya to a minor league contract. |
| 06/02/22 | Chicago Cubs sent RHP Robert Gsellman outright to Iowa Cubs. |
| 06/01/22 | Chicago Cubs placed LHP Drew Smyly on the 15-day injured list retroactive to May 31, 2022. Right oblique strain. |
| 06/01/22 | Chicago Cubs activated RHP Michael Rucker. |
| 06/01/22 | Chicago Cubs placed RHP Manuel Rodriguez on the 60-day injured list. Right elbow strain. |
| 06/01/22 | Chicago Cubs activated RF Jason Heyward from the 10-day injured list. |
| 06/01/22 | Chicago Cubs recalled RHP Manuel Rodriguez from Iowa Cubs. |
| 06/01/22 | Chicago Cubs optioned OF Nelson Velazquez to Iowa Cubs. |