Cubs Roster & Staff
Transactions
| Date | Transaction |
| 07/31/22 | RHP Raynel Espinal roster status changed by Chicago Cubs. |
| 07/31/22 | Chicago Cubs activated 2B Zach McKinstry. |
| 07/31/22 | Chicago Cubs optioned 1B Alfonso Rivas to Iowa Cubs. |
| 07/31/22 | Chicago Cubs traded 2B Dixon Machado to San Francisco Giants for RHP Raynel Espinal. |
| 07/31/22 | Chicago Cubs traded 2B Dixon Machado to San Francisco Giants for RHP Raynel Espinal. |
| 07/30/22 | Chicago Cubs signed RHP Garrett Brown. |
| 07/30/22 | Chicago Cubs signed LHP Branden Noriega. |
| 07/30/22 | RHP Nazier Mule roster status changed by Chicago Cubs. |
| 07/30/22 | Chicago Cubs signed RHP Nazier Mule. |
| 07/30/22 | Chicago Cubs signed RHP Mathew Peters. |
| 07/30/22 | Chicago Cubs signed RHP Shane Marshall. |
| 07/30/22 | Chicago Cubs signed OF Ke'Shun Collier. |
| 07/30/22 | Chicago Cubs signed RHP Luis Rujano. |
| 07/30/22 | Chicago Cubs signed RHP JP Wheat. |
| 07/30/22 | Chicago Cubs signed C Haydn McGeary. |
| 07/30/22 | Chicago Cubs signed OF Andy Garriola. |
| 07/30/22 | Chicago Cubs traded RHP Chris Martin to Los Angeles Dodgers for 2B Zach McKinstry. |
| 07/30/22 | Chicago Cubs recalled RHP Mark Leiter Jr. from Iowa Cubs. |
| 07/30/22 | Chicago Cubs traded RHP Chris Martin to Los Angeles Dodgers for 2B Zach McKinstry. |
| 07/29/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to South Bend Cubs. |
| 07/29/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to South Bend Cubs. |
| 07/29/22 | Chicago Cubs signed LHP Jackson Ferris. |
| 07/28/22 | Chicago Cubs sent SS Andrelton Simmons on a rehab assignment to Iowa Cubs. |
| 07/28/22 | Chicago Cubs sent SS Andrelton Simmons on a rehab assignment to Iowa Cubs. |
| 07/23/22 | Chicago Cubs signed RHP Mason McGwire. |
| 07/23/22 | Chicago Cubs signed RHP Brandon Birdsell. |
| 07/23/22 | Chicago Cubs signed free agent RHP Nick Hull to a minor league contract. |
| 07/23/22 | Chicago Cubs signed SS Christopher Paciolla. |
| 07/23/22 | Chicago Cubs signed RHP Will Frisch. |
| 07/23/22 | Chicago Cubs signed RHP Brody McCullough. |
| 07/23/22 | Chicago Cubs signed RHP Connor Noland. |
| 07/23/22 | Chicago Cubs signed RHP Cade Horton. |
| 07/22/22 | Chicago Cubs sent 2B Nick Madrigal on a rehab assignment to Iowa Cubs. |
| 07/22/22 | Chicago Cubs released LHP Daniel Norris. |
| 07/21/22 | Chicago Cubs sent RHP Matt Swarmer outright to Iowa Cubs. |
| 07/17/22 | Chicago Cubs designated LHP Daniel Norris for assignment. |
| 07/17/22 | Chicago Cubs selected the contract of RHP Erich Uelmen from Iowa Cubs. |
| 07/17/22 | Chicago Cubs optioned RHP Anderson Espinoza to Iowa Cubs. |
| 07/16/22 | Chicago Cubs designated RHP Matt Swarmer for assignment. |
| 07/16/22 | Chicago Cubs optioned RHP Mark Leiter Jr. to Iowa Cubs. |
| 07/16/22 | Chicago Cubs recalled RHP Anderson Espinoza from Iowa Cubs. |
| 07/16/22 | Chicago Cubs selected the contract of LHP Steven Brault from Iowa Cubs. |
| 07/14/22 | Chicago Cubs placed SS Andrelton Simmons on the 10-day injured list retroactive to July 11, 2022. Right shoulder strain. |
| 07/14/22 | Chicago Cubs activated 1B Frank Schwindel. |
| 07/13/22 | Chicago Cubs activated LHP Daniel Norris. |
| 07/13/22 | Chicago Cubs optioned RHP Matt Swarmer to Iowa Cubs. |
| 07/12/22 | Chicago Cubs activated LHP Justin Steele from the paternity list. |
| 07/12/22 | Chicago Cubs optioned RHP Anderson Espinoza to Iowa Cubs. |
| 07/10/22 | Chicago Cubs activated LHP Drew Smyly. |
| 07/10/22 | Chicago Cubs optioned RHP Michael Rucker to Iowa Cubs. |
| 07/09/22 | Chicago Cubs placed LHP Justin Steele on the paternity list. |
| 07/09/22 | Chicago Cubs activated RHP Marcus Stroman from the 15-day injured list. |
| 07/08/22 | Chicago Cubs sent 1B Frank Schwindel on a rehab assignment to Iowa Cubs. |
| 07/07/22 | Chicago Cubs sent LHP Daniel Norris on a rehab assignment to Iowa Cubs. |
| 07/07/22 | Chicago Cubs sent 2B Nick Madrigal on a rehab assignment to Iowa Cubs. |
| 07/06/22 | Chicago Cubs placed RHP Kyle Hendricks on the 15-day injured list. Right shoulder strain. |
| 07/06/22 | Chicago Cubs recalled RHP Anderson Espinoza from Tennessee Smokies. |
| 07/05/22 | Chicago Cubs signed free agent RHP Charbel Gonzalez to a minor league contract. |
| 07/04/22 | Chicago Cubs sent LHP Drew Smyly on a rehab assignment to South Bend Cubs. |
| 07/04/22 | Chicago Cubs activated OF Seiya Suzuki. |
| 07/04/22 | Chicago Cubs selected the contract of CF Narciso Crook and from Iowa Cubs. |
| 07/04/22 | Chicago Cubs optioned CF Narciso Crook to Iowa Cubs. |
| 07/03/22 | Chicago Cubs sent RHP Marcus Stroman on a rehab assignment to Iowa Cubs. |
| 07/03/22 | Chicago Cubs placed RHP Alec Mills on the 15-day injured list. Low back strain. |
| 07/03/22 | Chicago Cubs recalled RHP Michael Rucker from Iowa Cubs. |