D-backs Roster & Staff
Transactions
| Date | Transaction |
| 12/22/21 | Arizona Diamondbacks signed free agent RF Roby Enriquez to a minor league contract. |
| 12/20/21 | Arizona Diamondbacks signed free agent RHP Matt Cleveland to a minor league contract. |
| 12/15/21 | Arizona Diamondbacks signed free agent LHP Yu-Min Lin to a minor league contract. |
| 12/15/21 | Arizona Diamondbacks signed free agent RHP Santiago Ramirez to a minor league contract. |
| 12/14/21 | Arizona Diamondbacks signed free agent RHP Alfred Morillo to a minor league contract. |
| 12/14/21 | Arizona Diamondbacks signed free agent RHP Christian Montes De Oca to a minor league contract. |
| 12/01/21 | Arizona Diamondbacks activated RHP Mark Melancon. |
| 12/01/21 | Arizona Diamondbacks activated RHP Mark Melancon. |
| 12/01/21 | Arizona Diamondbacks signed free agent RHP Mark Melancon. |
| 12/01/21 | RHP Keynan Middleton roster status changed by Arizona Diamondbacks. |
| 12/01/21 | Arizona Diamondbacks signed free agent RHP Keynan Middleton. |
| 12/01/21 | Arizona Diamondbacks sent 2B Andrew Young outright to Amarillo Sod Poodles. |
| 12/01/21 | Arizona Diamondbacks sent RHP Brett de Geus outright to Reno Aces. |