White Sox Roster & Staff
Transactions
| Date | Transaction |
| 04/30/22 | Chicago White Sox sent 2B Yoan Moncada on a rehab assignment to Charlotte Knights. |
| 04/29/22 | Chicago White Sox signed free agent RHP Rafael Dolis to a minor league contract. |
| 04/29/22 | Chicago White Sox activated RHP Ryan Burr. |
| 04/29/22 | Chicago White Sox optioned RHP Kyle Crick to Charlotte Knights. |
| 04/26/22 | Chicago White Sox activated RHP Matt Foster. |
| 04/26/22 | Chicago White Sox optioned CF Adam Haseley to Charlotte Knights. |
| 04/24/22 | Chicago White Sox placed LF Eloy Jimenez on the 10-day injured list. Right hamstring strain. |
| 04/24/22 | Chicago White Sox activated RHP Lucas Giolito from the 10-day injured list. |
| 04/23/22 | Chicago White Sox sent RHP Ryan Burr on a rehab assignment to Charlotte Knights. |
| 04/22/22 | Chicago White Sox activated CF AJ Pollock from the 10-day injured list. |
| 04/22/22 | RHP Matt Foster roster status changed by Chicago White Sox. |
| 04/21/22 | Chicago White Sox optioned RHP Jimmy Lambert to Charlotte Knights. |
| 04/21/22 | Chicago White Sox traded LHP Garvin Alston to Washington Nationals. |
| 04/20/22 | Chicago White Sox recalled CF Adam Haseley from Charlotte Knights. |
| 04/12/22 | Chicago White Sox placed RHP Lucas Giolito on the 10-day injured list retroactive to April 9, 2022. Abdominal strain. |
| 04/12/22 | Chicago White Sox placed CF AJ Pollock on the 10-day injured list retroactive to April 10, 2022. Strained right hamstring. |
| 04/12/22 | Chicago White Sox recalled LHP Anderson Severino, and from Charlotte Knights. |
| 04/12/22 | Chicago White Sox recalled RHP Jimmy Lambert, and from Charlotte Knights. |
| 04/10/22 | Chicago White Sox activated SS Tim Anderson. |
| 04/10/22 | Chicago White Sox sent RF Micker Adolfo outright to Charlotte Knights. |
| 04/09/22 | RHP Scott Blewett roster status changed by Chicago White Sox. |
| 04/09/22 | Chicago White Sox signed free agent RHP Scott Blewett to a minor league contract. |
| 04/08/22 | Chicago White Sox signed free agent RHP Johnny Cueto to a minor league contract. |
| 04/08/22 | LHP Tommy Sommer assigned to Chicago White Sox. |
| 04/08/22 | SS Tim Anderson roster status changed by Chicago White Sox. |
| 04/07/22 | Chicago White Sox activated RHP Kyle Crick. |
| 04/07/22 | Chicago White Sox signed free agent RHP Kyle Crick. |
| 04/07/22 | Chicago White Sox activated LHP Tanner Banks. |
| 04/07/22 | Chicago White Sox activated LHP Tanner Banks. |
| 04/07/22 | Chicago White Sox signed free agent SS Jason Matthews to a minor league contract. |
| 04/07/22 | Chicago White Sox signed free agent C Keegan Fish to a minor league contract. |
| 04/07/22 | Chicago White Sox activated RHP Kyle Crick. |
| 04/07/22 | Chicago White Sox designated RF Micker Adolfo for assignment. |
| 04/07/22 | Chicago White Sox recalled RHP Matt Foster, and from Charlotte Knights. |
| 04/07/22 | Chicago White Sox recalled 3B Jake Burger, and from Charlotte Knights. |
| 04/07/22 | Chicago White Sox sent C Seby Zavala outright to Charlotte Knights. |
| 04/07/22 | Chicago White Sox selected the contract of LHP Tanner Banks from Charlotte Knights. |
| 04/05/22 | RHP Angel Acevedo assigned to Chicago White Sox. |
| 04/05/22 | C Nick Thornquist and assigned to Chicago White Sox. |
| 04/05/22 | RHP Angel Acevedo roster status changed by Chicago White Sox. |
| 04/04/22 | Chicago White Sox placed RHP Ryan Burr on the 10-day injured list. Right shoulder strain. |
| 04/04/22 | Chicago White Sox placed C Yermin Mercedes on the 10-day injured list. Left hamate fracture. |
| 04/04/22 | Chicago White Sox placed LHP Garrett Crochet on the 10-day injured list. Left elbow surgery. |
| 04/04/22 | Chicago White Sox placed 2B Yoan Moncada on the 10-day injured list. Right oblique strain. |
| 04/04/22 | Chicago White Sox placed RHP Joe Kelly on the 10-day injured list. Right biceps nerve injury. |
| 04/04/22 | RHP Felix Paulino and assigned to Chicago White Sox. |
| 04/04/22 | Chicago White Sox placed RHP Lance Lynn on the 10-day injured list. Right knee surgery to repair torn tendon. |
| 04/04/22 | Chicago White Sox optioned LHP Anderson Severino to Charlotte Knights. |
| 04/03/22 | Chicago White Sox released CF Joel Booker. |
| 04/03/22 | Chicago White Sox activated C Reese McGuire. |
| 04/03/22 | RHP Everhett Hazelwood and assigned to Chicago White Sox. |
| 04/03/22 | Chicago White Sox signed free agent SS Ryan Burrowes to a minor league contract. |
| 04/03/22 | Chicago White Sox released RHP Jake Elliott. |
| 04/03/22 | Chicago White Sox activated C Reese McGuire. |
| 04/03/22 | Toronto Blue Jays traded C Reese McGuire to Chicago White Sox for C Zack Collins. |
| 04/03/22 | Toronto Blue Jays traded C Reese McGuire to Chicago White Sox for C Zack Collins. |
| 04/03/22 | Chicago White Sox optioned 3B Romy Gonzalez to Charlotte Knights. |
| 04/02/22 | RHP Brian Glowicki and assigned to Chicago White Sox. |
| 04/02/22 | Chicago White Sox sent CF Blake Rutherford outright to Charlotte Knights. |
| 04/01/22 | Chicago White Sox signed free agent RHP Jose Rodulfo to a minor league contract. |
| 04/01/22 | Chicago White Sox optioned C Zack Collins to Charlotte Knights. |
| 04/01/22 | Chicago White Sox optioned RHP Matt Foster to Charlotte Knights. |
| 04/01/22 | Chicago White Sox optioned CF Adam Haseley to Charlotte Knights. |
| 04/01/22 | Chicago White Sox traded RHP Craig Kimbrel to Los Angeles Dodgers for CF AJ Pollock. |
| 04/01/22 | Chicago White Sox traded RHP Craig Kimbrel to Los Angeles Dodgers for CF AJ Pollock. |
| 04/01/22 | Chicago White Sox optioned 3B Jake Burger to Charlotte Knights. |