Astros Roster & Staff
Transactions
| Date | Transaction |
| 05/25/22 | Houston Astros signed free agent RHP Luis Victorino to a minor league contract. |
| 05/24/22 | Houston Astros activated RHP Bryan Abreu. |
| 05/23/22 | Houston Astros signed free agent RHP Franklin Gil to a minor league contract. |
| 05/20/22 | Houston Astros signed free agent RHP Wilmy Sanchez to a minor league contract. |
| 05/20/22 | Houston Astros signed free agent OF Rabel Colon to a minor league contract. |
| 05/19/22 | Houston Astros signed free agent LHP Geremy Guerrero to a minor league contract. |
| 05/17/22 | Houston Astros placed RHP Jake Odorizzi on the 15-day injured list. Lower left leg discomfort. |
| 05/17/22 | Houston Astros recalled RHP Seth Martinez from Sugar Land Space Cowboys. |
| 05/16/22 | Houston Astros signed free agent C Andrews Sosa to a minor league contract. |
| 05/15/22 | Houston Astros activated 1B Niko Goodrum. |
| 05/15/22 | Houston Astros activated SS Mauricio Dubon. |
| 05/15/22 | Houston Astros activated SS Mauricio Dubón. |
| 05/15/22 | Houston Astros optioned 1B Niko Goodrum to Sugar Land Space Cowboys. |
| 05/14/22 | San Francisco Giants traded SS Mauricio Dubon to Houston Astros for C Michael Papierski. |
| 05/14/22 | San Francisco Giants traded SS Mauricio Dubon to Houston Astros for C Michael Papierski. |
| 05/13/22 | Houston Astros optioned RHP Seth Martinez to Sugar Land Space Cowboys. |
| 05/12/22 | Houston Astros recalled RHP Seth Martinez from Sugar Land Space Cowboys. |
| 05/11/22 | Houston Astros signed free agent C Carlos Cauro to a minor league contract. |
| 05/09/22 | Houston Astros signed free agent C Kedaur Trujillo to a minor league contract. |
| 05/05/22 | Houston Astros activated RHP Ryan Pressly. |
| 05/05/22 | Houston Astros optioned LHP Parker Mushinski to Sugar Land Space Cowboys. |
| 05/03/22 | Houston Astros sent RHP Ryan Pressly on a rehab assignment to Sugar Land Space Cowboys. |
| 05/02/22 | Houston Astros activated 2B Jose Altuve from the 10-day injured list. |
| 05/02/22 | Houston Astros placed 2B Jose Altuve on the 10-day injured list. Right thumb fracture. |
| 05/02/22 | Houston Astros optioned RHP Seth Martinez to Sugar Land Space Cowboys. |
| 05/02/22 | Houston Astros optioned RHP Ronel Blanco to Sugar Land Space Cowboys. |
| 05/02/22 | Houston Astros optioned 1B J.J. Matijevic to Sugar Land Space Cowboys. |