Cubs Roster & Staff
Transactions
| Date | Transaction |
| 03/30/22 | RHP Eury Ramos roster status changed by Chicago Cubs. |
| 03/30/22 | SS Luis Verdugo roster status changed by Chicago Cubs. |
| 03/30/22 | RHP Eury Ramos assigned to Chicago Cubs. |
| 03/30/22 | SS Luis Verdugo assigned to Chicago Cubs. |
| 03/30/22 | OF Ezequiel Pagan and assigned to Chicago Cubs. |
| 03/29/22 | RHP Kyle Johnson roster status changed by Chicago Cubs. |
| 03/29/22 | SS Scott McKeon and assigned to Chicago Cubs. |
| 03/29/22 | C Jake Washer and assigned to Chicago Cubs. |
| 03/29/22 | 3B BJ Murray Jr. and assigned to Chicago Cubs. |
| 03/29/22 | RHP Kyle Johnson assigned to Chicago Cubs. |
| 03/28/22 | C Caleb Knight and assigned to Chicago Cubs. |
| 03/28/22 | Chicago Cubs optioned C Miguel Amaya to Tennessee Smokies. |
| 03/27/22 | Miami Marlins claimed RHP Tommy Nance off waivers from Chicago Cubs. |
| 03/27/22 | Chicago Cubs traded SS Sergio Alcantara to Arizona Diamondbacks for cash. |
| 03/26/22 | OF Edmond Americaan assigned to Chicago Cubs. |
| 03/26/22 | RHP Javier Assad assigned to Chicago Cubs. |
| 03/26/22 | OF Edmond Americaan roster status changed by Chicago Cubs. |
| 03/26/22 | RHP Javier Assad roster status changed by Chicago Cubs. |
| 03/25/22 | CF Brandon Hughes and assigned to Chicago Cubs. |
| 03/25/22 | Chicago Cubs designated RHP Tommy Nance for assignment. |
| 03/25/22 | Chicago Cubs traded RF Harold Ramirez to Tampa Bay Rays for 3B Esteban Quiroz. |
| 03/25/22 | Chicago Cubs optioned 1B Greg Deichmann to Iowa Cubs. |
| 03/25/22 | Chicago Cubs optioned RHP Anderson Espinoza to Tennessee Smokies. |
| 03/25/22 | Chicago Cubs optioned LHP Brailyn Marquez to Tennessee Smokies. |
| 03/25/22 | Chicago Cubs optioned RHP Cory Abbott to Iowa Cubs. |
| 03/25/22 | Chicago Cubs traded RF Harold Ramirez to Tampa Bay Rays for 3B Esteban Quiroz. |
| 03/24/22 | 3B James Triantos roster status changed by Chicago Cubs. |
| 03/24/22 | IF Cam Balego roster status changed by Chicago Cubs. |
| 03/24/22 | 3B James Triantos assigned to Chicago Cubs. |
| 03/24/22 | IF Cam Balego assigned to Chicago Cubs. |
| 03/24/22 | SS Reginald Preciado assigned to Chicago Cubs. |
| 03/24/22 | SS Reginald Preciado roster status changed by Chicago Cubs. |
| 03/23/22 | Chicago Cubs signed free agent RHP Mychal Givens, and. |
| 03/23/22 | Chicago Cubs designated SS Sergio Alcantara for assignment. |
| 03/22/22 | Chicago Cubs signed free agent LHP Steven Brault and to a minor league contract. |
| 03/21/22 | LHP Wyatt Short roster status changed by Chicago Cubs. |
| 03/21/22 | LHP Wyatt Short assigned to Chicago Cubs. |
| 03/21/22 | Chicago Cubs signed free agent RHP Robert Gsellman and to a minor league contract and invited him to spring training. |
| 03/21/22 | RHP Erich Uelmen and assigned to Chicago Cubs. |
| 03/20/22 | RHP Jarod Wright and assigned to Chicago Cubs. |
| 03/20/22 | RHP Matt Swarmer assigned to Chicago Cubs. |
| 03/20/22 | Chicago Cubs signed free agent 2B Robel Garcia to a minor league contract and invited him to spring training. |
| 03/20/22 | RHP Matt Swarmer roster status changed by Chicago Cubs. |
| 03/20/22 | 2B Robel Garcia roster status changed by Chicago Cubs. |
| 03/19/22 | RHP Kevin McCarthy roster status changed by Chicago Cubs. |
| 03/19/22 | Chicago Cubs activated SS Jonathan Villar. |
| 03/19/22 | Chicago Cubs activated LHP Daniel Norris. |
| 03/19/22 | LHP Scott Kobos and assigned to Chicago Cubs. |
| 03/19/22 | Chicago Cubs placed 2B David Bote on the 60-day injured list. Left shoulder surgery. |
| 03/19/22 | Chicago Cubs activated SS Jonathan Villar. |
| 03/19/22 | Chicago Cubs signed free agent SS Jonathan Villar. |
| 03/19/22 | Chicago Cubs placed RHP Tommy Nance on the 10-day injured list. |
| 03/19/22 | RHP Walker Powell assigned to Chicago Cubs. |
| 03/19/22 | Chicago Cubs activated LHP Drew Smyly. |
| 03/19/22 | RHP Kevin McCarthy assigned to Chicago Cubs. |
| 03/19/22 | LHP Bryan Hudson roster status changed by Chicago Cubs. |
| 03/19/22 | Chicago Cubs signed free agent LHP Daniel Norris. |
| 03/19/22 | Chicago Cubs activated LHP Daniel Norris. |
| 03/19/22 | Chicago Cubs signed free agent LHP Drew Smyly. |
| 03/19/22 | 2B Bryce Windham assigned to Chicago Cubs. |
| 03/19/22 | RHP Walker Powell roster status changed by Chicago Cubs. |
| 03/19/22 | LHP Bryan Hudson assigned to Chicago Cubs. |
| 03/19/22 | Chicago Cubs signed free agent RHP Adrian Sampson to a minor league contract and invited him to spring training. |
| 03/19/22 | Chicago Cubs activated LHP Drew Smyly. |
| 03/19/22 | 2B Bryce Windham roster status changed by Chicago Cubs. |
| 03/19/22 | RHP Adrian Sampson roster status changed by Chicago Cubs. |
| 03/18/22 | CF Narciso Crook roster status changed by Chicago Cubs. |
| 03/18/22 | LHP Locke St. John roster status changed by Chicago Cubs. |
| 03/18/22 | C Harrison Wenson roster status changed by Chicago Cubs. |
| 03/18/22 | RHP James Bourque roster status changed by Chicago Cubs. |
| 03/18/22 | Chicago Cubs placed RHP Adbert Alzolay on the 60-day injured list. |
| 03/18/22 | Chicago Cubs activated OF Seiya Suzuki. |
| 03/18/22 | C Harrison Wenson roster status changed by Chicago Cubs. |
| 03/18/22 | LHP Matt Dermody roster status changed by Chicago Cubs. |
| 03/18/22 | RHP Aneuris Rosario roster status changed by Chicago Cubs. |
| 03/18/22 | CF Narciso Crook assigned to Chicago Cubs. |
| 03/18/22 | RHP James Bourque assigned to Chicago Cubs. |
| 03/18/22 | LHP Matt Dermody assigned to Chicago Cubs. |
| 03/18/22 | LHP Locke St. John assigned to Chicago Cubs. |
| 03/18/22 | Chicago Cubs reassigned LF Alexander Canario to the minor leagues. |
| 03/18/22 | Chicago Cubs signed free agent OF Seiya Suzuki. |
| 03/18/22 | Chicago Cubs activated OF Seiya Suzuki. |
| 03/18/22 | 3B David Villar assigned to Chicago Cubs. |
| 03/18/22 | RHP Aneuris Rosario assigned to Chicago Cubs. |
| 03/18/22 | Chicago Cubs optioned SS Christopher Morel to Tennessee Smokies. |
| 03/18/22 | Chicago Cubs optioned RHP Alexander Vizcaino to Tennessee Smokies. |
| 03/18/22 | Chicago Cubs optioned LF Alexander Canario to South Bend Cubs. |
| 03/18/22 | Chicago Cubs optioned OF Nelson Velazquez to Iowa Cubs. |
| 03/17/22 | OF Owen Caissie assigned to Chicago Cubs. |
| 03/17/22 | RHP Eric Yardley and assigned to Chicago Cubs. |
| 03/17/22 | LHP Brandon Leibrandt assigned to Chicago Cubs. |
| 03/17/22 | C Miguel Fabrizio and assigned to Chicago Cubs. |
| 03/17/22 | RHP Ben Leeper and assigned to Chicago Cubs. |
| 03/17/22 | C Erick Castillo assigned to Chicago Cubs. |
| 03/17/22 | OF Brennen Davis assigned to Chicago Cubs. |
| 03/17/22 | OF Pete Crow-Armstrong assigned to Chicago Cubs. |
| 03/17/22 | RHP Jonathan Holder and assigned to Chicago Cubs. |
| 03/17/22 | CF Donnie Dewees assigned to Chicago Cubs. |
| 03/17/22 | 2B Andy Weber assigned to Chicago Cubs. |
| 03/17/22 | 2B Delvin Zinn assigned to Chicago Cubs. |
| 03/17/22 | RHP Yovanny Cabrera and assigned to Chicago Cubs. |
| 03/17/22 | CF Jacob Wetzel assigned to Chicago Cubs. |
| 03/17/22 | OF Jordan Nwogu assigned to Chicago Cubs. |
| 03/17/22 | SS Edwin Figuera assigned to Chicago Cubs. |
| 03/17/22 | RHP Manuel Espinoza and assigned to Chicago Cubs. |
| 03/17/22 | RHP Hunter Bigge and assigned to Chicago Cubs. |
| 03/17/22 | OF Nelson Maldonado assigned to Chicago Cubs. |
| 03/17/22 | 2B Christian Donahue assigned to Chicago Cubs. |
| 03/17/22 | LHP Eric Stout assigned to Chicago Cubs. |
| 03/17/22 | SS Kevin Made assigned to Chicago Cubs. |
| 03/17/22 | OF D.J. Artis roster status changed by Chicago Cubs. |
| 03/17/22 | C P.J. Higgins assigned to Chicago Cubs. |
| 03/17/22 | 2B Ildemaro Vargas assigned to Chicago Cubs. |
| 03/17/22 | 2B Andy Weber roster status changed by Chicago Cubs. |
| 03/17/22 | C Tyler Payne assigned to Chicago Cubs. |
| 03/17/22 | SS Miguel Pabon assigned to Chicago Cubs. |
| 03/17/22 | RHP Cayne Ueckert and assigned to Chicago Cubs. |
| 03/17/22 | 2B Trent Giambrone assigned to Chicago Cubs. |
| 03/17/22 | IF Grayson Byrd assigned to Chicago Cubs. |
| 03/17/22 | OF D.J. Artis assigned to Chicago Cubs. |
| 03/17/22 | OF Bradlee Beesley assigned to Chicago Cubs. |
| 03/17/22 | 2B Jared Young assigned to Chicago Cubs. |
| 03/17/22 | LHP Ben Holmes assigned to Chicago Cubs. |
| 03/17/22 | Chicago Cubs placed LHP Brad Wieck on the 60-day injured list. Left elbow strain. |
| 03/17/22 | SS Levi Jordan assigned to Chicago Cubs. |
| 03/17/22 | C Ethan Hearn assigned to Chicago Cubs. |
| 03/17/22 | RHP Daniel Palencia and assigned to Chicago Cubs. |
| 03/17/22 | RHP Mark Leiter Jr. and assigned to Chicago Cubs. |
| 03/17/22 | SS Josue Huma and assigned to Chicago Cubs. |
| 03/17/22 | RHP Bailey Reid and assigned to Chicago Cubs. |
| 03/17/22 | C John Hicks and assigned to Chicago Cubs. |
| 03/17/22 | 2B Chase Strumpf and assigned to Chicago Cubs. |
| 03/17/22 | OF Nelson Maldonado roster status changed by Chicago Cubs. |
| 03/17/22 | 1B Bryce Ball assigned to Chicago Cubs. |
| 03/17/22 | 2B Carlos Sepulveda assigned to Chicago Cubs. |
| 03/17/22 | 2B Ildemaro Vargas and assigned to Chicago Cubs. |
| 03/17/22 | 2B Dixon Machado and assigned to Chicago Cubs. |
| 03/17/22 | CF Zach Davis assigned to Chicago Cubs. |
| 03/17/22 | SS Ed Howard assigned to Chicago Cubs. |
| 03/17/22 | C Tim Susnara and assigned to Chicago Cubs. |
| 03/17/22 | LHP Conner Menez and assigned to Chicago Cubs. |
| 03/17/22 | OF Darius Hill assigned to Chicago Cubs. |
| 03/17/22 | C Pablo Aliendo assigned to Chicago Cubs. |
| 03/17/22 | LHP Jordan Wicks assigned to Chicago Cubs. |
| 03/17/22 | 2B Yonathan Perlaza assigned to Chicago Cubs. |
| 03/17/22 | RHP Jose Miguel Gonzalez and assigned to Chicago Cubs. |
| 03/17/22 | C Moises Ballesteros assigned to Chicago Cubs. |
| 03/17/22 | OF Christian Franklin assigned to Chicago Cubs. |
| 03/17/22 | SS Miguel Pabon roster status changed by Chicago Cubs. |
| 03/17/22 | OF Jordan Nwogu roster status changed by Chicago Cubs. |
| 03/17/22 | SS Kevin Made roster status changed by Chicago Cubs. |
| 03/17/22 | LHP Brandon Leibrandt roster status changed by Chicago Cubs. |
| 03/17/22 | CF Jacob Wetzel roster status changed by Chicago Cubs. |
| 03/17/22 | LHP Eric Stout roster status changed by Chicago Cubs. |
| 03/17/22 | 2B Carlos Sepulveda roster status changed by Chicago Cubs. |
| 03/17/22 | SS Levi Jordan roster status changed by Chicago Cubs. |
| 03/17/22 | LHP Ben Holmes roster status changed by Chicago Cubs. |
| 03/17/22 | SS Ed Howard roster status changed by Chicago Cubs. |
| 03/17/22 | OF Darius Hill roster status changed by Chicago Cubs. |
| 03/17/22 | C P.J. Higgins roster status changed by Chicago Cubs. |
| 03/17/22 | C Ethan Hearn roster status changed by Chicago Cubs. |
| 03/17/22 | LHP Stephen Gonsalves and assigned to Chicago Cubs. |
| 03/17/22 | 2B Christian Donahue roster status changed by Chicago Cubs. |
| 03/17/22 | CF Donnie Dewees roster status changed by Chicago Cubs. |
| 03/17/22 | OF Bradlee Beesley roster status changed by Chicago Cubs. |
| 03/17/22 | 2B Delvin Zinn roster status changed by Chicago Cubs. |
| 03/17/22 | 2B Jared Young roster status changed by Chicago Cubs. |
| 03/17/22 | 2B Yonathan Perlaza roster status changed by Chicago Cubs. |
| 03/17/22 | C Tyler Payne roster status changed by Chicago Cubs. |
| 03/17/22 | LHP Adam Laskey and assigned to Chicago Cubs. |
| 03/17/22 | 2B Trent Giambrone roster status changed by Chicago Cubs. |
| 03/17/22 | SS Edwin Figuera roster status changed by Chicago Cubs. |
| 03/17/22 | OF Christian Franklin roster status changed by Chicago Cubs. |
| 03/17/22 | CF Zach Davis roster status changed by Chicago Cubs. |
| 03/17/22 | OF Pete Crow-Armstrong roster status changed by Chicago Cubs. |
| 03/17/22 | OF Brennen Davis roster status changed by Chicago Cubs. |
| 03/17/22 | OF Owen Caissie roster status changed by Chicago Cubs. |
| 03/17/22 | C Erick Castillo roster status changed by Chicago Cubs. |
| 03/17/22 | IF Grayson Byrd roster status changed by Chicago Cubs. |
| 03/17/22 | C Moises Ballesteros roster status changed by Chicago Cubs. |
| 03/17/22 | 1B Bryce Ball roster status changed by Chicago Cubs. |
| 03/17/22 | C Pablo Aliendo roster status changed by Chicago Cubs. |
| 03/17/22 | Chicago Cubs signed free agent RHP Chris Martin, and. |
| 03/16/22 | Chicago Cubs activated RHP David Robertson. |
| 03/16/22 | Chicago Cubs signed free agent LHP Eric Stout to a minor league contract. |
| 03/16/22 | LHP Jordan Wicks roster status changed by Chicago Cubs. |
| 03/16/22 | Chicago Cubs signed free agent LHP Brandon Leibrandt to a minor league contract. |
| 03/16/22 | Chicago Cubs placed RHP Codi Heuer on the 60-day injured list. Recovery from Tommy John surgery. |
| 03/16/22 | Chicago Cubs activated RHP David Robertson. |
| 03/16/22 | Chicago Cubs signed free agent RHP David Robertson. |
| 03/15/22 | Chicago Cubs signed free agent SS Andrelton Simmons. |
| 03/15/22 | Chicago Cubs activated SS Andrelton Simmons. |
| 03/14/22 | Chicago Cubs invited non-roster RHP Jesse Chavez to spring training. |
| 03/14/22 | Chicago Cubs signed free agent RHP Jesse Chavez to a minor league contract. |