Padres Roster & Staff
Transactions
| Date | Transaction |
| 11/23/20 | San Diego Padres released RHP Luis Perdomo. |
| 11/20/20 | San Diego Padres selected the contract of SS Tucupita Marcano. |
| 11/20/20 | San Diego Padres designated RHP Luis Perdomo for assignment. |
| 11/20/20 | San Diego Padres selected the contract of RHP Mason Thompson from Lake Elsinore Storm. |
| 11/20/20 | San Diego Padres selected the contract of 2B Tucupita Marcano from Lake Elsinore Storm. |
| 11/20/20 | San Diego Padres selected the contract of RHP Reggie Lawson from Amarillo Sod Poodles. |
| 11/20/20 | San Diego Padres selected the contract of SS Tucupita Marcano. |
| 11/17/20 | San Diego Padres signed free agent 3B Nick Tanielu. |
| 11/17/20 | San Diego Padres signed free agent 3B Nick Tanielu to a minor league contract and invited him to spring training. |
| 11/17/20 | San Diego Padres signed free agent C Yohel Pozo to a minor league contract. |
| 11/17/20 | San Diego Padres signed free agent RHP Parker Markel to a minor league contract. |
| 11/17/20 | San Diego Padres signed free agent 3B Nick Tanielu to a minor league contract and invited him to spring training. |
| 11/17/20 | San Diego Padres signed free agent OF Jose Azocar to a minor league contract. |
| 11/16/20 | San Diego Padres signed free agent 2B Gosuke Katoh to a minor league contract and invited him to spring training. |
| 11/16/20 | San Diego Padres signed free agent 2B Gosuke Katoh. |
| 11/16/20 | San Diego Padres signed free agent 2B Gosuke Katoh to a minor league contract and invited him to spring training. |
| 11/09/20 | Cleveland Indians traded RHP Matt Waldron to San Diego Padres. |
| 11/08/20 | Cleveland Indians traded Matt Waldron to San Diego Padres. |
| 11/05/20 | San Diego Padres traded CF Junior Perez to Oakland Athletics. PTBNL in Jorge Mateo trade, 6/29/20 |
| 11/05/20 | San Diego Padres traded RHP Dylan Coleman to Kansas City Royals. |
| 11/02/20 | San Diego Padres activated LHP Jose Castillo from the 60-day injured list. |
| 11/02/20 | San Diego Padres activated RHP Trey Wingenter from the 60-day injured list. |
| 11/02/20 | San Diego Padres activated RHP Anderson Espinoza from the 60-day injured list. |
| 11/01/20 | 1B Mitch Moreland elected free agency. |