Padres Roster & Staff
Transactions
| Date | Transaction |
| 12/12/25 | San Diego Padres signed free agent RHP Nathanael Jacinto to a minor league contract. |
| 12/12/25 | San Diego Padres signed free agent RHP Albieris Polanco to a minor league contract. |
| 12/10/25 | Washington Nationals purchased contract of RHP Eiker Huizi in the Rule 5 Draft, AAA Phase. |
| 12/10/25 | Chicago Cubs purchased contract of 3B Devin Ortiz in the Rule 5 Draft, AAA Phase. |
| 12/08/25 | San Diego Padres signed free agent RHP Daison Acosta. |
| 12/08/25 | San Diego Padres signed free agent RHP Evan Fitterer to a minor league contract. |
| 12/04/25 | San Diego Padres signed free agent RHP Ty Adcock. |
| 12/04/25 | San Diego Padres signed free agent RHP Misael Tamarez to a minor league contract. |