Padres Roster & Staff
Transactions
| Date | Transaction |
| 12/15/21 | San Diego Padres signed free agent LHP Luke Westphal to a minor league contract. |
| 12/14/21 | San Diego Padres signed free agent SS Domingo Leyba to a minor league contract. |
| 12/14/21 | San Diego Padres signed free agent OF Oliver Carrillo to a minor league contract. |
| 12/10/21 | RHP Matthew Swilley roster status changed by San Diego Padres. |
| 12/10/21 | San Diego Padres signed free agent RHP Matthew Swilley to a minor league contract. |
| 12/01/21 | San Diego Padres signed free agent RHP Robert Suarez. |
| 12/01/21 | San Diego Padres activated RHP Robert Suarez. |
| 12/01/21 | San Diego Padres activated C Jorge Alfaro. |
| 12/01/21 | San Diego Padres signed free agent RHP Luis Garcia. |
| 12/01/21 | San Diego Padres activated RHP Robert Suarez. |
| 12/01/21 | San Diego Padres activated C Jorge Alfaro. |
| 12/01/21 | San Diego Padres activated C Jorge Alfaro. |
| 12/01/21 | Miami Marlins traded C Jorge Alfaro to San Diego Padres. |