Padres Roster & Staff
Transactions
| Date | Transaction |
| 09/30/25 | RHP Alek Jacob roster status changed by San Diego Padres. |
| 09/30/25 | RHP Sean Reynolds roster status changed by San Diego Padres. |
| 09/30/25 | LHP Yuki Matsui roster status changed by San Diego Padres. |
| 09/30/25 | LHP JP Sears roster status changed by San Diego Padres. |
| 09/30/25 | RHP Matt Waldron roster status changed by San Diego Padres. |
| 09/30/25 | C Elias Díaz roster status changed by San Diego Padres. |
| 09/30/25 | San Diego Padres transferred RHP Jason Adam from the 15-day injured list to the 60-day injured list. Left quadriceps injury. |
| 09/30/25 | LHP Kyle Hart roster status changed by San Diego Padres. |
| 09/30/25 | 3B Will Wagner roster status changed by San Diego Padres. |
| 09/30/25 | LHP Omar Cruz roster status changed by San Diego Padres. |
| 09/30/25 | RF Ramón Laureano roster status changed by San Diego Padres. |
| 09/30/25 | LF Tirso Ornelas roster status changed by San Diego Padres. |
| 09/30/25 | RHP Ron Marinaccio roster status changed by San Diego Padres. |
| 09/30/25 | LHP Nestor Cortes roster status changed by San Diego Padres. |
| 09/30/25 | RHP Bryan Hoeing roster status changed by San Diego Padres. |
| 09/30/25 | San Diego Padres selected the contract of C Martín Maldonado from ACL Padres. |
| 09/29/25 | San Diego Padres activated RF Ramón Laureano from the 10-day injured list. |
| 09/29/25 | San Diego Padres activated LHP Nestor Cortes from the 15-day injured list. |
| 09/29/25 | San Diego Padres recalled LF Tirso Ornelas from El Paso Chihuahuas. |
| 09/29/25 | San Diego Padres recalled RHP Bryan Hoeing from El Paso Chihuahuas. |
| 09/29/25 | San Diego Padres recalled LHP Omar Cruz from El Paso Chihuahuas. |
| 09/29/25 | San Diego Padres recalled LHP Kyle Hart from ACL Padres. |
| 09/29/25 | San Diego Padres recalled RHP Matt Waldron from El Paso Chihuahuas. |
| 09/29/25 | San Diego Padres recalled RHP Ron Marinaccio from ACL Padres. |
| 09/29/25 | San Diego Padres recalled RHP Alek Jacob from El Paso Chihuahuas. |
| 09/29/25 | San Diego Padres recalled C Luis Campusano from El Paso Chihuahuas. |
| 09/29/25 | San Diego Padres recalled RHP Sean Reynolds from El Paso Chihuahuas. |
| 09/28/25 | San Diego Padres recalled LHP JP Sears from El Paso Chihuahuas. |
| 09/28/25 | San Diego Padres optioned LHP Kyle Hart to ACL Padres. |
| 09/27/25 | San Diego Padres placed RF Ramón Laureano on the 10-day injured list retroactive to September 25, 2025. Right index finger fracture. |
| 09/27/25 | San Diego Padres recalled 3B Will Wagner from ACL Padres. |
| 09/24/25 | San Diego Padres activated RHP David Morgan from the 15-day injured list. |
| 09/24/25 | San Diego Padres optioned RHP Ron Marinaccio to ACL Padres. |
| 09/23/25 | San Diego Padres activated SS Xander Bogaerts from the 10-day injured list. |
| 09/23/25 | San Diego Padres optioned 3B Will Wagner to ACL Padres. |
| 09/17/25 | 3B Manny Machado changed number to 13. |
| 09/17/25 | RF Fernando Tatis Jr. changed number to 23. |
| 09/16/25 | 3B Manny Machado changed number to 21. |
| 09/16/25 | RF Fernando Tatis Jr. changed number to 21. |
| 09/13/25 | San Diego Padres optioned LHP JP Sears to El Paso Chihuahuas. |
| 09/13/25 | San Diego Padres recalled RHP Bradgley Rodriguez from El Paso Chihuahuas. |
| 09/12/25 | San Diego Padres placed RHP David Morgan on the 15-day injured list retroactive to September 9, 2025. Right shoulder inflammation. |
| 09/12/25 | San Diego Padres recalled LHP JP Sears from El Paso Chihuahuas. |
| 09/09/25 | San Diego Padres activated RHP Michael King from the 15-day injured list. |
| 09/09/25 | San Diego Padres optioned RHP Alek Jacob to El Paso Chihuahuas. |
| 09/06/25 | San Diego Padres recalled RHP Randy Vásquez from El Paso Chihuahuas. |
| 09/06/25 | San Diego Padres optioned RHP Sean Reynolds to El Paso Chihuahuas. |
| 09/05/25 | San Diego Padres signed free agent SS Gabriel Ollarves to a minor league contract. |
| 09/05/25 | San Diego Padres placed LHP Nestor Cortes on the 15-day injured list retroactive to September 4, 2025. Left biceps tendinitis. |
| 09/05/25 | San Diego Padres recalled RHP Ron Marinaccio from El Paso Chihuahuas. |
| 09/02/25 | San Diego Padres placed RHP Jason Adam on the 15-day injured list. Left quadriceps injury. |
| 09/02/25 | San Diego Padres recalled RHP Alek Jacob from El Paso Chihuahuas. |
| 09/01/25 | San Diego Padres activated CF Jackson Merrill from the 10-day injured list. |
| 09/01/25 | San Diego Padres recalled RHP Sean Reynolds from El Paso Chihuahuas. |