Astros Roster & Staff
Transactions
| Date | Transaction |
| 04/25/10 | Sammy Gervacio roster status changed by Houston Astros. |
| 04/25/10 | Houston Astros optioned Wilton Lopez to Round Rock Express. |
| 04/23/10 | Houston Astros sent RHP Yorman Bazardo outright to Round Rock Express. |
| 04/20/10 | Lance Berkman roster status changed by Houston Astros. |
| 04/20/10 | Houston Astros placed 3B Chris Johnson on the 15-day disabled list retroactive to April 18, 2010. Strained right intercostal muscle. |
| 04/19/10 | Houston Astros sent RHP Sammy Gervacio on a rehab assignment to Round Rock Express. |
| 04/12/10 | John Curtis assigned to Tri-City ValleyCats from Houston Astros. |
| 04/11/10 | Houston Astros signed free agent C John Curtis to a minor league contract. |
| 04/08/10 | Michael Garciaparra assigned to Round Rock Express from Houston Astros. |
| 04/08/10 | Houston Astros recalled Wilton Lopez from Round Rock Express. |
| 04/08/10 | Houston Astros placed RHP Sammy Gervacio on the 15-day disabled list. Right shoulder posterior cuff strain. |
| 04/07/10 | Freddy Parejo assigned to Lancaster JetHawks from Houston Astros. |
| 04/07/10 | David Cook assigned to Corpus Christi Hooks from Houston Astros. |
| 04/07/10 | 3B Rayner Contreras assigned to Lancaster JetHawks from Houston Astros. |
| 04/06/10 | T.J. Burton assigned to Corpus Christi Hooks from Houston Astros. |
| 04/04/10 | Gustavo Chacin assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | Gary Majewski assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | RHP Shane Loux assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | Kevin Cash assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | 2B Matt Kata assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | Drew Meyer assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | Casey Daigle assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | Josh Banks assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | 1B Chris Shelton assigned to Round Rock Express from Houston Astros. |
| 04/04/10 | Oswaldo Navarro assigned to Round Rock Express from Houston Astros. |
| 04/03/10 | Houston Astros selected the contract of LF Cory Sullivan from Round Rock Express. |
| 04/01/10 | 3B Jhon Florentino assigned to Houston Astros. |