Astros Roster & Staff
Transactions
| Date | Transaction |
| 12/16/11 | Houston Astros sent Brian Bixler outright to Oklahoma City RedHawks. |
| 12/14/11 | Houston Astros traded RHP Mark Melancon to Boston Red Sox for SS Jed Lowrie and RHP Kyle Weiland. |
| 12/14/11 | Houston Astros traded RHP Mark Melancon to Boston Red Sox for SS Jed Lowrie and RHP Kyle Weiland. |
| 12/14/11 | Houston Astros traded RHP Mark Melancon to Boston Red Sox for SS Jed Lowrie and RHP Kyle Weiland. |
| 12/14/11 | Houston Astros released RF Nick Stavinoha. |
| 12/14/11 | Houston Astros designated Brian Bixler for assignment. |
| 12/08/11 | Boston Red Sox Traded SS Marwin Gonzalez to Houston Astros and Oklahoma City RedHawks Traded RHP Marco Antonio Duarte to Pawtucket Red Sox. |
| 12/08/11 | Houston Astros claimed RHP Rhiner Cruz off waivers from Binghamton Mets. |
| 12/02/11 | Houston Astros signed free agent SS Diory Hernandez to a minor league contract and invited him to spring training. |