Astros Roster & Staff
Transactions
| Date | Transaction |
| 04/29/22 | Houston Astros sent 2B Jose Altuve on a rehab assignment to Sugar Land Space Cowboys. |
| 04/27/22 | Houston Astros released RHP Pedro Baez. |
| 04/26/22 | Houston Astros designated RHP Pedro Baez for assignment. |
| 04/26/22 | Houston Astros recalled RHP Seth Martinez from Sugar Land Space Cowboys. |
| 04/25/22 | Houston Astros signed free agent RHP Angelo Martinez to a minor league contract. |
| 04/22/22 | Houston Astros signed free agent RHP Enrique Coronel to a minor league contract. |
| 04/22/22 | Houston Astros signed free agent RHP Jose Guedez to a minor league contract. |
| 04/20/22 | Houston Astros placed 1B Taylor Jones on the 10-day injured list. Low back discomfort. |
| 04/20/22 | Houston Astros placed 2B Jose Altuve on the 10-day injured list retroactive to April 19, 2022. Left hamstring strain. |
| 04/20/22 | Houston Astros selected the contract of 1B J.J. Matijevic from Sugar Land Space Cowboys. |
| 04/18/22 | Houston Astros activated 1B Yordan Alvarez from the 10-day injured list. |
| 04/18/22 | Houston Astros transferred RHP Lance McCullers Jr. from the 10-day injured list to the 60-day injured list. Right forearm strain. |
| 04/18/22 | Houston Astros optioned 3B Joe Perez to Corpus Christi Hooks. |
| 04/16/22 | Houston Astros placed RHP Ryan Pressly on the 10-day injured list retroactive to April 14, 2022. Right knee inflammation. |
| 04/16/22 | Houston Astros selected the contract of LHP Parker Mushinski from Sugar Land Space Cowboys. |
| 04/15/22 | Houston Astros placed 1B Yordan Alvarez on the 10-day injured list. |
| 04/15/22 | Houston Astros recalled 3B Joe Perez from Corpus Christi Hooks. |
| 04/11/22 | Houston Astros activated 1B Yuli Gurriel from the paternity list. |
| 04/11/22 | Houston Astros optioned 3B Joe Perez to Corpus Christi Hooks. |
| 04/10/22 | Houston Astros signed free agent OF Roiner Quintana to a minor league contract. |
| 04/10/22 | Houston Astros sent RHP Tyler Ivey outright to Sugar Land Space Cowboys. |
| 04/09/22 | Houston Astros signed free agent RHP Dawill Almonte to a minor league contract. |
| 04/08/22 | Houston Astros placed 1B Yuli Gurriel on the paternity list. |
| 04/08/22 | Houston Astros recalled 3B Joe Perez from Corpus Christi Hooks. |
| 04/07/22 | Houston Astros designated RHP Tyler Ivey for assignment. |
| 04/07/22 | Houston Astros selected the contract of RHP Ronel Blanco, and from Sugar Land Space Cowboys. |
| 04/04/22 | Houston Astros placed RHP Lance McCullers Jr. on the 10-day injured list. Right forearm strain. |
| 04/04/22 | Houston Astros placed 1B Taylor Jones on the 10-day injured list. Low back discomfort. |
| 04/04/22 | Houston Astros placed CF Jake Meyers on the 10-day injured list. Left shoulder surgery. |
| 04/04/22 | RHP Gerardo Bojorquez and assigned to Houston Astros. |
| 04/03/22 | Houston Astros optioned RHP Seth Martinez to Sugar Land Space Cowboys. |
| 04/03/22 | Houston Astros optioned RHP Brandon Bielak to Sugar Land Space Cowboys. |
| 04/02/22 | RHP Tommy DeJuneas roster status changed by Houston Astros. |
| 04/02/22 | RHP Tommy DeJuneas assigned to Houston Astros. |
| 04/02/22 | 2B Alfredo Bohorquez assigned to Houston Astros. |
| 04/02/22 | RHP Kevin Holcomb roster status changed by Houston Astros. |
| 04/02/22 | RHP Kevin Holcomb assigned to Houston Astros. |
| 04/01/22 | RHP Jonathan Sprinkle and assigned to Houston Astros. |
| 04/01/22 | Houston Astros signed free agent RHP Geraldo Cabrera to a minor league contract. |