Padres Roster & Staff
Transactions
| Date | Transaction |
| 06/30/18 | San Diego Padres signed OF Grant Little. |
| 06/30/18 | San Diego Padres signed RHP Jose Quezada. |
| 06/29/18 | St. Louis Cardinals claimed LHP Tyler Webb off waivers from San Diego Padres. |
| 06/28/18 | San Diego Padres signed 1B Michael Suarez. |
| 06/25/18 | San Diego Padres signed free agent LHP Trent Shelton to a minor league contract. |
| 06/24/18 | San Diego Padres placed RHP Jordan Lyles on the 10-day disabled list retroactive to June 21, 2018. Right elbow inflammation. |
| 06/24/18 | San Diego Padres optioned RHP Phil Maton to El Paso Chihuahuas. |
| 06/24/18 | San Diego Padres recalled Kazuhisa Makita from El Paso Chihuahuas. |
| 06/24/18 | San Diego Padres optioned C Raffy Lopez to El Paso Chihuahuas. |
| 06/24/18 | San Diego Padres activated C Austin Hedges from the 10-day injured list. |
| 06/24/18 | San Diego Padres selected the contract of Robert Stock from El Paso Chihuahuas. |
| 06/24/18 | San Diego Padres designated LHP Tyler Webb for assignment. |
| 06/21/18 | San Diego Padres reassigned RHP Colin Rea to the minor leagues. |
| 06/21/18 | San Diego Padres optioned RHP Colin Rea to El Paso Chihuahuas. |
| 06/21/18 | Phil Maton roster status changed by San Diego Padres. |
| 06/21/18 | San Diego Padres transferred LF Franchy Cordero from the 10-day disabled list to the 60-day disabled list. Right forearm strain. |
| 06/21/18 | San Diego Padres activated LF Wil Myers. |
| 06/21/18 | San Diego Padres placed RHP Phil Hughes on the 10-day disabled list. Right rhomboid strain |
| 06/21/18 | San Diego Padres optioned RF Franmil Reyes to El Paso Chihuahuas. |
| 06/20/18 | San Diego Padres placed RHP Bryan Mitchell on the 10-day disabled list retroactive to June 17, 2018. Right elbow impingement. |
| 06/20/18 | Joey Lucchesi roster status changed by San Diego Padres. |
| 06/18/18 | San Diego Padres signed RHP Reiss Knehr. |
| 06/18/18 | San Diego Padres signed LHP Alexuan Vega. |
| 06/18/18 | San Diego Padres signed LHP Cody Tyler. |
| 06/18/18 | San Diego Padres signed SS Xavier Edwards. |
| 06/18/18 | San Diego Padres signed SS Jarryd Dale. |
| 06/18/18 | San Diego Padres signed C Nick Gatewood. |
| 06/18/18 | San Diego Padres signed OF Jawuan Harris. |
| 06/18/18 | San Diego Padres signed LHP Hazahel Quijada. |
| 06/18/18 | San Diego Padres signed LHP Erik Sabrowski. |
| 06/18/18 | San Diego Padres signed RHP Seth Mayberry. |
| 06/18/18 | San Diego Padres signed RHP Mason Fox. |
| 06/18/18 | San Diego Padres signed RHP Felix Minjarez. |
| 06/18/18 | San Diego Padres signed LHP Tyler Mortensen. |
| 06/18/18 | San Diego Padres signed 2B Lee Solomon. |
| 06/18/18 | San Diego Padres signed C Rainier Aguilar. |
| 06/18/18 | San Diego Padres signed OF Payton Smith. |
| 06/17/18 | San Diego Padres sent C Austin Hedges on a rehab assignment to El Paso Chihuahuas. |
| 06/14/18 | San Diego Padres signed SS Owen Miller. |
| 06/14/18 | San Diego Padres signed OF Michael Curry. |
| 06/14/18 | San Diego Padres signed OF Dwanya Williams-Sutton. |
| 06/14/18 | San Diego Padres signed 2B Luke Becker. |
| 06/14/18 | San Diego Padres sent LHP Joey Lucchesi on a rehab assignment to Lake Elsinore Storm. |
| 06/14/18 | San Diego Padres sent OF Franchy Cordero on a rehab assignment to El Paso Chihuahuas. |
| 06/14/18 | San Diego Padres signed RHP Steven Wilson. |
| 06/14/18 | San Diego Padres sent OF Wil Myers on a rehab assignment to El Paso Chihuahuas. |
| 06/14/18 | San Diego Padres signed RHP Gabe Mosser. |
| 06/14/18 | San Diego Padres signed RHP Dylan Coleman. |
| 06/12/18 | San Diego Padres sent C Austin Hedges on a rehab assignment to Lake Elsinore Storm. |
| 06/12/18 | San Diego Padres signed RHP Jake Sims. |
| 06/11/18 | San Diego Padres sent SS Allen Cordoba on a rehab assignment to Lake Elsinore Storm. |
| 06/08/18 | San Diego Padres sent RHP Phil Maton on a rehab assignment to San Antonio Missions. |
| 06/05/18 | San Diego Padres sent RHP Phil Maton on a rehab assignment to Lake Elsinore Storm. |
| 06/02/18 | San Diego Padres recalled LHP Jose Castillo from El Paso Chihuahuas. |
| 06/02/18 | San Diego Padres optioned RHP Walker Lockett to El Paso Chihuahuas. |
| 06/02/18 | San Diego Padres sent LHP Kyle McGrath outright to El Paso Chihuahuas. |
| 06/01/18 | San Diego Padres recalled Walker Lockett from El Paso Chihuahuas. |
| 06/01/18 | San Diego Padres optioned RHP Kazuhisa Makita to El Paso Chihuahuas. |