Padres Roster & Staff
Transactions
| Date | Transaction |
| 06/30/21 | San Diego Padres recalled RHP Miguel Diaz from El Paso Chihuahuas. |
| 06/30/21 | San Diego Padres placed LHP Blake Snell on the 10-day injured list. |
| 06/29/21 | San Diego Padres activated LHP Drew Pomeranz from the 10-day injured list. |
| 06/28/21 | San Diego Padres activated RHP Pierce Johnson from the 10-day injured list. |
| 06/28/21 | San Diego Padres optioned RHP Miguel Diaz to El Paso Chihuahuas. |
| 06/28/21 | San Diego Padres optioned RHP James Norwood to El Paso Chihuahuas. |
| 06/27/21 | San Diego Padres placed RHP Dinelson Lamet on the 10-day injured list. Right forearm inflammation. |
| 06/27/21 | San Diego Padres recalled RHP James Norwood from El Paso Chihuahuas. |
| 06/25/21 | San Diego Padres signed free agent RHP Alex Powers to a minor league contract. |
| 06/22/21 | San Diego Padres signed free agent RHP Octavio Castro to a minor league contract. |
| 06/20/21 | San Diego Padres optioned RHP James Norwood to El Paso Chihuahuas. |
| 06/20/21 | San Diego Padres recalled RHP Mason Thompson from El Paso Chihuahuas. |
| 06/20/21 | San Diego Padres recalled LHP Nick Ramirez from El Paso Chihuahuas. |
| 06/20/21 | San Diego Padres optioned LHP Daniel Camarena to El Paso Chihuahuas. |
| 06/19/21 | San Diego Padres sent RHP Sam McWilliams outright to El Paso Chihuahuas. |
| 06/19/21 | San Diego Padres selected the contract of LHP Daniel Camarena from El Paso Chihuahuas. |
| 06/19/21 | San Diego Padres placed RHP Pierce Johnson on the 10-day injured list. Right triceps inflammation. |
| 06/16/21 | San Diego Padres recalled RHP James Norwood from El Paso Chihuahuas. |
| 06/16/21 | San Diego Padres optioned LHP Ryan Weathers to El Paso Chihuahuas. |
| 06/13/21 | San Diego Padres signed free agent LHP Joe Beimel to a minor league contract. |
| 06/12/21 | San Diego Padres optioned CF Brian O'Grady to El Paso Chihuahuas. |
| 06/12/21 | San Diego Padres activated CF Trent Grisham. |
| 06/10/21 | San Diego Padres sent CF Trent Grisham on a rehab assignment to El Paso Chihuahuas. |
| 06/07/21 | San Diego Padres optioned SS Tucupita Marcano to El Paso Chihuahuas. |
| 06/07/21 | San Diego Padres recalled CF Brian O'Grady from El Paso Chihuahuas. |
| 06/06/21 | San Diego Padres signed free agent RHP Adrian De Los Santos to a minor league contract. |
| 06/05/21 | San Diego Padres placed RHP Taylor Williams on the 60-day injured list. |
| 06/05/21 | San Diego Padres claimed RHP Sam McWilliams off waivers from New York Mets. |