Padres Roster & Staff
Transactions
| Date | Transaction |
| 07/30/22 | San Diego Padres signed OF Jakob Marsee. |
| 07/30/22 | San Diego Padres signed free agent OF Braedon Karpathios. |
| 07/30/22 | San Diego Padres signed 3B Graham Pauley. |
| 07/30/22 | San Diego Padres signed free agent OF Kai Murphy to a minor league contract. |
| 07/30/22 | San Diego Padres signed free agent LHP Zimo Qin to a minor league contract. |
| 07/29/22 | San Diego Padres placed RHP Nick Martinez on the paternity list. |
| 07/29/22 | San Diego Padres sent RHP Robert Suarez on a rehab assignment to El Paso Chihuahuas. |
| 07/29/22 | San Diego Padres recalled RHP Michel Baez from El Paso Chihuahuas. |
| 07/28/22 | San Diego Padres signed C Romeo Sanabria. |
| 07/28/22 | San Diego Padres signed free agent OF Ramses Velazquez to a minor league contract. |
| 07/27/22 | San Diego Padres signed free agent C Jacob Campbell to a minor league contract. |
| 07/26/22 | San Diego Padres sent RHP Robert Suarez on a rehab assignment to ACL Padres. |
| 07/26/22 | San Diego Padres placed LHP MacKenzie Gore on the 15-day injured list. Let elbow inflammation. |
| 07/26/22 | San Diego Padres sent RHP Robert Suarez on a rehab assignment to ACL Padres. |
| 07/26/22 | San Diego Padres recalled RHP Dinelson Lamet from El Paso Chihuahuas. |
| 07/22/22 | San Diego Padres signed free agent OF Wyatt Ulrich to a minor league contract. |
| 07/22/22 | San Diego Padres sent 1B Wil Myers on a rehab assignment to El Paso Chihuahuas. |
| 07/15/22 | San Diego Padres activated RHP Steven Wilson. |
| 07/15/22 | San Diego Padres activated 3B Jurickson Profar. |
| 07/15/22 | San Diego Padres optioned CF Jose Azocar to El Paso Chihuahuas. |
| 07/15/22 | San Diego Padres optioned RHP Tayler Scott to El Paso Chihuahuas. |
| 07/14/22 | San Diego Padres sent 3B Jurickson Profar on a rehab assignment to Lake Elsinore Storm. |
| 07/13/22 | San Diego Padres activated LHP Adrian Morejon. |
| 07/13/22 | San Diego Padres optioned RHP Reiss Knehr to El Paso Chihuahuas. |
| 07/12/22 | San Diego Padres transferred RHP Robert Suarez from the 15-day injured list to the 60-day injured list. |
| 07/12/22 | San Diego Padres sent 1B Wil Myers on a rehab assignment to Lake Elsinore Storm. |
| 07/12/22 | San Diego Padres sent RHP Steven Wilson on a rehab assignment to El Paso Chihuahuas. |
| 07/12/22 | San Diego Padres optioned OF Brent Rooker to El Paso Chihuahuas. |
| 07/12/22 | San Diego Padres selected the contract of 2B Esteury Ruiz from El Paso Chihuahuas. |
| 07/11/22 | San Diego Padres recalled RHP Reiss Knehr from El Paso Chihuahuas. |
| 07/11/22 | San Diego Padres optioned RHP Dinelson Lamet to El Paso Chihuahuas. |
| 07/10/22 | San Diego Padres traded 2B Robinson Cano to Atlanta Braves for cash. |
| 07/09/22 | San Diego Padres placed RHP Craig Stammen on the 15-day injured list retroactive to July 6, 2022. Right Shoulder inflammation. |
| 07/09/22 | LHP Ben Krauth assigned to San Diego Padres. |
| 07/09/22 | San Diego Padres recalled RHP Dinelson Lamet from El Paso Chihuahuas. |
| 07/08/22 | San Diego Padres sent 1B Matt Beaty on a rehab assignment to El Paso Chihuahuas. |
| 07/08/22 | San Diego Padres placed 3B Jurickson Profar on the 7-day injured list. Concussion. |
| 07/08/22 | San Diego Padres recalled OF Brent Rooker from El Paso Chihuahuas. |
| 07/06/22 | San Diego Padres sent LHP Adrian Morejon on a rehab assignment to El Paso Chihuahuas. |
| 07/06/22 | San Diego Padres sent LHP Adrian Morejon on a rehab assignment to El Paso Chihuahuas. |
| 07/06/22 | San Diego Padres sent RHP Kyle Tyler outright to El Paso Chihuahuas. |
| 07/05/22 | Arizona Diamondbacks claimed SS Sergio Alcantara off waivers from San Diego Padres. |
| 07/04/22 | San Diego Padres sent 1B Matt Beaty on a rehab assignment to ACL Padres. |
| 07/03/22 | San Diego Padres designated RHP Kyle Tyler for assignment. |
| 07/03/22 | San Diego Padres selected the contract of RHP Tayler Scott from El Paso Chihuahuas. |
| 07/03/22 | San Diego Padres optioned LHP Ray Kerr to El Paso Chihuahuas. |
| 07/02/22 | San Diego Padres signed free agent RHP Jeison Sanchez to a minor league contract. |
| 07/02/22 | San Diego Padres signed free agent RHP Duncan Snider to a minor league contract. |
| 07/01/22 | RHP Jose Espada assigned to San Diego Padres. |