Padres Roster & Staff
Transactions
| Date | Transaction |
| 09/30/22 | San Diego Padres sent CF Luis Liberato outright to El Paso Chihuahuas. |
| 09/27/22 | San Diego Padres designated CF Luis Liberato for assignment. |
| 09/27/22 | San Diego Padres selected the contract of 3B Brandon Dixon from El Paso Chihuahuas. |
| 09/15/22 | San Diego Padres activated 2B Brandon Drury from the 7-day injured list. |
| 09/15/22 | San Diego Padres optioned 2B Eguy Rosario to El Paso Chihuahuas. |
| 09/14/22 | Philadelphia Phillies claimed RHP Tayler Scott off waivers from San Diego Padres. |
| 09/11/22 | San Diego Padres activated RHP Craig Stammen from the 60-day injured list. |
| 09/11/22 | San Diego Padres designated RHP Tayler Scott for assignment. |
| 09/11/22 | Baltimore Orioles claimed C Cam Gallagher off waivers from San Diego Padres. |
| 09/11/22 | San Diego Padres sent 1B Matt Beaty outright to El Paso Chihuahuas. |
| 09/11/22 | San Diego Padres optioned RHP Nabil Crismatt to El Paso Chihuahuas. |
| 09/10/22 | San Diego Padres activated 1B Austin Nola from the paternity list. |
| 09/10/22 | San Diego Padres designated 1B Matt Beaty for assignment. |
| 09/10/22 | San Diego Padres activated RHP Pierce Johnson from the 60-day injured list. |
| 09/10/22 | San Diego Padres optioned RHP Reiss Knehr to El Paso Chihuahuas. |
| 09/09/22 | San Diego Padres placed 1B Austin Nola on the paternity list. |
| 09/09/22 | San Diego Padres designated C Cam Gallagher for assignment. |
| 09/09/22 | San Diego Padres selected the contract of CF Luis Liberato from El Paso Chihuahuas. |
| 09/07/22 | San Diego Padres signed free agent IF Ismael Javier to a minor league contract. |
| 09/06/22 | San Diego Padres sent RHP Craig Stammen on a rehab assignment to El Paso Chihuahuas. |
| 09/05/22 | San Diego Padres activated C Jorge Alfaro from the 10-day injured list. |
| 09/05/22 | San Diego Padres placed 2B Brandon Drury on the 7-day injured list. Concussion. |
| 09/01/22 | San Diego Padres sent C Jorge Alfaro on a rehab assignment to El Paso Chihuahuas. |
| 09/01/22 | San Diego Padres recalled 1B Matt Beaty from El Paso Chihuahuas. |
| 09/01/22 | San Diego Padres recalled RHP Reiss Knehr from El Paso Chihuahuas. |