Padres Roster & Staff
Transactions
| Date | Transaction |
| 10/24/22 | San Diego Padres activated LHP Ryan Weathers. |
| 10/24/22 | San Diego Padres activated C Brett Sullivan. |
| 10/24/22 | San Diego Padres activated LHP Jay Groome. |
| 10/24/22 | San Diego Padres activated RHP Reiss Knehr. |
| 10/24/22 | San Diego Padres activated RHP Angel Felipe. |
| 10/24/22 | San Diego Padres activated 2B Eguy Rosario. |
| 10/24/22 | San Diego Padres activated LHP Ray Kerr. |
| 10/24/22 | San Diego Padres activated RHP Michel Baez. |
| 10/24/22 | San Diego Padres activated RHP Efrain Contreras. |
| 10/24/22 | San Diego Padres activated RHP Craig Stammen. |
| 10/24/22 | San Diego Padres activated SS Matthew Batten. |
| 10/24/22 | San Diego Padres activated RHP Angel Felipe. |
| 10/24/22 | San Diego Padres activated C Brett Sullivan. |
| 10/24/22 | San Diego Padres activated LHP Jose Castillo. |
| 10/24/22 | San Diego Padres activated 3B Brandon Dixon. |
| 10/24/22 | San Diego Padres activated RHP Nabil Crismatt. |
| 10/11/22 | San Diego Padres activated RHP Mike Clevinger. |
| 10/11/22 | San Diego Padres reassigned 3B Brandon Dixon to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned RHP Angel Felipe to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned LHP Ray Kerr to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned C Brett Sullivan to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned RHP Craig Stammen to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned RHP Mike Clevinger to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned RHP Nabil Crismatt to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned RHP Reiss Knehr to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned LHP Jose Castillo to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned RHP Michel Baez to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned RHP Efrain Contreras to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned 2B Eguy Rosario to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned LHP Jay Groome to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned LHP Ryan Weathers to the minor leagues. |
| 10/07/22 | San Diego Padres reassigned SS Matthew Batten to the minor leagues. |
| 10/06/22 | San Diego Padres activated RHP Mike Clevinger from the 15-day injured list. |
| 10/06/22 | San Diego Padres recalled 2B Eguy Rosario from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled LHP Ray Kerr from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled LHP Ryan Weathers from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled RHP Reiss Knehr from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled C Brett Sullivan from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled LHP Jose Castillo from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled RHP Angel Felipe from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled RHP Michel Baez from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled SS Matthew Batten from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled LHP Jay Groome from El Paso Chihuahuas. |
| 10/06/22 | San Diego Padres recalled RHP Efrain Contreras from Fort Wayne TinCaps. |
| 10/05/22 | San Diego Padres placed RHP Mike Clevinger on the 15-day injured list. Illness. |
| 10/05/22 | San Diego Padres recalled RHP Nabil Crismatt from El Paso Chihuahuas. |