Tigers Roster & Staff
Transactions
| Date | Transaction |
| 05/31/22 | Detroit Tigers placed RHP Casey Mize on the 60-day injured list. Right elbow sprain. |
| 05/31/22 | Detroit Tigers activated RHP Will Vest. |
| 05/31/22 | Detroit Tigers optioned RHP Drew Carlton to Toledo Mud Hens. |
| 05/31/22 | Detroit Tigers recalled LHP Joey Wentz from Toledo Mud Hens. |
| 05/30/22 | Detroit Tigers sent RHP Will Vest on a rehab assignment to Toledo Mud Hens. |
| 05/30/22 | Detroit Tigers placed LF Robbie Grossman on the 10-day injured list. Neck strain. |
| 05/30/22 | Detroit Tigers recalled 2B Kody Clemens and from Toledo Mud Hens. |
| 05/27/22 | Detroit Tigers signed free agent RHP Franklin Paulino to a minor league contract. |
| 05/22/22 | Detroit Tigers placed LHP Eduardo Rodriguez on the 15-day injured list retroactive to May 19, 2022. Left ribcage sprain. |
| 05/22/22 | Los Angeles Dodgers traded LHP Andrew Shaps to Detroit Tigers. |
| 05/22/22 | Detroit Tigers recalled RHP Elvin Rodriguez from Toledo Mud Hens. |
| 05/20/22 | Detroit Tigers signed free agent RHP Gregoris Chalas to a minor league contract. |
| 05/20/22 | Detroit Tigers placed RHP Will Vest on the 10-day injured list. |
| 05/20/22 | Detroit Tigers selected the contract of RHP Drew Carlton from Toledo Mud Hens. |
| 05/20/22 | Detroit Tigers claimed SS Brendon Davis off waivers from Los Angeles Angels. |
| 05/19/22 | Detroit Tigers signed free agent RHP Drew Hutchison to a minor league contract. |
| 05/19/22 | Detroit Tigers signed free agent RF Trayce Thompson to a minor league contract. |
| 05/16/22 | Detroit Tigers signed free agent RHP Andres Ramos to a minor league contract. |
| 05/16/22 | Detroit Tigers placed CF Victor Reyes on the 10-day injured list. Right quad strain. |
| 05/16/22 | Detroit Tigers placed LF Austin Meadows on the 10-day injured list. Vertigo. |
| 05/16/22 | Detroit Tigers recalled RHP Alex Faedo from Toledo Mud Hens. |
| 05/16/22 | Detroit Tigers recalled CF Daz Cameron from Toledo Mud Hens. |
| 05/15/22 | Detroit Tigers activated CF Victor Reyes. |
| 05/15/22 | Detroit Tigers placed RHP Michael Pineda on the 15-day injured list. Right middle finger fracture. |
| 05/13/22 | RHP Drew Hutchison elected free agency. |
| 05/13/22 | Detroit Tigers optioned LHP Sam Howard to Toledo Mud Hens. |
| 05/13/22 | Detroit Tigers claimed LHP Sam Howard off waivers from Pittsburgh Pirates. |
| 05/12/22 | Detroit Tigers optioned LHP Joey Wentz to Toledo Mud Hens. |
| 05/12/22 | Detroit Tigers recalled RHP Jason Foley, and from Toledo Mud Hens. |
| 05/11/22 | Detroit Tigers designated RHP Drew Hutchison for assignment. |
| 05/11/22 | RHP Alex Faedo returned to Toledo Mud Hens from Detroit Tigers. |
| 05/11/22 | Detroit Tigers recalled LHP Joey Wentz from Toledo Mud Hens. |
| 05/10/22 | Detroit Tigers recalled RHP Alex Faedo from Toledo Mud Hens. |
| 05/09/22 | Detroit Tigers activated RF Akil Baddoo from the 10-day injured list. |
| 05/09/22 | Detroit Tigers sent CF Victor Reyes on a rehab assignment to Toledo Mud Hens. |
| 05/09/22 | Detroit Tigers sent RHP Casey Mize on a rehab assignment to Toledo Mud Hens. |
| 05/09/22 | Detroit Tigers optioned RF Akil Baddoo to Toledo Mud Hens. |
| 05/09/22 | Detroit Tigers recalled RHP Rony Garcia from Toledo Mud Hens. |
| 05/08/22 | Detroit Tigers sent RHP Matt Manning on a rehab assignment to Toledo Mud Hens. |
| 05/08/22 | Arizona Diamondbacks traded C Manuel Garcia to Detroit Tigers. |
| 05/05/22 | Detroit Tigers optioned RHP Alex Faedo to Toledo Mud Hens. |
| 05/04/22 | Detroit Tigers signed free agent RHP Eliseo Mota to a minor league contract. |
| 05/04/22 | Detroit Tigers signed free agent RHP Eiker Huizi to a minor league contract. |
| 05/04/22 | Detroit Tigers signed free agent LHP Luis Camilo to a minor league contract. |
| 05/04/22 | Detroit Tigers signed free agent RHP Henry Montilla to a minor league contract. |
| 05/04/22 | Detroit Tigers sent C Dustin Garneau outright to Toledo Mud Hens. |
| 05/04/22 | Detroit Tigers recalled RHP Alex Faedo from Toledo Mud Hens. |
| 05/02/22 | Detroit Tigers designated C Dustin Garneau for assignment. |
| 05/02/22 | Detroit Tigers placed LHP Tyler Alexander on the 10-day injured list retroactive to April 30, 2022. Left elbow sprain. |