Astros Roster & Staff
Transactions
| Date | Transaction |
| 03/30/22 | Houston Astros optioned RHP Josh James to Sugar Land Space Cowboys. |
| 03/28/22 | Houston Astros signed free agent RHP Carlos Mateo to a minor league contract. |
| 03/28/22 | Houston Astros optioned RHP Enoli Paredes to Sugar Land Space Cowboys. |
| 03/28/22 | Houston Astros optioned RHP Peter Solomon to Sugar Land Space Cowboys. |
| 03/27/22 | Houston Astros optioned RHP Forrest Whitley to Sugar Land Space Cowboys. |
| 03/27/22 | Houston Astros traded OF Norel Gonzalez and to Miami Marlins. |
| 03/25/22 | Houston Astros optioned 3B Joe Perez to Sugar Land Space Cowboys. |
| 03/24/22 | OF Joey Loperfido and assigned to Houston Astros. |
| 03/24/22 | Houston Astros signed free agent 2B Franklin Barreto and to a minor league contract and invited him to spring training. |
| 03/24/22 | C Colton Shaver assigned to Houston Astros. |
| 03/24/22 | Houston Astros optioned LHP Jonathan Bermudez to Sugar Land Space Cowboys. |
| 03/24/22 | Houston Astros optioned RHP Shawn Dubin to Sugar Land Space Cowboys. |
| 03/24/22 | Houston Astros optioned RHP Tyler Ivey to Sugar Land Space Cowboys. |
| 03/23/22 | RHP Michael Horrell roster status changed by Houston Astros. |
| 03/23/22 | RHP Michael Horrell assigned to Houston Astros. |
| 03/23/22 | RHP Devin Conn assigned to Houston Astros. |
| 03/23/22 | RHP Devin Conn roster status changed by Houston Astros. |
| 03/22/22 | Houston Astros signed free agent LHP Adam Morgan and to a minor league contract and invited him to spring training. |
| 03/22/22 | Houston Astros activated RHP Forrest Whitley. |
| 03/22/22 | CF Luis Guerrero and assigned to Houston Astros. |
| 03/22/22 | OF Cody Orr and assigned to Houston Astros. |
| 03/22/22 | C Freddy Guilamo and assigned to Houston Astros. |
| 03/21/22 | Houston Astros signed free agent RHP Euris Vasquez to a minor league contract. |
| 03/21/22 | Houston Astros signed free agent LHP Liz Sanchez to a minor league contract. |
| 03/20/22 | C Alex Holderbach assigned to Houston Astros. |
| 03/20/22 | SS Dauri Lorenzo assigned to Houston Astros. |
| 03/20/22 | RHP Brett Conine and assigned to Houston Astros. |
| 03/20/22 | RHP Franny Cobos roster status changed by Houston Astros. |
| 03/20/22 | CF Jordan Brewer roster status changed by Houston Astros. |
| 03/20/22 | OF Roilan Machandy assigned to Houston Astros. |
| 03/20/22 | OF Ross Adolph assigned to Houston Astros. |
| 03/20/22 | RHP Jose Betances and assigned to Houston Astros. |
| 03/20/22 | SS AJ Lee and assigned to Houston Astros. |
| 03/20/22 | SS J.C. Correa and assigned to Houston Astros. |
| 03/20/22 | CF Jordan Brewer assigned to Houston Astros. |
| 03/20/22 | OF Quincy Hamilton and assigned to Houston Astros. |
| 03/20/22 | OF Frank Perez and assigned to Houston Astros. |
| 03/20/22 | RHP Chad Donato and assigned to Houston Astros. |
| 03/20/22 | C Nathan Perry assigned to Houston Astros. |
| 03/20/22 | RHP Matt Ruppenthal roster status changed by Houston Astros. |
| 03/20/22 | OF Ross Adolph roster status changed by Houston Astros. |
| 03/20/22 | RHP Franny Cobos assigned to Houston Astros. |
| 03/20/22 | RHP Ronny Garcia assigned to Houston Astros. |
| 03/20/22 | RHP Jairo Solis and assigned to Houston Astros. |
| 03/20/22 | OF Roilan Machandy roster status changed by Houston Astros. |
| 03/20/22 | SS Dauri Lorenzo roster status changed by Houston Astros. |
| 03/20/22 | RHP Ronny Garcia roster status changed by Houston Astros. |
| 03/20/22 | RHP Matt Ruppenthal assigned to Houston Astros. |
| 03/20/22 | LHP Hunter Peck and assigned to Houston Astros. |
| 03/19/22 | RHP Joe Record assigned to Houston Astros. |
| 03/19/22 | OF Wilyer Abreu and assigned to Houston Astros. |
| 03/19/22 | C Juan Santander assigned to Houston Astros. |
| 03/19/22 | 1B Peter Zimmermann assigned to Houston Astros. |
| 03/19/22 | 2B Bryan Arias roster status changed by Houston Astros. |
| 03/19/22 | C Juan Santander roster status changed by Houston Astros. |
| 03/19/22 | LHP Zac Rosscup roster status changed by Houston Astros. |
| 03/19/22 | C Nerio Rodriguez roster status changed by Houston Astros. |
| 03/19/22 | RHP Joe Record roster status changed by Houston Astros. |
| 03/19/22 | C Nerio Rodriguez assigned to Houston Astros. |
| 03/19/22 | OF Rainier Rivas and assigned to Houston Astros. |
| 03/19/22 | RHP Nick Hernandez roster status changed by Houston Astros. |
| 03/19/22 | SS Yeuris Ramirez and assigned to Houston Astros. |
| 03/19/22 | RHP Nick Hernandez assigned to Houston Astros. |
| 03/19/22 | OF Tyler Whitaker and assigned to Houston Astros. |
| 03/19/22 | SS Chad Stevens roster status changed by Houston Astros. |
| 03/19/22 | Houston Astros signed free agent LHP Zac Rosscup to a minor league contract. |
| 03/19/22 | 3B Justin Williams assigned to Houston Astros. |
| 03/19/22 | OF Norel Gonzalez assigned to Houston Astros. |
| 03/19/22 | RHP Jose Bravo and assigned to Houston Astros. |
| 03/19/22 | SS Chad Stevens assigned to Houston Astros. |
| 03/19/22 | IF Leosdany Molina roster status changed by Houston Astros. |
| 03/19/22 | 3B Justin Williams roster status changed by Houston Astros. |
| 03/19/22 | RHP Jimmy Endersby and assigned to Houston Astros. |
| 03/19/22 | C Luke Berryhill and assigned to Houston Astros. |
| 03/19/22 | OF Kenedy Corona and assigned to Houston Astros. |
| 03/19/22 | IF Leosdany Molina assigned to Houston Astros. |
| 03/19/22 | SS Yohander Martinez and assigned to Houston Astros. |
| 03/19/22 | 2B Bryan Arias assigned to Houston Astros. |
| 03/18/22 | CF Colin Barber assigned to Houston Astros. |
| 03/18/22 | C Miguel Palma assigned to Houston Astros. |
| 03/18/22 | RF Richi Gonzalez roster status changed by Houston Astros. |
| 03/18/22 | 2B Luis Santana assigned to Houston Astros. |
| 03/18/22 | LF Ramiro Rodriguez assigned to Houston Astros. |
| 03/18/22 | SS Hector Nieves and assigned to Houston Astros. |
| 03/18/22 | 2B Enmanuel Valdez and assigned to Houston Astros. |
| 03/18/22 | CF Colin Barber roster status changed by Houston Astros. |
| 03/18/22 | OF Logan Cerny and assigned to Houston Astros. |
| 03/18/22 | RF Richi Gonzalez assigned to Houston Astros. |
| 03/18/22 | SS Rolando Espinosa assigned to Houston Astros. |
| 03/18/22 | RF Justin Dirden roster status changed by Houston Astros. |
| 03/18/22 | 2B Luis Santana roster status changed by Houston Astros. |
| 03/18/22 | SS Cristian Gonzalez roster status changed by Houston Astros. |
| 03/18/22 | RHP Layne Henderson and assigned to Houston Astros. |
| 03/18/22 | C Miguel Palma roster status changed by Houston Astros. |
| 03/18/22 | SS Rolando Espinosa roster status changed by Houston Astros. |
| 03/18/22 | OF Zach Daniels assigned to Houston Astros. |
| 03/18/22 | SS Cristian Gonzalez assigned to Houston Astros. |
| 03/18/22 | RF Justin Dirden assigned to Houston Astros. |
| 03/18/22 | OF Michael Sandle and assigned to Houston Astros. |
| 03/18/22 | OF Zach Daniels roster status changed by Houston Astros. |
| 03/18/22 | LHP Kit Scheetz assigned to Houston Astros. |
| 03/18/22 | Houston Astros sent RHP Jairo Solis outright to Sugar Land Space Cowboys. |
| 03/15/22 | Houston Astros signed free agent 1B Niko Goodrum. |
| 03/15/22 | Houston Astros designated RHP Jairo Solis for assignment. |
| 03/13/22 | CF Lewis Brinson roster status changed by Houston Astros. |
| 03/13/22 | Houston Astros signed free agent CF Lewis Brinson to a minor league contract and invited him to spring training. |
| 03/12/22 | Houston Astros invited non-roster OF Alex McKenna and to spring training. |
| 03/12/22 | Houston Astros invited non-roster C Scott Manea and to spring training. |
| 03/12/22 | Houston Astros signed free agent RHP Justin Verlander, and. |
| 03/12/22 | Houston Astros invited non-roster OF Scott Schreiber and to spring training. |
| 03/12/22 | Houston Astros invited non-roster C Michael Papierski and to spring training. |
| 03/12/22 | Houston Astros invited non-roster C Cesar Salazar and to spring training. |
| 03/12/22 | Houston Astros invited non-roster RHP Jon Olczak and to spring training. |
| 03/12/22 | Houston Astros invited non-roster LHP Parker Mushinski and to spring training. |
| 03/12/22 | Houston Astros invited non-roster 1B J.J. Matijevic and to spring training. |
| 03/12/22 | Houston Astros invited non-roster SS Pedro Leon and to spring training. |
| 03/12/22 | Houston Astros invited non-roster C Korey Lee and to spring training. |
| 03/12/22 | Houston Astros invited non-roster SS Grae Kessinger and to spring training. |
| 03/12/22 | Houston Astros invited non-roster CF Corey Julks and to spring training. |
| 03/12/22 | Houston Astros invited non-roster SS David Hensley and to spring training. |
| 03/12/22 | Houston Astros invited non-roster SS Alex De Goti and to spring training. |
| 03/12/22 | Houston Astros invited non-roster OF Marty Costes and to spring training. |
| 03/12/22 | Houston Astros invited non-roster RHP Hunter Brown and to spring training. |
| 03/12/22 | Houston Astros invited non-roster RHP Ronel Blanco and to spring training. |
| 03/12/22 | Houston Astros invited non-roster RHP J.P. France and to spring training. |
| 03/03/22 | Houston Astros signed free agent RHP Yeriel Santos to a minor league contract. |