Astros Roster & Staff
Transactions
| Date | Transaction |
| 08/31/22 | Houston Astros traded CF Lewis Brinson to San Francisco Giants. |
| 08/30/22 | Houston Astros sent RHP Josh James on a rehab assignment to Sugar Land Space Cowboys. |
| 08/30/22 | Houston Astros placed RHP Justin Verlander on the 15-day injured list retroactive to August 29, 2022. Right calf injury. |
| 08/30/22 | Houston Astros recalled 1B J.J. Matijevic from Sugar Land Space Cowboys. |
| 08/30/22 | Houston Astros recalled RHP Brandon Bielak from Sugar Land Space Cowboys. |
| 08/29/22 | Houston Astros activated CF Jake Meyers from the 60-day injured list. |
| 08/29/22 | Houston Astros optioned CF Jake Meyers to Sugar Land Space Cowboys. |
| 08/25/22 | Houston Astros placed RHP Ryan Pressly on the 15-day injured list retroactive to August 22, 2022. Neck spasms. |
| 08/25/22 | Houston Astros sent RHP Josh James on a rehab assignment to Fayetteville Woodpeckers. |
| 08/25/22 | Houston Astros recalled RHP Seth Martinez from Sugar Land Space Cowboys. |
| 08/23/22 | San Francisco Giants claimed LHP Jonathan Bermudez off waivers from Houston Astros. |
| 08/20/22 | Houston Astros designated LHP Jonathan Bermudez for assignment. |
| 08/20/22 | Houston Astros optioned 1B J.J. Matijevic to Sugar Land Space Cowboys. |
| 08/20/22 | Houston Astros selected the contract of SS David Hensley, , , , , and from Sugar Land Space Cowboys. |
| 08/17/22 | Houston Astros placed SS Aledmys Diaz on the 10-day injured list. Left groin discomfort. |
| 08/17/22 | Houston Astros recalled 1B J.J. Matijevic from Sugar Land Space Cowboys. |
| 08/16/22 | Houston Astros sent LHP Blake Taylor on a rehab assignment to Sugar Land Space Cowboys. |
| 08/13/22 | Houston Astros transferred LF Michael Brantley from the 10-day injured list to the 60-day injured list. Recovering from Right Shoulder Surgery. |
| 08/13/22 | Houston Astros transferred LF Michael Brantley from the 10-day injured list to the 60-day injured list. |
| 08/13/22 | Houston Astros activated RHP Lance McCullers Jr. from the 60-day injured list. |
| 08/13/22 | Houston Astros optioned RHP Seth Martinez to Sugar Land Space Cowboys. |
| 08/11/22 | Houston Astros sent LHP Blake Taylor on a rehab assignment to FCL Astros Blue. |
| 08/03/22 | Houston Astros signed free agent C Jancel Villarroel to a minor league contract. |
| 08/02/22 | Houston Astros activated LF Trey Mancini. |
| 08/02/22 | Houston Astros activated C Christian Vazquez. |
| 08/02/22 | Houston Astros transferred C Jason Castro from the 10-day injured list to the 60-day injured list. Left knee discomfort. |
| 08/02/22 | Houston Astros activated 3B Alex Bregman from the paternity list. |
| 08/02/22 | Houston Astros optioned C Korey Lee to Sugar Land Space Cowboys. |
| 08/02/22 | Atlanta Braves traded LHP Will Smith to Houston Astros for RHP Jake Odorizzi. |
| 08/02/22 | Houston Astros optioned 1B Taylor Jones to Sugar Land Space Cowboys. |
| 08/02/22 | Houston Astros optioned 1B J.J. Matijevic to Sugar Land Space Cowboys. |
| 08/02/22 | Atlanta Braves traded LHP Will Smith to Houston Astros for RHP Jake Odorizzi. |
| 08/01/22 | Houston Astros placed 3B Alex Bregman on the paternity list. |
| 08/01/22 | Boston Red Sox traded C Christian Vazquez to Houston Astros for 2B Enmanuel Valdez and OF Wilyer Abreu. |
| 08/01/22 | Houston Astros traded RHP Chayce McDermott to Baltimore Orioles. |
| 08/01/22 | Houston Astros recalled 1B Taylor Jones from Sugar Land Space Cowboys. |
| 08/01/22 | Boston Red Sox traded C Christian Vazquez to Houston Astros for 2B Enmanuel Valdez and OF Wilyer Abreu. |
| 08/01/22 | Tampa Bay Rays traded RHP Jayden Murray to Houston Astros. |
| 08/01/22 | Boston Red Sox traded C Christian Vazquez to Houston Astros for 2B Enmanuel Valdez and OF Wilyer Abreu. |
| 08/01/22 | Houston Astros traded CF Jose Siri to Tampa Bay Rays. |
| 08/01/22 | Baltimore Orioles traded LF Trey Mancini to Houston Astros. |