Cardinals Roster & Staff
Cardinals
| Date | Transaction |
| 09/25/21 | St. Louis Cardinals recalled RHP Jake Woodford from Memphis Redbirds. |
| 09/25/21 | St. Louis Cardinals sent RHP Jordan Hicks on a rehab assignment to Memphis Redbirds. |
| 09/25/21 | St. Louis Cardinals placed RHP Justin Miller on the 10-day injured list. Right elbow strain. |
| 09/24/21 | St. Louis Cardinals activated RHP Jack Flaherty from the 10-day injured list. |
| 09/24/21 | St. Louis Cardinals activated RHP Dakota Hudson. |
| 09/24/21 | St. Louis Cardinals optioned LHP Brandon Waddell to Memphis Redbirds. |
| 09/24/21 | St. Louis Cardinals optioned RHP Jake Woodford to Memphis Redbirds. |
| 09/22/21 | St. Louis Cardinals sent RHP Daniel Ponce de Leon outright to Memphis Redbirds. |
| 09/20/21 | St. Louis Cardinals designated RHP Daniel Ponce de Leon for assignment. |
| 09/20/21 | St. Louis Cardinals recalled LHP Brandon Waddell from Memphis Redbirds. |
| 09/13/21 | St. Louis Cardinals sent RHP Dakota Hudson on a rehab assignment to Memphis Redbirds. |
| 09/12/21 | St. Louis Cardinals placed RHP Junior Fernandez on the 60-day injured list. |
| 09/11/21 | St. Louis Cardinals optioned C Ali Sanchez to Memphis Redbirds. |
| 09/11/21 | St. Louis Cardinals activated RHP Justin Miller. |
| 09/08/21 | St. Louis Cardinals sent RHP Brandon Dickson outright to Memphis Redbirds. |
| 09/07/21 | St. Louis Cardinals sent RHP Justin Miller on a rehab assignment to Memphis Redbirds. |
| 09/06/21 | St. Louis Cardinals activated LHP Andrew Miller from the 10-day injured list. |
| 09/06/21 | St. Louis Cardinals designated RHP Brandon Dickson for assignment. |
| 09/03/21 | St. Louis Cardinals placed RHP Junior Fernandez on the 10-day injured list. |
| 09/03/21 | St. Louis Cardinals recalled RHP Jake Woodford from Memphis Redbirds. |
| 09/02/21 | St. Louis Cardinals sent RHP Dakota Hudson on a rehab assignment to Springfield Cardinals. |
| 09/01/21 | St. Louis Cardinals selected the contract of RHP Brandon Dickson from Memphis Redbirds. |
| 09/01/21 | St. Louis Cardinals recalled C Ali Sanchez from Memphis Redbirds. |
| 09/01/21 | St. Louis Cardinals placed RHP Ryan Helsley on the 60-day injured list. Right elbow stress reaction. |
