Padres Roster & Staff
Transactions
| Date | Transaction |
| 03/27/25 | San Diego Padres placed RHP Matt Waldron on the 15-day injured list retroactive to March 24, 2025. Left oblique muscle strain. |
| 03/27/25 | San Diego Padres placed RHP Jhony Brito on the 15-day injured list retroactive to March 24, 2025. Right forearm strain. |
| 03/27/25 | San Diego Padres designated 3B Tyler Wade for assignment. |
| 03/27/25 | San Diego Padres designated 3B Eguy Rosario for assignment. |
| 03/27/25 | San Diego Padres placed RHP Yu Darvish on the 15-day injured list retroactive to March 24, 2025. Right elbow inflammation. |
| 03/27/25 | San Diego Padres placed RHP Bryan Hoeing on the 15-day injured list retroactive to March 24, 2025. Right shoulder strain. |
| 03/27/25 | San Diego Padres placed RHP Sean Reynolds on the 15-day injured list retroactive to March 24, 2025. Right foot stress reaction. |
| 03/27/25 | San Diego Padres selected the contract of 1B Yuli Gurriel from El Paso Chihuahuas. |
| 03/27/25 | San Diego Padres selected the contract of C Martín Maldonado from El Paso Chihuahuas. |
| 03/27/25 | San Diego Padres selected the contract of 2B Jose Iglesias from El Paso Chihuahuas. |
| 03/27/25 | San Diego Padres recalled LHP Omar Cruz from El Paso Chihuahuas. |
| 03/26/25 | San Diego Padres sent C Brett Sullivan outright to El Paso Chihuahuas. |
| 03/25/25 | San Diego Padres optioned 1B Connor Joe to El Paso Chihuahuas. |
| 03/25/25 | San Diego Padres optioned RHP Ron Marinaccio to El Paso Chihuahuas. |
| 03/25/25 | RHP Juan Nuñez returned to Baltimore Orioles from San Diego Padres. |
| 03/25/25 | San Diego Padres optioned RHP Stephen Kolek to El Paso Chihuahuas. |
| 03/23/25 | San Diego Padres released RHP Efrain Contreras. |
| 03/23/25 | San Diego Padres released CF Cole Roederer. |
| 03/23/25 | San Diego Padres released C Colton Bender. |
| 03/23/25 | 3B Devin Ortiz assigned to San Diego Padres. |
| 03/23/25 | San Diego Padres optioned LF Tirso Ornelas to El Paso Chihuahuas. |
| 03/23/25 | San Diego Padres optioned C Luis Campusano to El Paso Chihuahuas. |
| 03/22/25 | San Diego Padres designated C Brett Sullivan for assignment. |
| 03/22/25 | LHP Yovannki Pascual assigned to San Diego Padres. |
| 03/22/25 | San Diego Padres optioned SS Mason McCoy to El Paso Chihuahuas. |
| 03/22/25 | San Diego Padres selected the contract of SS Mason McCoy from El Paso Chihuahuas. |
| 03/21/25 | San Diego Padres activated OF Gavin Sheets. |
| 03/21/25 | San Diego Padres selected the contract of 1B Gavin Sheets from El Paso Chihuahuas. |
| 03/20/25 | OF Jacob Campbell assigned to San Diego Padres. |
| 03/20/25 | San Diego Padres placed RHP Joe Musgrove on the 60-day injured list. |
| 03/17/25 | LHP Igor Gil assigned to San Diego Padres. |
| 03/17/25 | RHP Vicarte Domingo assigned to San Diego Padres. |
| 03/17/25 | C Carlos Rodriguez assigned to San Diego Padres. |
| 03/17/25 | 2B Wyatt Hoffman assigned to San Diego Padres. |
| 03/16/25 | LHP Braian Salazar assigned to San Diego Padres. |
| 03/16/25 | RHP Jimmy Reyes assigned to San Diego Padres. |
| 03/16/25 | OF Moisés Gómez assigned to San Diego Padres. |
| 03/15/25 | LHP Ruben Salinas assigned to San Diego Padres. |
| 03/14/25 | San Diego Padres signed free agent RHP Miguel Angel Ledesma to a minor league contract. |
| 03/13/25 | San Diego Padres optioned LHP Tom Cosgrove to El Paso Chihuahuas. |
| 03/13/25 | San Diego Padres optioned LHP Omar Cruz to El Paso Chihuahuas. |
| 03/11/25 | LHP Luis Gutierrez assigned to San Diego Padres. |
| 03/11/25 | RHP Johan Moreno assigned to San Diego Padres. |
| 03/11/25 | RHP Maikel Miralles assigned to San Diego Padres. |
| 03/10/25 | San Diego Padres signed free agent RHP Andrew Bellatti to a minor league contract. |
| 03/10/25 | C Alcides Hernandez assigned to San Diego Padres. |
| 03/09/25 | RHP Carson Swilling assigned to San Diego Padres. |
| 03/09/25 | San Diego Padres optioned RHP Ryan Bergert to El Paso Chihuahuas. |
| 03/08/25 | C Kaden Hollow assigned to San Diego Padres. |
| 03/08/25 | 2B Jose Iglesias assigned to San Diego Padres. |
| 03/07/25 | RHP Jared Kollar assigned to San Diego Padres. |
| 03/07/25 | 2B Ripken Reyes assigned to San Diego Padres. |
| 03/07/25 | San Diego Padres optioned RHP Henry Baez to El Paso Chihuahuas. |
| 03/06/25 | C Oswaldo Linares assigned to San Diego Padres. |
| 03/06/25 | RHP Kleiber Olmedo assigned to San Diego Padres. |
| 03/06/25 | 2B Chase Valentine assigned to San Diego Padres. |
| 03/06/25 | RHP Miguel Valdez assigned to San Diego Padres. |
| 03/05/25 | C Yoiber Ocopio assigned to San Diego Padres. |
| 03/05/25 | RHP Eric Yost assigned to San Diego Padres. |
| 03/05/25 | LHP Wes Benjamin assigned to San Diego Padres. |
| 03/04/25 | RHP Bernard Jose assigned to San Diego Padres. |
| 03/04/25 | LHP Jackson Wolf assigned to San Diego Padres. |
| 03/04/25 | RHP Alejandro Lugo assigned to San Diego Padres. |
| 03/04/25 | C Addison Kopack assigned to San Diego Padres. |
| 03/04/25 | 2B Marcos Castañon assigned to San Diego Padres. |
| 03/04/25 | C Cody Roberts assigned to San Diego Padres. |
| 03/04/25 | 2B Marcos Castañon roster status changed by San Diego Padres. |
| 03/04/25 | C Brendan Durfee assigned to San Diego Padres. |
| 03/02/25 | RHP Jose Luis Reyes assigned to San Diego Padres. |
| 03/02/25 | RHP Josh Mallitz assigned to San Diego Padres. |
| 03/02/25 | LHP Harry Gustin assigned to San Diego Padres. |
| 03/01/25 | RHP Tyler Morgan assigned to San Diego Padres. |
| 03/01/25 | C Colton Vincent assigned to San Diego Padres. |