Padres Roster & Staff
Transactions
| Date | Transaction |
| 05/30/25 | San Diego Padres optioned LHP Kyle Hart to El Paso Chihuahuas. |
| 05/30/25 | San Diego Padres selected the contract of RHP Bradgley Rodriguez from San Antonio Missions. |
| 05/28/25 | San Diego Padres sent RHP Matt Waldron on a rehab assignment to El Paso Chihuahuas. |
| 05/28/25 | San Diego Padres sent RHP Matt Waldron on a rehab assignment to El Paso Chihuahuas. |
| 05/28/25 | San Diego Padres optioned LHP Omar Cruz to El Paso Chihuahuas. |
| 05/28/25 | San Diego Padres recalled LHP Kyle Hart from El Paso Chihuahuas. |
| 05/27/25 | San Diego Padres sent RHP Bryan Hoeing on a rehab assignment to El Paso Chihuahuas. |
| 05/27/25 | San Diego Padres sent RHP Bryan Hoeing on a rehab assignment to El Paso Chihuahuas. |
| 05/25/25 | San Diego Padres placed RHP Michael King on the 15-day injured list retroactive to May 22, 2025. Right shoulder inflammation. |
| 05/25/25 | San Diego Padres recalled RHP David Morgan from El Paso Chihuahuas. |
| 05/25/25 | San Diego Padres optioned RHP Alek Jacob to El Paso Chihuahuas. |
| 05/25/25 | San Diego Padres recalled LHP Omar Cruz from El Paso Chihuahuas. |
| 05/24/25 | San Diego Padres placed LF Jason Heyward on the 10-day injured list. Left oblique strain. |
| 05/24/25 | San Diego Padres recalled C Luis Campusano from El Paso Chihuahuas. |
| 05/20/25 | San Diego Padres sent 2B Mason McCoy on a rehab assignment to El Paso Chihuahuas. |
| 05/20/25 | San Diego Padres sent RHP Bryan Hoeing on a rehab assignment to San Antonio Missions. |
| 05/20/25 | San Diego Padres sent RHP Matt Waldron on a rehab assignment to San Antonio Missions. |
| 05/19/25 | San Diego Padres released LF Oscar Gonzalez. |
| 05/15/25 | San Diego Padres sent RHP Matt Waldron on a rehab assignment to ACL Padres. |
| 05/14/25 | San Diego Padres signed free agent RHP Jeferson Villabona to a minor league contract. |
| 05/14/25 | San Diego Padres sent RHP Yu Darvish on a rehab assignment to El Paso Chihuahuas. |
| 05/14/25 | San Diego Padres signed free agent RHP Jose Blanco to a minor league contract. |
| 05/10/25 | San Diego Padres sent RHP Bryan Hoeing on a rehab assignment to ACL Padres. |
| 05/10/25 | San Diego Padres sent RHP Bryan Hoeing on a rehab assignment to ACL Padres. |
| 05/09/25 | San Diego Padres activated 2B Jake Cronenworth from the 10-day injured list. |
| 05/09/25 | San Diego Padres traded 1B Connor Joe to Cincinnati Reds for RHP Andrew Moore and cash. |
| 05/09/25 | San Diego Padres traded 1B Connor Joe to Cincinnati Reds for RHP Andrew Moore and cash. |
| 05/08/25 | 1B Connor Joe roster status changed by San Diego Padres. |
| 05/08/25 | San Diego Padres optioned LF Oscar Gonzalez to El Paso Chihuahuas. |
| 05/07/25 | San Diego Padres activated RHP Sean Reynolds from the 15-day injured list. |
| 05/07/25 | San Diego Padres optioned RHP Ryan Bergert to El Paso Chihuahuas. |
| 05/06/25 | San Diego Padres sent 2B Jake Cronenworth on a rehab assignment to El Paso Chihuahuas. |
| 05/06/25 | San Diego Padres sent 2B Jake Cronenworth on a rehab assignment to El Paso Chihuahuas. |
| 05/06/25 | San Diego Padres activated CF Jackson Merrill from the 10-day injured list. |
| 05/06/25 | San Diego Padres placed CF Jackson Merrill on the 10-day injured list. Concussion. |
| 05/06/25 | San Diego Padres optioned C Luis Campusano to El Paso Chihuahuas. |
| 05/04/25 | San Diego Padres recalled RHP Stephen Kolek from El Paso Chihuahuas. |
| 05/04/25 | San Diego Padres optioned RHP David Morgan to El Paso Chihuahuas. |
| 05/03/25 | San Diego Padres sent 2B Jake Cronenworth on a rehab assignment to ACL Padres. |
| 05/03/25 | San Diego Padres sent CF Jackson Merrill on a rehab assignment to San Antonio Missions. |
| 05/03/25 | San Diego Padres sent 2B Jake Cronenworth on a rehab assignment to ACL Padres. |
| 05/03/25 | San Diego Padres recalled C Luis Campusano from El Paso Chihuahuas. |
| 05/03/25 | San Diego Padres sent 1B Yuli Gurriel outright to El Paso Chihuahuas. |
| 05/03/25 | San Diego Padres optioned 1B Connor Joe to El Paso Chihuahuas. |
| 05/02/25 | San Diego Padres activated CF Brandon Lockridge from the 10-day injured list. |
| 05/02/25 | San Diego Padres optioned LF Tirso Ornelas to El Paso Chihuahuas. |