Padres Roster & Staff
Transactions
| Date | Transaction |
| 10/09/25 | San Diego Padres signed free agent RHP Lan-Hong Su to a minor league contract. |
| 10/03/25 | San Diego Padres activated RF Ramón Laureano. |
| 10/03/25 | San Diego Padres activated LHP Kyle Hart. |
| 10/03/25 | San Diego Padres activated LHP Nestor Cortes. |
| 10/03/25 | San Diego Padres activated RHP Matt Waldron. |
| 10/03/25 | San Diego Padres activated 3B Will Wagner. |
| 10/03/25 | San Diego Padres activated RHP Sean Reynolds. |
| 10/03/25 | San Diego Padres activated LHP Yuki Matsui. |
| 10/03/25 | San Diego Padres activated LHP JP Sears. |
| 10/03/25 | San Diego Padres activated LF Tirso Ornelas. |
| 10/03/25 | San Diego Padres activated RHP Alek Jacob. |
| 10/03/25 | San Diego Padres activated LHP Omar Cruz. |
| 10/03/25 | San Diego Padres activated C Elias Díaz. |
| 10/03/25 | San Diego Padres activated RHP Ron Marinaccio. |
| 10/03/25 | San Diego Padres activated RHP Bryan Hoeing. |
| 10/02/25 | San Diego Padres signed free agent C Sebastian Maldonado to a minor league contract. |