Astros Roster & Staff
Transactions
| Date | Transaction |
| 07/31/21 | Houston Astros signed SS Hector G. Nieves. |
| 07/31/21 | Houston Astros selected the contract of CF Jake Meyers from Sugar Land Skeeters. |
| 07/31/21 | Houston Astros activated RHP Phil Maton. |
| 07/31/21 | Houston Astros designated RHP Nivaldo Rodriguez for assignment. |
| 07/31/21 | Houston Astros optioned RHP Brandon Bielak to Sugar Land Skeeters. |
| 07/31/21 | Houston Astros optioned RHP Bryan Abreu to Sugar Land Skeeters. |
| 07/30/21 | Cleveland Indians traded RHP Phil Maton and C Yainer Diaz to Houston Astros for RF Myles Straw. |
| 07/30/21 | Cleveland Indians traded RHP Phil Maton and C Yainer Diaz to Houston Astros for RF Myles Straw. |
| 07/30/21 | Houston Astros activated RHP Yimi Garcia. |
| 07/30/21 | Cleveland Indians traded RHP Phil Maton and C Yainer Diaz to Houston Astros for RF Myles Straw. |
| 07/30/21 | Baltimore Orioles claimed LHP Ryan Hartman off waivers from Houston Astros. |
| 07/28/21 | Houston Astros traded RF Bryan De La Cruz and RHP Austin Pruitt to Miami Marlins for RHP Yimi Garcia. |
| 07/28/21 | Houston Astros traded RF Bryan De La Cruz and RHP Austin Pruitt to Miami Marlins for RHP Yimi Garcia. |
| 07/28/21 | Houston Astros designated RHP Austin Pruitt for assignment. |
| 07/28/21 | Houston Astros traded RF Bryan De La Cruz and RHP Austin Pruitt to Miami Marlins for RHP Yimi Garcia. |
| 07/28/21 | Houston Astros activated RHP Rafael Montero. |
| 07/27/21 | Houston Astros activated RHP Kendall Graveman. |
| 07/27/21 | Houston Astros traded 3B Abraham Toro, RHP Joe Smith, and to Seattle Mariners for RHP Kendall Graveman and RHP Rafael Montero. |
| 07/27/21 | Houston Astros traded 3B Abraham Toro, RHP Joe Smith, and to Seattle Mariners for RHP Kendall Graveman and RHP Rafael Montero. |
| 07/27/21 | Houston Astros traded 3B Abraham Toro, RHP Joe Smith, and to Seattle Mariners for RHP Kendall Graveman and RHP Rafael Montero. |
| 07/27/21 | Houston Astros traded 3B Abraham Toro, RHP Joe Smith, and to Seattle Mariners for RHP Kendall Graveman and RHP Rafael Montero. |
| 07/27/21 | Houston Astros recalled 2B Robel Garcia from Sugar Land Skeeters. |
| 07/26/21 | Houston Astros sent 3B Alex Bregman on a rehab assignment to Sugar Land Skeeters. |
| 07/26/21 | Houston Astros activated SS Aledmys Diaz. |
| 07/26/21 | Houston Astros optioned 2B Robel Garcia to Sugar Land Skeeters. |
| 07/25/21 | Houston Astros activated LHP Brooks Raley. |
| 07/25/21 | Houston Astros designated LHP Ryan Hartman for assignment. |
| 07/25/21 | Houston Astros sent RHP Josh James on a rehab assignment to Sugar Land Skeeters. |
| 07/24/21 | Houston Astros optioned C Garrett Stubbs to Sugar Land Skeeters. |
| 07/23/21 | Houston Astros sent RHP Pedro Baez on a rehab assignment to Sugar Land Skeeters. |
| 07/22/21 | Houston Astros signed free agent RHP Jorge Geraldo to a minor league contract. |
| 07/21/21 | Houston Astros signed OF Tyler Whitaker. |
| 07/21/21 | Houston Astros signed RHP Adrian Chaidez. |
| 07/21/21 | Houston Astros signed RHP Bryant Salgado. |
| 07/21/21 | Houston Astros signed free agent OF Jaxon Hallmark to a minor league contract. |
| 07/21/21 | Houston Astros signed OF Joey Loperfido. |
| 07/20/21 | Houston Astros sent SS Aledmys Diaz on a rehab assignment to Corpus Christi Hooks. |
| 07/20/21 | Houston Astros sent LHP Brooks Raley on a rehab assignment to Sugar Land Skeeters. |
| 07/20/21 | Houston Astros signed free agent RHP Kasey Ford to a minor league contract. |
| 07/20/21 | Houston Astros signed free agent RHP Amilcar Chirinos to a minor league contract. |
| 07/20/21 | Houston Astros signed SS Chad Stevens. |
| 07/20/21 | Houston Astros signed free agent RHP Deylen Miley to a minor league contract. |
| 07/20/21 | Houston Astros signed 2B Kobe Kato. |
| 07/19/21 | Houston Astros placed RHP Andre Scrubb on the 10-day injured list. Right shoulder strain. |
| 07/19/21 | Houston Astros recalled C Garrett Stubbs from Sugar Land Skeeters. |
| 07/17/21 | Houston Astros signed RHP Rhett Kouba. |
| 07/17/21 | Houston Astros signed free agent RHP Jacob DeLabio to a minor league contract. |
| 07/17/21 | Houston Astros signed free agent RHP Marshall Hunt to a minor league contract. |
| 07/17/21 | Houston Astros signed RHP Nic Swanson. |
| 07/17/21 | Houston Astros signed free agent RHP Ray Gaither to a minor league contract. |
| 07/17/21 | Houston Astros signed free agent RHP Walker Brockhouse to a minor league contract. |
| 07/17/21 | Houston Astros signed free agent RHP Bryan Perez to a minor league contract. |
| 07/17/21 | Houston Astros signed 3B Justin Williams. |
| 07/17/21 | Houston Astros signed 2B Will Wagner. |
| 07/16/21 | Houston Astros activated SS Carlos Correa from the 10-day injured list. |
| 07/16/21 | Houston Astros signed RHP Aaron Brown. |
| 07/16/21 | Houston Astros signed RHP Chayce McDermott. |
| 07/16/21 | Houston Astros signed LHP Colton Gordon. |
| 07/16/21 | Houston Astros signed OF Quincy Hamilton. |
| 07/16/21 | Houston Astros signed OF Michael Sandle. |
| 07/16/21 | Houston Astros activated SS Carlos Correa from the 10-day injured list. |
| 07/16/21 | Houston Astros activated RHP Austin Pruitt. |
| 07/16/21 | Houston Astros activated SS Carlos Correa from the 10-day injured list. |
| 07/15/21 | Houston Astros optioned 1B Taylor Jones to Sugar Land Skeeters. |
| 07/15/21 | Houston Astros signed RHP Spencer Arrighetti. |
| 07/15/21 | Houston Astros sent RHP Pedro Baez on a rehab assignment to Fayetteville Woodpeckers. |
| 07/15/21 | Houston Astros signed free agent LHP Yoan Castillo to a minor league contract. |
| 07/14/21 | Houston Astros sent SS Aledmys Diaz on a rehab assignment to FCL Astros. |
| 07/12/21 | Houston Astros optioned RHP Ralph Garza Jr. to Sugar Land Skeeters. |
| 07/09/21 | Houston Astros placed SS Carlos Correa on the 10-day injured list. |
| 07/09/21 | Houston Astros recalled 1B Taylor Jones from Sugar Land Skeeters. |
| 07/08/21 | Houston Astros recalled RHP Ralph Garza Jr. from Sugar Land Skeeters. |
| 07/08/21 | Houston Astros placed LHP Brooks Raley on the 10-day injured list. |
| 07/07/21 | Houston Astros activated RHP Joe Smith. |
| 07/07/21 | Houston Astros optioned 1B Taylor Jones to Sugar Land Skeeters. |
| 07/06/21 | Houston Astros activated RHP Bryan Abreu. |
| 07/05/21 | Houston Astros optioned RHP Ralph Garza Jr. to Sugar Land Skeeters. |
| 07/05/21 | Houston Astros optioned RHP Peter Solomon to Sugar Land Skeeters. |
| 07/05/21 | Houston Astros activated C Martin Maldonado from the bereavement list. |
| 07/05/21 | Houston Astros optioned C Garrett Stubbs to Sugar Land Skeeters. |
| 07/05/21 | Houston Astros activated 1B Yordan Alvarez from the paternity list. |
| 07/05/21 | Houston Astros activated C Martin Maldonado from the bereavement list. |
| 07/05/21 | Houston Astros activated C Martín Maldonado from the bereavement list. |
| 07/04/21 | Houston Astros sent RHP Francis Martes outright to Sugar Land Skeeters. |
| 07/03/21 | Houston Astros activated RHP Enoli Paredes. |
| 07/03/21 | Houston Astros optioned RHP Enoli Paredes to Sugar Land Skeeters. |
| 07/02/21 | Houston Astros placed 1B Yordan Alvarez on the paternity list. |
| 07/02/21 | Houston Astros recalled 1B Taylor Jones from Sugar Land Skeeters. |
| 07/01/21 | Houston Astros optioned LHP Ryan Hartman to Sugar Land Skeeters. |
| 07/01/21 | Houston Astros sent RHP Josh James on a rehab assignment to Sugar Land Skeeters. |
| 07/01/21 | Houston Astros recalled RHP Peter Solomon from Sugar Land Skeeters. |
| 07/01/21 | Houston Astros sent RHP Joe Smith on a rehab assignment to Sugar Land Skeeters. |