The 2001 Mariners sent a franchise record by sending eight players to the midsummer classic, which was hosted at Safeco Field and managed by team skipper, Lou Piniella.
Mariners All-Stars
| Player | Position | Year(s) |
|---|---|---|
| Floyd Bannister | LHP | 1982 |
| Bruce Bochte | 1B | 1979 |
| Bret Boone | 2B | 2001 |
| Phil Bradley | OF | 1985 |
| Jay Buhner | OF | 1996 |
| Mike Cameron | OF | 2001 |
| Robinson Cano | 2B | 2014, '16, '17 (MVP) |
| Luis Castillo | RHP | 2023 |
| Joey Cora | 2B | 1997 |
| Nelson Cruz | DH | 2015, '17, '18 |
| Alvin Davis | 1B | 1984 |
| Edwin Diaz | RHP | 2018 |
| Ty France | 1B | 2022 |
| Freddy Garcia | RHP | 2001, '02 |
| Ken Griffey Jr. | OF | 1990, '91, '92 (MVP), '93, '94, '95, '96, '97, '98, '99 |
| Mitch Haniger | OF | 2018 |
| Shigetoshi Hasegawa | RHP | 2002 |
| Felix Hernandez | RHP | 2009, '11, '12, '13, '14, '15 |
| Rick Honeycutt | LHP | 1980 |
| Hisashi Iwakuma | RHP | 2013 |
| Randy Johnson | LHP | 1990, '93, '94, '95, '97 |
| Ruppert Jones | OF | 1977 |
| Yusei Kikuchi | LHP | 2021 |
| George Kirby | RHP | 2023 |
| Mark Langston | LHP | 1987 |
| Brandon League | RHP | 2011 |
| Jeffrey Leonard | OF | 1989 |
| Jose Lopez | 2B | 2006 |
| Edgar Martinez | 3B/DH | 1992, '95, '96, '97, 2000, '01, '03 |
| Tino Martinez | 1B | 1995 |
| Jamie Moyer | LHP | 2003 |
| Jeff Nelson | RHP | 2001 |
| John Olerud | 1B | 2001 |
| Tom Paciorek | OF | 1981 |
| Michael Pineda | RHP | 2011 |
| Lou Piniella | Coach | 2000, '01 |
| Jim Presley | 3B | 1986 |
| J.J. Putz | RHP | 2007 |
| Craig Reynolds | SS | 1978 |
| Harold Reynolds | 2B | 1987, '88 |
| Fernando Rodney | RHP | 2014 |
| Alex Rodriguez | SS | 1996, '97, '98, 2000 |
| Julio Rodríguez | OF | 2022, '23 |
| Kazuhiro Sasaki | RHP | 2001, '02 |
| Kyle Seager | 3B | 2014 |
| Jean Segura | SS | 2018 |
| Aaron Sele | RHP | 2000 |
| Ichiro Suzuki | OF | 2001, '02, '03, '04, '05, '06, '07 (MVP), '08, '09, '10 |
| Daniel Vogelbach | 1B/DH | 2019 |
| Dan Wilson | C | 1996 |
| Matt Young | LHP | 1983 |