Padres Roster & Staff
Transactions
| Date | Transaction |
| 04/30/25 | San Diego Padres signed free agent LHP Gensy Aquino to a minor league contract. |
| 04/29/25 | San Diego Padres activated 1B Luis Arraez from the 7-day injured list. |
| 04/29/25 | San Diego Padres designated 1B Yuli Gurriel for assignment. |
| 04/29/25 | San Diego Padres placed SS Mason McCoy on the 10-day injured list retroactive to April 28, 2025. Left finger sprain. |
| 04/29/25 | San Diego Padres activated LF Jason Heyward from the 10-day injured list. |
| 04/27/25 | San Diego Padres placed RHP Logan Gillaspie on the 15-day injured list. Left oblique strain. |
| 04/27/25 | San Diego Padres transferred RHP Bryan Hoeing from the 15-day injured list to the 60-day injured list. |
| 04/27/25 | San Diego Padres selected the contract of RHP David Morgan from San Antonio Missions. |
| 04/25/25 | San Diego Padres recalled RHP Ryan Bergert from El Paso Chihuahuas. |
| 04/25/25 | San Diego Padres optioned LHP Kyle Hart to El Paso Chihuahuas. |
| 04/22/25 | San Diego Padres signed free agent C Alberto Enriche to a minor league contract. |
| 04/22/25 | San Diego Padres signed free agent SS Eliander Primera to a minor league contract. |
| 04/22/25 | San Diego Padres signed free agent RHP Albert Perez to a minor league contract. |
| 04/22/25 | San Diego Padres signed free agent SS Abraham Bastidas to a minor league contract. |
| 04/22/25 | San Diego Padres sent RHP Sean Reynolds on a rehab assignment to El Paso Chihuahuas. |
| 04/21/25 | San Diego Padres signed free agent IF Ariel Dilone to a minor league contract. |
| 04/21/25 | San Diego Padres placed 1B Luis Arraez on the 7-day injured list. Concussion. |
| 04/21/25 | San Diego Padres signed free agent RHP Daniel Burciaga to a minor league contract. |
| 04/21/25 | San Diego Padres recalled SS Mason McCoy from El Paso Chihuahuas. |
| 04/19/25 | San Diego Padres placed LF Jason Heyward on the 10-day injured list retroactive to April 17, 2025. Left knee inflammation. |
| 04/19/25 | San Diego Padres recalled LF Tirso Ornelas from El Paso Chihuahuas. |
| 04/17/25 | Pittsburgh Pirates traded RF Bryce Johnson to San Diego Padres. |
| 04/16/25 | San Diego Padres signed free agent RHP Kelvin Marte to a minor league contract. |
| 04/16/25 | 2B Xander Bogaerts changed number to 2. |
| 04/16/25 | RHP Alek Jacob changed number to 37. |
| 04/16/25 | RF Fernando Tatis Jr. changed number to 23. |
| 04/16/25 | 3B Manny Machado changed number to 13. |
| 04/16/25 | RHP Nick Pivetta changed number to 27. |
| 04/16/25 | RF Jason Heyward changed number to 22. |
| 04/16/25 | 1B Connor Joe changed number to 24. |
| 04/16/25 | C Elias Díaz changed number to 17. |
| 04/16/25 | RF Oscar Gonzalez changed number to 39. |
| 04/16/25 | RHP Logan Gillaspie changed number to 71. |
| 04/16/25 | OF Gavin Sheets changed number to 30. |
| 04/16/25 | 3B Tyler Wade changed number to 14. |
| 04/16/25 | LHP Kyle Hart changed number to 68. |
| 04/16/25 | C Martín Maldonado changed number to 15. |
| 04/16/25 | 1B Yuli Gurriel changed number to 10. |
| 04/16/25 | 2B Jose Iglesias changed number to 7. |
| 04/16/25 | LHP Adrian Morejon changed number to 50. |
| 04/16/25 | San Diego Padres activated CF Tyler Wade. |
| 04/16/25 | RHP Dylan Cease changed number to 84. |
| 04/16/25 | LHP Wandy Peralta changed number to 58. |
| 04/16/25 | RHP Jeremiah Estrada changed number to 56. |
| 04/16/25 | RHP Jason Adam changed number to 40. |
| 04/16/25 | 1B Luis Arraez changed number to 4. |
| 04/16/25 | LHP Yuki Matsui changed number to 1. |
| 04/16/25 | RHP Randy Vásquez changed number to 98. |
| 04/16/25 | RHP Michael King changed number to 34. |
| 04/16/25 | RHP Robert Suarez changed number to 75. |
| 04/16/25 | San Diego Padres traded C Brett Sullivan to Pittsburgh Pirates. |
| 04/15/25 | C Martín Maldonado changed number to 42. |
| 04/15/25 | LHP Kyle Hart changed number to 42. |
| 04/15/25 | RHP Dylan Cease changed number to 42. |
| 04/15/25 | RF Oscar Gonzalez changed number to 42. |
| 04/15/25 | RHP Logan Gillaspie changed number to 42. |
| 04/15/25 | C Elias Díaz changed number to 42. |
| 04/15/25 | 1B Connor Joe changed number to 42. |
| 04/15/25 | RHP Nick Pivetta changed number to 42. |
| 04/15/25 | RF Jason Heyward changed number to 42. |
| 04/15/25 | 2B Jose Iglesias changed number to 42. |
| 04/15/25 | 1B Yuli Gurriel changed number to 42. |
| 04/15/25 | 3B Tyler Wade changed number to 42. |
| 04/15/25 | 2B Xander Bogaerts changed number to 42. |
| 04/15/25 | OF Gavin Sheets changed number to 42. |
| 04/15/25 | 1B Luis Arraez changed number to 42. |
| 04/15/25 | RHP Jason Adam changed number to 42. |
| 04/15/25 | LHP Yuki Matsui changed number to 42. |
| 04/15/25 | LHP Wandy Peralta changed number to 42. |
| 04/15/25 | RHP Randy Vásquez changed number to 42. |
| 04/15/25 | RHP Alek Jacob changed number to 42. |
| 04/15/25 | RHP Jeremiah Estrada changed number to 42. |
| 04/15/25 | LHP Adrian Morejon changed number to 42. |
| 04/15/25 | RHP Robert Suarez changed number to 42. |
| 04/15/25 | 3B Manny Machado changed number to 42. |
| 04/15/25 | RHP Michael King changed number to 42. |
| 04/15/25 | RF Fernando Tatis Jr. changed number to 42. |
| 04/14/25 | San Diego Padres placed RF Brandon Lockridge on the 10-day injured list. Left hamstring strain. |
| 04/14/25 | San Diego Padres recalled 1B Connor Joe from El Paso Chihuahuas. |
| 04/11/25 | San Diego Padres transferred RHP Matt Waldron from the 15-day injured list to the 60-day injured list. Left oblique muscle strain. |
| 04/11/25 | San Diego Padres placed 1B Jake Cronenworth on the 10-day injured list retroactive to April 9, 2025. Non-displaced right rib fracture. |
| 04/11/25 | San Diego Padres selected the contract of 3B Tyler Wade from El Paso Chihuahuas. |
| 04/10/25 | San Diego Padres traded LHP Tom Cosgrove to Chicago Cubs for cash. |
| 04/08/25 | San Diego Padres placed CF Jackson Merrill on the 10-day injured list retroactive to April 7, 2025. Right hamstring strain. |
| 04/08/25 | San Diego Padres recalled RF Oscar Gonzalez from El Paso Chihuahuas. |
| 04/06/25 | San Diego Padres designated LHP Tom Cosgrove for assignment. |
| 04/06/25 | San Diego Padres optioned LHP Omar Cruz to El Paso Chihuahuas. |
| 04/06/25 | San Diego Padres selected the contract of RHP Logan Gillaspie from El Paso Chihuahuas. |
| 04/03/25 | San Diego Padres transferred RHP Jhony Brito from the 15-day injured list to the 60-day injured list. Right forearm strain. |
| 04/03/25 | San Diego Padres optioned RF Oscar Gonzalez to El Paso Chihuahuas. |
| 04/03/25 | San Diego Padres sent 3B Eguy Rosario outright to El Paso Chihuahuas. |
| 04/03/25 | San Diego Padres selected the contract of RF Oscar Gonzalez from El Paso Chihuahuas. |
| 04/02/25 | San Diego Padres sent 3B Tyler Wade outright to El Paso Chihuahuas. |