Reds Roster & Staff
Transactions
| Date | Transaction |
| 04/28/16 | Cincinnati Reds sent RHP Anthony DeSclafani on a rehab assignment to Dayton Dragons. |
| 04/28/16 | Cincinnati Reds optioned RHP Layne Somsen to Louisville Bats. |
| 04/28/16 | Cincinnati Reds activated RF Jay Bruce from the paternity list. |
| 04/26/16 | Cincinnati Reds sent RHP Homer Bailey on a rehab assignment to Pensacola Blue Wahoos. |
| 04/25/16 | Cincinnati Reds transferred RHP Michael Lorenzen from the 15-day disabled list to the 60-day disabled list. Right elbow sprain |
| 04/25/16 | Cincinnati Reds signed free agent RF Kyle Parker to a minor league contract. |
| 04/25/16 | Cincinnati Reds selected the contract of Layne Somsen from Louisville Bats. |
| 04/25/16 | Cincinnati Reds placed RF Jay Bruce on the paternity list. |
| 04/24/16 | Cincinnati Reds sent RHP Tim Melville outright to Louisville Bats. |
| 04/23/16 | Cincinnati Reds sent RHP Anthony DeSclafani on a rehab assignment to Pensacola Blue Wahoos. |
| 04/22/16 | Cincinnati Reds sent Keyvius Sampson outright to Louisville Bats. |
| 04/22/16 | Cincinnati Reds designated RHP Tim Melville for assignment. |
| 04/22/16 | Cincinnati Reds selected the contract of RHP JC Ramirez from Louisville Bats. |
| 04/21/16 | Cincinnati Reds sent RHP Homer Bailey on a rehab assignment to Louisville Bats. |
| 04/20/16 | Cincinnati Reds selected the contract of Drew Hayes from Louisville Bats. |
| 04/20/16 | Cincinnati Reds designated RHP Keyvius Sampson for assignment. |
| 04/20/16 | Cincinnati Reds optioned RHP Robert Stephenson to Louisville Bats. |
| 04/19/16 | Cincinnati Reds optioned RHP Jumbo Diaz to Louisville Bats. |
| 04/19/16 | Cincinnati Reds recalled Robert Stephenson from Louisville Bats. |
| 04/17/16 | Cincinnati Reds activated RHP Jon Moscot from the 15-day disabled list. |
| 04/17/16 | Cincinnati Reds optioned RHP Keyvius Sampson to Louisville Bats. |
| 04/16/16 | Cincinnati Reds sent LHP John Lamb on a rehab assignment to Louisville Bats. |
| 04/12/16 | Cincinnati Reds sent RHP Jon Moscot on a rehab assignment to Louisville Bats. |
| 04/10/16 | Cincinnati Reds designated 1B Brandon Allen for assignment. |
| 04/10/16 | Cincinnati Reds selected the contract of RHP Tim Melville from Louisville Bats. |
| 04/10/16 | Cincinnati Reds sent 1B Brandon Allen outright to Louisville Bats. |
| 04/08/16 | Cincinnati Reds optioned RHP Robert Stephenson to Louisville Bats. |
| 04/08/16 | Cincinnati Reds selected the contract of 1B Brandon Allen from Louisville Bats. |
| 04/07/16 | Cincinnati Reds sent RHP Jon Moscot on a rehab assignment to Daytona Tortugas. |
| 04/06/16 | Cincinnati Reds signed free agent RHP Elias Puche to a minor league contract. |
| 04/06/16 | Cincinnati Reds signed free agent LHP Greg Williams to a minor league contract. |
| 04/06/16 | Cincinnati Reds signed free agent 1B Justin Chigbogu to a minor league contract. |
| 04/06/16 | Cincinnati Reds signed free agent LHP Jaccen Centeno to a minor league contract. |
| 04/05/16 | CF Jake Cave returned to New York Yankees from Cincinnati Reds. |
| 04/04/16 | Cincinnati Reds placed RHP Homer Bailey on the 15-day disabled list retroactive to March 25, 2016. Recovering May 2015 Tommy John surgery |
| 04/04/16 | Cincinnati Reds recalled Robert Stephenson from Louisville Bats. |
| 04/03/16 | Cincinnati Reds selected the contract of C Jordan Pacheco from Louisville Bats. |
| 04/03/16 | Cincinnati Reds designated Jake Cave for assignment. |
| 04/03/16 | Cincinnati Reds placed RHP Anthony DeSclafani on the 15-day disabled list retroactive to March 25, 2016. Mild oblique strain |
| 04/03/16 | Cincinnati Reds placed LHP John Lamb on the 15-day disabled list retroactive to March 25, 2016. Recovering from December 2015 back surgery |
| 04/03/16 | Cincinnati Reds optioned C Ramon Cabrera to Louisville Bats. |
| 04/03/16 | Cincinnati Reds optioned 2B Jose Peraza to Louisville Bats. |
| 04/03/16 | Cincinnati Reds recalled CF Tyler Holt from Louisville Bats. |
| 04/03/16 | Cincinnati Reds placed RHP Michael Lorenzen on the 15-day disabled list retroactive to March 25, 2016. Right elbow sprain |
| 04/03/16 | Cincinnati Reds placed RHP Jon Moscot on the 15-day disabled list retroactive to March 25, 2016. Right intercostal strain |
| 04/03/16 | Cincinnati Reds placed CF Yorman Rodriguez on the 15-day disabled list retroactive to March 27, 2016. Left hamstring strain |
| 04/03/16 | Cincinnati Reds placed C Kyle Skipworth on the 15-day disabled list retroactive to March 31, 2016. Recovering from December 2015 left ankle surgery |
| 04/03/16 | Juan Duran roster status changed by Cincinnati Reds. |
| 04/02/16 | Cincinnati Reds signed free agent RHP Steve Delabar to a minor league contract. |
| 04/01/16 | Cincinnati Reds claimed RHP Dan Straily off waivers from San Diego Padres. |