April 4, 2005 – Third baseman Joe Randa hits a walk-off home run on Opening Day to defeat the Mets.
April 3, 2006 - George W. Bush becomes the first sitting president ever to throw out an Opening Day first pitch in Cincinnati and only the second sitting president to participate in the pregame ceremony.
Sept. 26, 2007 - Brandon Phillips hits his 30th home run to become the second second baseman in Major League history to produce 30 HR and 30 SB in the same year.
Sept. 28, 2010 - Jay Bruce’s home run on the first pitch from Tim Byrdak in the bottom of the ninth inning gives the Reds a 3-2 win vs. the Astros, clinching the NL Central for the Reds for the first time since 1995.
March 31, 2011 – Catcher Ramon Hernandez belts a walk-off three-run homer to give the Reds a thrilling comeback win on Opening Day.
July 2, 2013 – Homer Bailey throws the first no-hitter in Great American Ball Park history, and his second in less than 12 months; the Cubs’ Jake Arrieta would throw the ballpark’s only other no-no on April 21, 2016.
July 13, 2015 – Todd Frazier outduels the Dodgers’ Joc Pederson in the final round to win the 2015 MLB Home Run Derby as part of All-Star Week at Great American Ball Park.
June 6, 2017 – Scooter Gennett becomes the first player in franchise history to hit four home runs in a game in a 13-1 victory over the Cardinals.
Sept. 4, 2019 – Michael Lorenzen becomes the first player since Babe Ruth to earn the victory, hit a home run and play outfield in the same game.
2021 - Joey Votto records his 300th home run, 1,000th RBI and 2,000th hit of his career in the three different games during the same season.